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295 Cards in this Set
- Front
- Back
Hyperplasia without atypia - should have high or low threshold for hysterectomy?
how to tx? |
high - they respond v. well to cyclic progestins! - be sure to repeat bx in 3-6 months
|
|
Pruritis, inflammation, and elevation of vaginal d/c pH - dx?
|
trichomonas - NOT BACTERIAL VAGINOSIS/GARDNERELLA!!!
no discomfort with BV |
|
primary amenorrhea, bilar ing masses, breast devo but no pubic hair or axillary hair in a female - dx?
|
androgen insensitivity syndrome - they need gonadectomy so they don't get cancer and estrogen aroudn teh time of puberty
|
|
Two things that stimulate prolactin
|
TRH and serotonin
|
|
Pregnancy luteoma - what is it?
|
HCG makes luteal stromal cells replace the normal ovarian parenchyma so they get ovarian masses. More common in AAs. Sx similar to PCOS (virilization, hirsutism).
|
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what hormone develops breasts?
|
estrogen
|
|
primary amenorrhea in a pt with no sex characteristics - first test to order?
|
fsh to tell if it is central (hypothal/pit) or gonadal
if high - periph lesion so get a karyotype if low - central lesion so get gnrh stim test |
|
work-up of low grade squamous intraepith lesions ( which is mild dysplasia or CIN 1)
|
adolescents - repeat pap in 12 months (takes a while to develop anyway)
premenopausal - colposcopy and then biopsy (because they are a hgih risk group) postmenopausal - hpv testing and if positive, colposcopy |
|
Tx of vaginal squamous cell ca
|
steage 1-2 - localized and <2cm - remove surgically
stage 1-2 - localized and <2cm - radiation over 4cm or extensive - combination chemo |
|
ovarian masses that do not produce estrogen or androgens
|
dysgerminoma, mature teratoma, serous cystadenoma
NOT GRANULOSA CELL TUMORS! |
|
role of alcohol and risk of osteoporosis
|
a very serious one - and it is dose dependent
|
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pt has suspected ___ towards end of pregnancy, don't do vaginal exam!
|
placenta previa
|
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Cause of early decelerations
|
fetal head compression leading to a vagal response
|
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cause of variable decelerations during labor
|
umbilical cord compression
|
|
parameters of biophysical profile
|
nonstress test (reactive)
fetal tone (flexion or ext of an extrem) fetal movements (at least 2 in 30min) fetal breathing (at elast 20 seconds in 30 minutes) amniotic fluid volume (single pocket >2cm in vertical axis) |
|
when to deliver based on biophysical profile
|
decreased amniotic fluid - consider it
<=6 and >37wks - if <37 repeat BPP in 24 hours and deliver if not improved <=4 and >26 wks - deliver |
|
Kallmann's syndrome - what is it? associated with...?
|
congen absence of GnRH secretion
assoc with anosmia |
|
mullerian duct leads to devo of...
|
proximal vagina and uterus
so blind pouch without it |
|
pt has female phenotype but then virilization at puberty - dx?
|
5-alpha-reductase deficiency - XY genotype
|
|
pink smooth teardrop lesions on vulva that go away with trichloroacetic acid or podophyllin - dx?
|
HPV warts (condyloma acuminata)
|
|
what do clue cells look like in bacterialvaginosis (gardnerella)
|
epithelial cells coated with bacteria
|
|
metro safe to use during preg?
|
yes
|
|
azithromycin or erthromycin - which safe to use in pregnancy?
AE of erythro? |
azith
eryth can cause acute cholestatic hepatitis |
|
post-term pregnancy - definition and what to watch for?
|
>42 weeks
watch for oligohydramnios |
|
name of plan b? how long out can you give it?
|
levonorgestrel
120 hours |
|
main organ issue in pts with turner's syndrome
|
ovarian dysgenesis
|
|
Tx of candida vaginitis
|
fluconazole
|
|
Definition of mild vs. severe preeclampsia
|
Mild - proteinuria >0.3g/24h
BP>140/90 Severe - HTN>160/110; >5g/24h, or organ dysfunc |
|
Chronic HTN in pregnancy - what is it?
