Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/28

Click to flip

28 Cards in this Set

  • Front
  • Back
CNS effects
1)delay of fatigue induced decline in performance
2)amphetamine psychosis
3)appetite suppression
4)tolerance, dependence, rebound
Peripheral effects
1)autonomic - HTN, tachy, arrhythmias, mydriasis
2)malnutrition
Toxicity
1)sympathomimetic
2)CNS-hostility, aggression, psychotic reactions, TACTILE HALLUCINATIONS
3)dopaminergic and serotenergic pathway degeneration
MOA
ACUTE
-NE and DA enhanced release and reuptake inhibition
CHRONIC
-DA levels decreased in reward centers
OTHER
-alpha receptor direct stimulation
Cocaine pharmacologic effects
1)increased CONFIDENCE
2)powerful REINFORCER
3)psychotic reactions
Cocaine peripheral effects
1)Autonomic-HTN, tachy, arrhythmias, mydriasis
2)lung damage/pulmonary edema
3)teratogenic
Cocaine MOA
1)Block synaptic reuptake of dopamine -> increase dopamine producing euphoria/reinforcement
2)repetitive usage sees the presynaptic neuron unable to replenish lost dopamine
Cocaine drug dependence treatment
1)BUPROPION
2)BUPRENORPHINE
3)bromocriptine
Cocaine overdose treatment
1)no antidote
2)control body temperature
3)Seizure and cardiac arrhythmia protection
Hallucinogens
INDOLES
1)LSD
2)Psilocybin and psilocin
3)Bufotenin
4)Ibogaine
Hallucinations
-PHENYLETHYLAMINES
1)Mescaline
2)MDMA
HCN sympathomimetic effects
1)mydriasis
2)incrase BP, HR, body temp
3)piloerection
4)tremors
HCN subjective psychic changes
1)anxiety
2)euphoria
3)emotional lability
HCN (psychogenic) effects after 1-3 hours
1)Sensory distortions - increased awareness, SNESTHESIAS
2)Depersonalization
3)Paranoia
4)Panic reactions
HCN signs of acute poisoning
1)fear
2)panic
3)paranoiaq
HCN acute poisoning treatment
1)calming and reassuring
2)Anxiolytics
3)Antipsychotics
Found in hallucinogen mushrooms
psilocin and psilocybin
Found in some mushrooms and in the skin of some amphibians
Bufotenin
Found in buttons of the peyote cactus
Mescaline
Powerful hallucinogen that has recently been reported to suppress the craving for heroin, cocaine and other drugs in addicted indivusals
Ibogaine
Tolerance and physical dependence
1)don't cause physical dependence
2)tolerance develops to psychogenic effects rapidly 2-3 doses
Usage of LSD has been shown to be associated with long-term changes in processing of visual information
hallucinogen persisting perception disorder (HPPD)
HCN MOA
1)5HT2 presynaptic receptor agonists ->decrease rate of firing of 5-HT ->alterations in functioning of the reticular senosry filtering system
Phencyclidine (PCP; Angel Dust, Ketamine) pharmacological effects
1)amphetamine like stimulant effects
2)RAGE reactions, PSYCHOTIC REACTIONS
3)HYPERREFLEXIA
4)ANALGESIC activity-no pain
Phencyclidine MOA
blockade of NMDA receptors
Phencyclidine symptoms of acute poisoning
1)HYPERREFLEXIA
2)INCREASED MUSCLE TONE
3)HYPERTENSION
4)VERTICAL NYSTAGMUS
5)cardiac, respiratory depression, coma
Phencyclidine treatment of acute poisoning
1)decrease sensory stimulation
2)antipsychotics
3)anticonvulsants
4)antihypertensives
5)support respiration
6)acidify urine
Symptoms of phencyclidine withdrawal
MILD and DO NOT REQUIRE TREATMENT
-craving
-fear, anxiety, restlessness