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24 Cards in this Set
- Front
- Back
topical Ampho B
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Nystatin
MOA: bind ergosterol |
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AmphoB MOA
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binds ergosterol----> causes pore
S/E- arrythmias, fever/ chills, anemia, phlebitis, nephrotoxic |
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Nystain uses
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-oral thrush
-diaper rash - |
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Azoles MOA
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(-) synthesis of ergosterol
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Fluocytosine MOA
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(-) RNA/ DNA biosynthesis
-converts to 5'-fluorouracil |
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Capsofungin MOA
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(-) synthesis of beta-glucan----> no cell wall synthesis
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Micafungin MOA
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Terbinafine MOA
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(-) squalene epoxidase
Tx; dermatophytoses |
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Griseofulvin MOA
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(-) microtubule formation
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(-) squalene eopxidase(anti-fungal)
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Terbinafine
Tx: dermatophytoses S/E- high LFT, visual disturbances |
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(-) microtubule formation in fungal cells
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Griseofulvin
***deposits in keratin-tissues**** S/E- teratogenic, carcinogenic, increase warfarin metabolism |
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testosterone inhibition S/E w/ fungal Tx
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Azoles--> (-) ergosterol synthesis
also causes liver dysfxn |
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DOC thrush
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Nystatin---> binds ergosterol
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DOC prevention of vertical HIV
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Zidovudine
MOA- NRTI (nucleoside RT inhibitor) |
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Zidovudine
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NRTI
DOC prenatal HIV S/E- BM supression, lactic acidosis, peripheral neuropathy, ANEMIA |
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NRTIs
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-Zidovudine
-Tenofovir -Abacavir -Lamivudine -Didanosine -Stavidune |
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Tenofovir
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NRTI----> does not require activation
S/E- BM supression, peripheral neuropathy, lactic acidosis |
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NRTI which does not require activation
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Tenofovir
NRTIs requiring activation: Zidovudine, Abacavir, Didanosine, Stavudine, Lamivudine |
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Lamivudine
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NRTI- requires conversion
S/E- peripheral neuropathy, lactic acidosis, BM supression |
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Stavudine
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HIV fusion inhibitor
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Enfuvirtide (only one)
blocks gp41 |
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Raltegravir
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(-) HIV integrase
S/E- hypercholesterolemia |
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HIV integrase inhibitor
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Raltegravie
S/E Hypercholesterolemia |
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protease inhibitor names
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end in "-NAVIR"
LopiNAVIR AtazaNAVIR DaruNAVIR FosampreNAVIR (and others) |