|
HTN not due to pregnancy, so before 20th week or present before preggo - if get proteinuria with it, it's called chronic HTN with superimposed preeclampsia
|
|
Tamoxifen - agonist/antag where?
|
agonist - endometrium, osteoclasts (so less osteopor risk)
antag - breast no known effect with ovaries |
|
when is ionizing radiation most harmful to a fetus?
|
8-15 weeks
|
|
hormone malfunc in anorexics
|
low gnrh and lh, so low estrogen states
|
|
who is most at risk for fetal limb defect when getting chorionic villus sampling
|
babies <9-10weeks gestation - so you typically do it btwn 10-12 weeks
|
|
how to assess infertility due to aging -
|
early follicular phase FSH level, clomiphene challenge test or inhibin B level
(inhibin inhibits FSH) |
|
Chancroid - what is the bug, what does the lesion look/feel like
|
ulcer that is deep and purulent and painful lymphadenopathy
caused by haemophilis ducreyi |
|
adenopathy with granuloma inguinale?
pain? |
no - painless too
|
|
First step if you suspect fetal compromise?
Fetal demise? |
compromise - NST
demise - ultrasound |
|
pt has lichen sclerosis - next step?
|
punch bx to make sure there is no SCC
|
|
When to give GBS ppx
|
if test positive 2-3 weeks before delivery, had baby with gbs in past, or tested positive in the past
|
|
role of human placental lactogen - other name for it?
|
maternal lipolysis and insulin resistance so the baby gets more glucose
chorionic somatomammotropin |
|
what causes variable decels
|
fetal cord compression
|
|
dysmennorhia, heavy menses, large uterus - dx?
|
fibroid uterus
|
|
fsh and lh - low or high with klinefelter's?
|
high
|
|
Primary dysmenorrhea - signs/sx, cause, and tx?
|
s/s - lower abd pain rad to thighs and back during menstruation
cause - increase prostaglandins during breakdown of endometrium tx - nsaids |
|
fixed retroverted uterus should make you think of...
|
endometriosus
|
|
is endometriosus a risk factor for infertility?
|
yes
|
|
Baby sequalae of maternal diabetes
|
polycythemia (due to increase BMR and resultant epo)
macrosomia, hypocalcemia (PTH suppression), hypogly, resp diff, cardiomyopathy, CHF |
|
why do we worry about asymp bacteruria in preggo pt?
|
can get pyelonephritis --> septicemia, preterm labor and low birth weight babies
|
|
normal 1 hour GTT (50g)
|
<140
|
|
in general, baby is going to die, mother is preterm, do a c section or vaginal deliv?
|
vaginal
|
|
corpus luteum secretes...
|
progesterone, and it is maintained by hcg
|
|
role of progesterone during preg
|
inhibit uterine contractions
|
|
hormone that induces prolactin during pregnancy
|
estrogen - actually - wait - this might be wrong...
|
|
urinary urgency/freq and chronic pelvic pain - also dysparunia - negative UA - consider which dx?
|
chronic interstitial cystitis
|
|
signs of ovulation -
|
breast tenderness, midcycle pelvic pain (Mittelschmertz)
|
|
serum inhibin b levels used for...
|
determining ovulatory reserve
|
|
Treatment of infertility in pt with PCOS
|
metformin and clomiphene
|
|
DES causes...
|
clear cell adenocarcinoma of vagina and cervix in the children
|
|
steroids to mature lungs - no benefit after...
|
34 weeks
|
|
can ERT help with urine incontinence?
|
yes
|
|
when to do uterine artery embolization
|
PP hemorrhage but not excessive bleeding and pt wants to maintain fertility (contrast to hysterectomy)
|
|
RFs for uterine atony
|
distention of uterus intrapartum or prolonged labor
|
|
oxybutynin - used for which incontinence?
|
urge - anticholinergic
|
|
urethopexy - used for what incontinence?
