Stimulatns

Front 1

CNS effects

Back 1

1)delay of fatigue induced decline in performance
2)amphetamine psychosis
3)appetite suppression
4)tolerance, dependence, rebound

Front 2

Peripheral effects

Back 2

1)autonomic - HTN, tachy, arrhythmias, mydriasis
2)malnutrition

Front 3

Toxicity

Back 3

1)sympathomimetic
2)CNS-hostility, aggression, psychotic reactions, TACTILE HALLUCINATIONS
3)dopaminergic and serotenergic pathway degeneration

Front 4

MOA

Back 4

ACUTE
-NE and DA enhanced release and reuptake inhibition
CHRONIC
-DA levels decreased in reward centers
OTHER
-alpha receptor direct stimulation

Front 5

Cocaine pharmacologic effects

Back 5

1)increased CONFIDENCE
2)powerful REINFORCER
3)psychotic reactions

Front 6

Cocaine peripheral effects

Back 6

1)Autonomic-HTN, tachy, arrhythmias, mydriasis
2)lung damage/pulmonary edema
3)teratogenic

Front 7

Cocaine MOA

Back 7

1)Block synaptic reuptake of dopamine -> increase dopamine producing euphoria/reinforcement
2)repetitive usage sees the presynaptic neuron unable to replenish lost dopamine

Front 8

Cocaine drug dependence treatment

Back 8

1)BUPROPION
2)BUPRENORPHINE
3)bromocriptine

Front 9

Cocaine overdose treatment

Back 9

1)no antidote
2)control body temperature
3)Seizure and cardiac arrhythmia protection

Front 10

Hallucinogens
INDOLES

Back 10

1)LSD
2)Psilocybin and psilocin
3)Bufotenin
4)Ibogaine

Front 11

Hallucinations
-PHENYLETHYLAMINES

Back 11

1)Mescaline
2)MDMA

Front 12

HCN sympathomimetic effects

Back 12

1)mydriasis
2)incrase BP, HR, body temp
3)piloerection
4)tremors

Front 13

HCN subjective psychic changes

Back 13

1)anxiety
2)euphoria
3)emotional lability

Front 14

HCN (psychogenic) effects after 1-3 hours

Back 14

1)Sensory distortions - increased awareness, SNESTHESIAS
2)Depersonalization
3)Paranoia
4)Panic reactions

Front 15

HCN signs of acute poisoning

Back 15

1)fear
2)panic
3)paranoiaq

Front 16

HCN acute poisoning treatment

Back 16

1)calming and reassuring
2)Anxiolytics
3)Antipsychotics

Front 17

Found in hallucinogen mushrooms

Back 17

psilocin and psilocybin

Front 18

Found in some mushrooms and in the skin of some amphibians

Back 18

Bufotenin

Front 19

Found in buttons of the peyote cactus

Back 19

Mescaline

Front 20

Powerful hallucinogen that has recently been reported to suppress the craving for heroin, cocaine and other drugs in addicted indivusals

Back 20

Ibogaine

Front 21

Tolerance and physical dependence

Back 21

1)don't cause physical dependence
2)tolerance develops to psychogenic effects rapidly 2-3 doses

Front 22

Usage of LSD has been shown to be associated with long-term changes in processing of visual information

Back 22

hallucinogen persisting perception disorder (HPPD)

Front 23

HCN MOA

Back 23

1)5HT2 presynaptic receptor agonists ->decrease rate of firing of 5-HT ->alterations in functioning of the reticular senosry filtering system

Front 24

Phencyclidine (PCP; Angel Dust, Ketamine) pharmacological effects

Back 24

1)amphetamine like stimulant effects
2)RAGE reactions, PSYCHOTIC REACTIONS
3)HYPERREFLEXIA
4)ANALGESIC activity-no pain

Front 25

Phencyclidine MOA

Back 25

blockade of NMDA receptors

Front 26

Phencyclidine symptoms of acute poisoning

Back 26

1)HYPERREFLEXIA
2)INCREASED MUSCLE TONE
3)HYPERTENSION
4)VERTICAL NYSTAGMUS
5)cardiac, respiratory depression, coma

Front 27

Phencyclidine treatment of acute poisoning

Back 27

1)decrease sensory stimulation
2)antipsychotics
3)anticonvulsants
4)antihypertensives
5)support respiration
6)acidify urine

Front 28

Symptoms of phencyclidine withdrawal

Back 28

MILD and DO NOT REQUIRE TREATMENT
-craving
-fear, anxiety, restlessness