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17 Cards in this Set

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  • Back
Ischemic Stroke
Decreased blood flow to area in brain
Majority of strokes are this type
Cerebral Thrombosis
Clot forms in brain, most common type of ischemic stroke
Cerebral Embolism
Clot forms elsewhere and travels to the brain
*Can be caused by atrial fibrilation-->blood pools in atrial and clots can form
Hemorrhagic Stroke
Bursting of an artery
Hard to treat
*Risk Factors: High BP, Warfarin
Cerebral Hemorrhage
Bursting of artery inside the brain
Subarachnoid Hemorrhage
Burst artery is outside brain
Middle Cerebral Artery
Provides blood flow to large cortical and subcortical territories
2/3 of ischemic strokes occur in the middle cerebral artery and its branches
Transient Ischemic Attack (TIA)
Brief episode of focal loss of brain function attributable to ischemia
-Generally lasts less than 24 hours (mini-stroke)
-No long term effects
Uses of stroke scales
Evaluate the outcome of therapeutic agents in clinical trials
Detect a change in a patients condition during monitoring at the stroke unit
Assist in the planning for rehab
tPA
Tissue Plasminogen Activator
-Only FDA approved drug for tx of stroke
-Effective only for ischemic stroke -->makes hemorrhagic worse
-Must be given within 3 hours of stoke onset
Heparin
Prevents platelet aggregation
-Not FDA approved
-No evidence that it works
Excitotoxicity
Overstimulation of the glutamate receptors-->leading to neuronal death
Anti-excitoxicity FDA approved drugs
Memantine
Amantadine
Rilusole
Glutatmate Antagonists
Not great drugs for tx
Only slows the progression by a small amount
-Many side effects
-Must get drug to people very quickly
Potential Treatments for Stroke
Glutamate Receptor Antagonists
Neurotrophic Factors
Stem Cells
Growth Factors
Proteins that can regulate survivial and differentiation of cells
-Prevent apoptosis-->keep cells alive
Nuerotrophic Factors
Specifically act on neurons to keep them alive