|
stress - supports urethra
|
|
w/u of infertility
|
1.) check male
2.) assess for ovulation 3.) hysterosalpingogram |
|
Pseudocyesis
|
conversion disorder - mimics pregnancy in a pt who really wants to become pregnant
|
|
when to screen for gestational DM
|
hx of DM - first prenatal visit
all others - btwn 24 and 28 weeks |
|
initial screening test for gestational DM
|
1 hour 50g glucose tolerance (if >140 - do 3 hours GTT or 2 hour 75g)
|
|
criteria for 3 hour glucose tolerance test
|
2 or more are elevated:
fasting >95 1 hour >180 2 hour > 155 2 hour > 140 |
|
US - useful to dx placenta previa or abruption?
|
previa
|
|
septic abortion - gentle or vigorous curettage?
|
gentle - don't want to perforate it.
|
|
next steps of action when BPP is...
|
<4 - deliver
4 without oligohydramnios and fetal lungs are not mature - steroids and repeat BPP in 24h 6 without oligohydramnios - contraction stress test oligohydramnios present - deliver |
|
woman comes in with PROM at <37 weeks - what to do?
what is <32 weeks |
GBS ppx and let her deliver
if before 32 - give tocolytic and let lungs mature |
|
most preventable cause of fetal growth restriction
|
smoking
|
|
Tons of N/V in a pt at about 10 weeks gestation - consider what dx?
|
gestational trophoblastic dz
NB - will see elevated liver enzymes and amylase and lipase with hyperemesis gravidarum |
|
spinal anesthesia - can slow labor if given in the ____ stage
|
latent (before cervix is 3-4cm dilated)
|
|
If Rh antibody titers are ___, need Rhogam
|
<1:6 (numbers less than 6) - this means the Mom is not sensitized.
|
|
PCOS - LH is high or low?
|
high
|
|
What week can you confidently say fetal lungs are mature?
|
34
|
|
when to do penicillin desensitization?
|
pregnant pt has syphilis - erythromycin won't cross the placenta and help the baby
|
|
role of thyroid hormones and prolactin?
|
TRH stimulates prolactin
|
|
tx of variable decels
|
due to umb cord compression, so start O2 and change mom's position. if no help, amnioinfusion
if persists below 70bpm for a while, worry abt fetal hypoxia |
|
When to try to convert breech to vertex?
|
at 37th week - do external cephalic version
|
|
when to give mag sulfate in pt with mild preeclampsia?
|
during labor and within 24h of delivery
|
|
When to do C section in a pt with placental abruption
|
when there is another indication or fetus or mom is rapidly deteriorating
|
|
some main contraindications to vaginal delivery
|
placenta previa, dystocia, breech, prior c/s (for the most part), uterine rupture
|
|
What does ERT do to thyroid hormones?
|
more hepatic metabolism of them, more TBG, more volume of distrib of thyroid hormones
so you need to give more L-thyroxine in a ERT pt, just like in pregnancy |
|
Raloxifene - what it does, contraindications?
|
used to prev osteopor bc it increases bone mineral density. decreases risk of breast CA
it is thrombophilic - contraind with DVT breast and endometrial antagonist, bone agonist |
|
tamoxifen increases risk of...
|
endometrial CA
|
|
w/u of amenorrhea in premenopausal pt
|
1. preg test
2. prolactin and thyroid 3. estrogen status via progestin challenge |
|
Asherman's syndrome
|
after procedures, lots of scarring and the endometrium fails to respond to estrogen, infertility, etc
|
|
How PCOS affects HPA axis
|
abnormal gnrh secretion so lots of lh (which stimulates androgens) and not much FSH
|
|
mucus during ovulation
|
abundant, thin, stretches, ferns on microscopic slide
|
|
normal amniotic fluid index
|
5-25
|
|
when to do internal podalic version
|
twins - to convert the second baby from transverse or oblique to breech
|
|
OCPs in postpartum pt?
|
Don't use combined bc the estrogen can affect breast milk production
|
|
Pt has placenta previa and is stable - next course of action?
|
SCHEDULED c section with autologous blood available and close monitoring - but don't send them home
|
|
Vagismus what is it and tx?
|
very tight perineal muscles - can't have intercourse
tx - kegels, pelvic relaxation, inserting dilators or fingers |
|
what causes symmetric vs. asymmetric fetal growth restriction?
|
symm - congenital or chromosomal abnormalities or TORCH infections - things before week 28
asymm - HTN, toxins, smoking, etc. shunts blood to important organs (e.g. head) |
|
pH of amniotic fluid
|
7 - 7.5
|
|
pH of vagina
|
3.8 - 4.5
|
|
4 test results in aneuploidy
|
estriol - down
inhibin a - up hcg - up AFP - down ***up top HI five*** |
|
MCC increased AFP
|
inaccurate dates
|
|
in addition to AFP, what else is elevated with neural tube defects?
|
acetylcholinesterase
|
|
what to do with pregnant mom who has HIV
|
zidovudine to mom during preg and to neonate after birth
do an elective c section |
|
do OCPs cause weight gain?
|
no
|
|
most reliable measurement on US of fetal weight
|
abdominal circ - affected by symm and asymm fetal growth restriction
|
|
autoimmunity or immunodef associated with premature ovarian failure?
|
autoimmunity
|
|
placenta accreta - what is it? who is at risk? what surgery might they need?
|
placenta abnormally implants too far in uterine wall - common in pts who had c section in the past - they often need hysterectomy to stop the bleeding
|
|
uWISE - 18 y.o. with ASCUS and concerning hx - next step?
|
hpv typing - if highly oncogenic, get colpo
|
|
Findings in trichomoniasis
|
erythematous cervix, yellow d/c
|
|
cadidiasis in vagina - color of d/c?
|
white and cottage cheese
|
|
Justice - ?
|
treat all cases alike
|
|
Contraception options with <1% failure rate
|
dop provera, iud, sterilization, implanon
|
|
which immun contraind in pregnancy
|
mmr, vz
|
|
when start screening for breast ca
|
never earlier than 40
|
|
does RR change during preg?
|
NO!!!! but tidal volume does
|
|
plasma osmolality is increased or decreased in preg?
|
decreased
|
|
issue with using terbutaline (beta 2 agonist) or alpha agonist to stop uterine contractions?
|
increased risk of pulmonary edema
|
|
next step after diagnosing gestational trophoblastic disease
|
CXR (lungs are the most common site of metastases)
|
|
Congen dzs Jewish are more likely to have
|
Fanconi anemia, Tay-Sach's, Niemann-Pick, CF
|
|
serum marker that distinguishes quad screen from triple
|
inhibin a
|
|
pt has gestational DM - tx?
|
try diet modificationbefore insulin
|
|
is IUGR associated with gestational DM?
|
no, but it is with pre-existing DM
|
|
valproic acid - main AE to think about...
|
neural tube defects
|
|
obese woman - how much wt to gain in preg?
|
11-20 pounds
|
|
if you place an intrauterina pressure catheter and you get blood - next step?
|
assume you perforated the uterus. check the baby's status - if ok, you can put in the monitor
|
|
with use of mg sulfate in mother, what do you worry abt in child?
|
respiratory distress after birth
|
|
MCC post-partum fever
|
endometritis - espec after a c section
|
|
Time frame for PP blues
|
2 weeks - if greater, it may be PP depression
also with PP depression, pt may not care abt the newborn |
|
is cmplicated labor and deliv a RF for PP depression
|
no
|
|
mother is brestfeeding a baby and she develops very sensitive nipples with feeding, burning pain in breasts. tips of nips are pink and shiny and are peeling at the periph - dx?
|
candidiasis - inspect baby's oral cavity.
|
|
pt is hemodynamically unstable and has an abortion - how to get rid of fetus?
|
d&c - can only do misoprostol or expectant waiting if hemodyn stable
|
|
when to place cervical cerclage?
|
14 weeks
|
|
can you give metro during preg?
|
yes
|
|
ot with pulm htn - good prognosis during preg?
|
no - very dangerous - 25-50% mortality
|
|
pregnant woman has intermitt chest pain, palpitations; normal ekg - tx?
|
beta blockers for her MV prolapse
|
|
can get cxr in preg pt?
|
yes
|
|
how to relieve ureteral obstruction in pregnant pt
|
double j ureteral stent
|
|
how to tx severe lupus in pregnancy?
|
steroids
if mild, nsaids |
|
which ssri contraind in pregnancy?
|
paroxetine
|
|
Tx of pruritis gravidarum (variant of intrahepatic cholestasis of pregnancy)
|
1.) antihistamines
2.) ursodeoxycholic acid |
|
how to workup appendicitis in a pregnant pt
|
graded compression ultrasound
|
|
hypermagnesemia - common side effect
|
resp depression
|
|
pt has severe pre-eclampsia - platelet level < ___ makes you need to dewliver now?
|
100k
also deliver if oliguria, harm to fetus, can't control bp with two meds, lfts > 2x normal |
|
goal diastolic bp in a pt with severe preeclamp
|
90-100
|
|
Test to determine whether there is fetal anemia
|
middle cerebral artery peak systolic velocity
|
|
Baby is affected by Rh disease and is getting poor hepatic protein production - what will you see on US?
|
fetal hydrops - fluid in body cavities
|
|
delta OD450 measurement of amniotic fluid sample - what does it test for?
|
bilirubin - looking for hemolysis
|
|
what to do if baby is having severe hemolytic anemia but at 30 weeks
|
intraperitoneal transfusion into umb vein until mature
|
|
are congenital anomalies more common in twins?
|
yes
|
|
what kind of twins can get twin-twin transfusion syndrome?
|
monochorionic, monozygotic
|
|
biggest issue with multiple gestations
|
preterm birth
|
|
things you can use to dilate a cervix before giving oxytocin
|
misoprostol or PGE2
|
|
things associated with breech presentation
which kind of hydramnios? |
prematurity, multiple pregs, genetic disorders, polyhydramnios, hydrocephaly, anencephaly, previa, uterine fibroids
|
|
what is a prolonged latent phase?
|
before 4cm dilated - >20h if nulliparous and >14 ifmultiparous
|
|
what is prolonged active phase?
|
after 4cm dilated and no change in over 2h - tx with amniotomy
|
|
t/f? the more c sections in the past, the higher risk during vbac
|
true
|
|
risk factors for placenta accreta
|
low, anterior placenta and previous c sections
|
|
can bloody show/mucus plug cause bleeding for a while?
|
yes - e.g. 30 min
|
|
threatened abortion - can have it in 2nd or 3rd trimester?
|
no - only first
|
|
definition of preterm labor
|
regular uterine contractions LEADING TO CERVICAL CHANGE!!!
|
|
terbutaline and ritodrine - class of drug and purpose?
|
beta2 agonist - stop premature contractions
|
|
mg sulfate - contraind with what condition?
|
myasthenia gravis
|
|
side effects of mg sulfate
|
LOSS OF DEEP TENDON REFLEXES, resp depression, cardiac depression - things are less active
|
|
benefits of betamethasone for the baby
|
lung maturity, less incidence of intracerebral hemorrhage and necrotizing enterocolitis in the newborn.
|
|
best part of fetal fibronectin test -
|
great negative predictive value - if negative, the mom will almost definitely not deliver in the next 14 days.
|
|
cutoff for when you can give indomethacin
|
only before 32 weeks
|
|
biggest risk factor for PROM
|
genital tract infections - especially BV
|
|
what can give you 7 days of latency prolongation in a pt who had PROM
|
antibiotics
|
|
tender fundus is a sign of...
|
chorioamnionitis - probably want to deliver if you see it.
|
|
what does positive phosphatidylglycerol mean?
|
fetal lung maturity is there - can assume it is positive at 34 weeks.
|
|
what is better marker in amniotic fluid of infxn - low glucose or presence of leukocytes?
|
low glucose
|
|
what to do when you first see late decels and mom seems ok
|
move her to left lateral decubitus
|
|
is chorioamnionitis a risk factor for uterine atony?
|
yes - so is big uterus,general anes, prolonged labor
|
|
what is an agent that increases uterine contractions but is contraindicated in pts with HTN/preeclampsia
|
methylergonovine
|
|
definition of post partum hemorrhage
|
>500cc vaginal or 1L c section
|
|
first steps in management of PP hemorrhage
|
make sure uterus is firm, no retained placental tissue, look for lacerations
|
|
risk factors for retained placenta
|
prior section, fibroids, previous curettage of uterus, and succenturiate lobe of placenta.
|
|
IM - never IV!!!
|
how to administer PGF2 or methylergonovine
|
|
which artery can you ligate before you try hysterectomy in a pt with PPH
|
hypogastric (internal iliac)
|
|
can breast engorgement cause fever?
|
yes
|
|
can you take sertraline during preg?
|
no
|
|
does sertraline get in teh breast milk?
|
yes - but not in the baby
|
|
when in the cycle does premenstrual dysphoric disorder happen?
|
luteal phase - towards the end of it
|
|
things associated with postterm pregnancy
|
placental sulfatase deficiency, fetal adrenal hypoplasia, anencephaly
|
|
postterm preg associated with polyhydramnios or oligo?
|
oligo
|
|
when to do amnioinfusion?
|
not if there is meconium stained fluid, but rather if you see repetitive variable accelerations
|
|
tests to order when baby stops growing (3)
|
NST, amniotic fluid volume (bad if it is low), and systolic to diastolic umb artery pressures (bad if it is high - means lots of PVR in the baby)
|
|
is polycythemia associated with IUGR?
|
yes
|
|
IUGR is a risk factor for the baby developing...
|
CVDisease, chronic htn, copd, diabetes
|
|
is poorly controlled pre-existing DM a risk factor for congenital anomalies?
|
yes - but gestational DM is not.
|
|
boundaries of laceratsions - 1st to 4th
|
1 - vaginal mucosa
2 - vaginal fascia and perineum 3 - rectal partial or complete transection of the rectal sphincter 4 - sphincters and mucosa. |
|
definition of macrosomia
|
>4kg in diabetic and >4.5kg in non-diabetic
|
|
complications more likely to happentwith vacuum delivery vs. forceps
|
cephalohematoma (scalp dislocates off head), jaundice, lateral rectus paralysis.
|
|
when does irreg bleeding end after depo?
|
2-3 months
|
|
female sterilization is associated with reduced risk of...
|
ovarian cancer - not sure why
|
|
contraceptive patch - estrogen or progestin?
|
ethinyl estradiol and norelgestromin - so both
|
|
prolonged dilute russel viper venom - what does that mean?
|
antiphospholipid antibody syndrome - tx is asa and heparin
|
|
what has more blood loss - surgical elective termination or medical?
|
medical
|
|
when to do d&c vs. d&e
|
<16wks - d&c
16-24 weeks - d and evac |
|
how late can you do manual vacuum aspiration
|
<8wks
|
|
lichen sclerosis - signs/sx
|
polygonal ivory papules or figure of 8
vulvar pruritis fissures/erosions itch-scratch-itch cycle introital stenosis |
|
lichen planus - signs/sx
|
involves more than the vagina
remissions and flares can involve the vaginal canal (contrast to sclerosis) - more than the introitus |
|
tx of vulvar vestibulitis
|
tricyclic antidepressants, pelvic floor rehab, topic anesthesia
|
|
lichen simplex chronicus
|
chronic scratching/rubbing - often pruritis is worse at night
|
|
abx to tx chlamydia? gonorrohea?
|
c - azithro or doxy
g - ceftriaxone |
|
recurrent genital herpes infxn - more likely hsv1 or 2?
|
2
|
|
bladder contracts while filling - what sort of incontinence?
|
urge
|
|
pt has urethral sphincteric deficiency - tx options?
|
urethral bulking is first, do an artificial sphincter last line.
|
|
colpocleisis - what is it?
|
procedure where the vagina is surgically obliterated but you can do it under local. good for vaginal/uterine prolapse
|
|
post menopausal pt has ovarian mass - next step?
|
exploratory surgery
|
|
tx ovarian torsion?
|
surgery
|
|
tx of infertility caused by endometriosis
|
1.) clomiphene +/- IUI
2.) laparoscopy to remove lesions |
|
young pt has history concerning of endometriosis - failed nsaids and ocps - next step?
|
laparoscopy
don't do gnrh agonist until you confirm the dx of endometriosis |
|
clomiphene mech of action
|
estrogen antag at pituitary so there is no negative feedback
|
|
what is pelvic congestion?
|
chronic pelvic pain due to pelvic varicosities
|
|
mech of action of danazol in treating endometriosis
|
testosterone deriv - suppresses lh and fsh mid cycle surges so no estrogen release
|
|
best way to measure prolactin?
|
fasting - and touching the breast can elevate the level
|
|
___can increase pain during cyclic mastalgia due to fibrocystic breast changes
|
caffeine
|
|
if breast mass has bloody discharge, next step?
|
excision biopsy!!!
|
|
abx for mastitis
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1.) dicloxacillin
2.) erythromycin if they are pen allergic |
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if you do FNA of a breast mass and it comes up negative, next step?
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excisional biopsy - FNA often can have false negatives
|
|
what is adrenarche?
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hair growth
|
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3 things that can delay puberty
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low weight, poor sleep, little sunlight exposure
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what happens if you have partial deletion of the long arm of chrom x?
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premature ovarian failure
|
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how to tx precocious puberty
|
gnrh agonist - only treat if they are pretty far from "normal"
e.g. 8 year old - treat |
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normal age for menarche
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9-17
|
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tx of congenital adrenal hyperplasia
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steroid replacement
|
|
mullerian agenesis - signs/sx
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absent uterus and cervix, primary amenorrhea, XX karyotype, RENAL ANOMALIES!!!
therefore the test to confirm is a renal ultrasound |
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with anorexia - what happens to levels of gonadotropins
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hpa dysfunction so low fsh and lh
|
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pt has amenorrhea after stopping ocps - what part of history is important?
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cycles before ocps - she may have post-pill amenorrhea if they were irregular before then.
|
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does CAH cause hirsutism?
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yes
|
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high estrogen level withdrawal after preg can lead to what cosmetic issue?
|
hair loss
|
|
sertoli-leydig cell tumors - where are they found?
|
can be found on an ovary
|
|
what is hyperthecosis?
|
a more severe form of PCOS
|
|
long term side effect of leuprolide
|
osteoporosis - so don't use it over 6 months
|
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what is dysfunctional uterine bleeding?
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irreg/increased menstrual bleeding without a clear etiology
|
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how do OCPs relieve primary dysmenorrhea?
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progestin sheds the endometrium, and that is what makes prostaglandins
|
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steps in treatment of dysmenorrhea in a yonug pt
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ibuprofen
ocps depo laparoscopy looking for endometriosis or gnrh agonist |
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first line medical tx for adenomyosis
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gonadotropin releasing agents
|
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can you tx osteoporosis without a dexa scan?
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yes - e.g. had a pathologic fracture
|
|
raloxifene - will it improve hot flashes?
|
no - may actually worsen them
|
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what does HRT do for serum lipids?
|
good things - less LDLs, more HDLs
|
|
test of choice to eval for mets after early detection of endometrial ca
|
cxr
|
|
AE of imipramine
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hyperprolactinemia
|
|
how can you confirm exercise induced amenorrhea
|
check estrogen levels (should be low)
|
|
use of clomiphene challenge test
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to determine ovarian reserve - good if old lady isn't fertile
|
|
deficiencies of what vitamins can increase PMS?
|
A, E, B6
|
|
whic is worse, PMS is PMDD?
|
pms = premenstrual syndrome
pmdd = premenstrual dysphoric disorder - this one is worse |
|
tx of pms
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OCPs (suppresses the HPA axis)
|
|
risk factors for PMS
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vit A, E, b6, calcium or mg deficiency. fam hx. other mood disorders. increasing age
|
|
risk factors for molar pregnancies
|
asian, <20 or >40, low folic acid or beta carotene intake
|
|
best test to rule out molar preg
|
quant hcg
|
|
treatment of a molar preg
|
suction curettage
|
|
describe a partial mlar preg?
|
69XXY - fetus is present in there and lower risk of developing post-molar GTD
partial - fetus is there - it's not all molar |
|
how quickly can you get pregnant again after a molar preg?
|
6 months after hcg reaches 0 - should take ocps in the meantime - you don't want to confuse a new pregnancy with a recurrence of teh molar
|
|
how to treat recurrent trophoblastic disease
|
chemotherapy
|
|
should you biopsy a lesions suspicious for metastatic choriocarcinoma?
|
no - very vascular. just get quant hcg instead
|
|
vulvar intraepithelial neoplasia is associated with what virus?
|
hpv
|
|
what is trichloroacetic acid used for?
|
warts (note - not VIN!!!)
|
|
paget's disease of the vulva - what does it look like? any risk factors?
|
fiery red background with bague white hyperkeratotic areas
assoc with breast ca |
|
how often to do paps in woman with hiv
|
twice in the first year - if normal, annual after that
|
|
what is an ectropion
|
typically with cervix - area of columnar epithelium that has not yet undergone squamous metaplasia
|
|
what do you do if there is a lesion extending into endocervical canal?
|
bx with cold knife cone
|
|
if there is huge difference btwn pap smear results and bx results - next step?
|
cervical conization - need to be aggressive
|
|
when is cervical conization indicated?
|
cervical bx shows severe dysplasia, CIS, or a positive endocervical curettage
|
|
main sx associated with fibroids
|
menorrhagia
|
|
how to tx fibroids symptomatically?
|
gnrh agonists can be good bc the fibroid is estrogen responsive - so this is useful in a pt who is going to get surgery soon or will have menopause soon
6 months max can always try nsaids first, too |
|
what to do for an infertile pt who has fibroids
|
myomectomy
|
|
risk factors for ovarian ca
|
family, white, more periods in lifetime
NOT SMOKING!!! |
|
do ocps reduce risk of ovarian ca?
|
yes
|
|
which is typically bigger - serous cystadenoma or functional cyst?
|
serous cystadenoma - pt may have increasing abdominal girth
|
|
serous cystadenoma or mucinous - which tend to be multilocular?
|
mucous
|
|
difference btwn stage and grade
|
stage - most important for ovarian ca -
grade - histology |
|
standard of care - after you resect an ovarian cancer, next step?
|
chemotherapy - even if you got all of it
|
|
most common tumor in women of all ages
|
dermoid - on ultrasound there will be cystic and solid components
|
|
use of oral progesterone in a postmenopausal pt
|
decrease hot flashes
|
|
young girl is on abx and now has linear abrasions on her vulva - dx?
|
yeast infection - give antifungals
|
|
course of action when you have an adult rape victim
|
offer abx prophylaxis, screen for STDs, offer emergency contraception, colect forensic specimens, preg test
|
|
shockwave lithotripsy - ok in pregnancy?>
|
NO!!!
|
|
McCune-Albright syndrome - what is their puberty like?
|
early - gonadotropin independent
|
|
test to get ifg you are suspecting gestational trophoblastic disease
|
quant hcg
|
|
adequate cervical length?
|
>25mm at 24 weeks
|
|
prolacting suppresses ___
|
gnrh
|
|
Tx of DUB
|
mild - iron
mod with no active bleeding - progestin mod with active bleeding - estrogen severe and unstable - D&C and transfusion |
|
mcc DUB
|
anovulation - it is a diagnosis of exclusion
|
|
tx of postpartum endometritis
|
gent and clinda - polymicrobial
|
|
when in menstrual period should a benign breast lump go aaway?
|
after the period is over
|
|
mech of action of epidural causing hypotension
|
sympathetic fiber block --> vasodilation --> blood pooling in veins - especially in lower extremities
no cns involvement - all peripheral |
|
tx of mag sulfate overdose
|
stop the mg sulfate and calcium gluconate
|
|
anesthesia can prolong labor if given in the ____ stage
|
latent
|
|
endometritis - more3 common after vaginal deliv or c section?
|
c section
|
|
steps when thinking of arrest of labor
|
membranes ruptured?
give ptocin - adeequate contractions via IUPC? |
|
terbutaline and ritodrine contracindicated in pts with...
|
diabetes
|