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18 Cards in this Set

  • Front
  • Back
plt disorder vs coag factors
manifestations
plt = petechiae
coag = hemarthroses
intrinsic path
measured by
initiated by
affected by which drug
measure PTT
initiate = exposure to collagen after vascular trauma
affected by heparin
extrinsic path
measured by
initiated by
affected by which drug
measure PT
initiate = tissue factor from endothelium
affected by warfarin
factors affected by warfarin
protein C, prot S (causes initial hypercoag'y)

vit K dependent 1972 =
10, 9, 7, 2
cryoprecipitate
contains?
factor 8, 9
vWF
fibrinogen
fibronectin
hemophilia C
factor 11 deficiency
ashk jews
secondary eosinophilia
causes
NAACP
neoplasm, allergy, asthma,
collagen vasc dx (Churg-Straus)
parasites
eosinophilic
normal level?
cytokines?
normal < 350
cytokines IL3, 5, GM-CSF
primary eosinophilia
causes
hyper-eosinophilic syndrome
hereditary eosinophilia
eosinophilia - myalgia syndrome (abn tryptophan metab)
elevated eosinophils
why analyze CSF?
infection
coccidio-mycosis
helminth
hematuria with eosinophilia suggests?
schisto-somiasis
autologous transplant
allogenic
syngeneic
pt to self
donor to genetically diff pt
btw identical twins
matching with allogenic transplant
ABO
HLA
pathomech for the 3 types of transplant rejection
hyperacute = immed = preformed ab's
acute = days - months = t-cell mediated
chronic = months - years = chronic immune rxn --> fibrosis
GVHD
graft vs host dx
cause?
presentation?
allogenic transplant
donor T-cells attack host tissues
presents with skin changes, cholestatic liver dysfn, obstructive lung dx, GI prob
graft-vs- leukemic effect
leukemic pt, allogenic bone marrow transplant
signif lower relapse than those with autologous transplant
due to rxn of donor Tcells against leukemic cells
hemophilia
presentations
spontaneous hemmorrhage
joints and tissues
intracerebral
retroperitoneal
hemophilia
lab studies
PT normal
PTT prolonged
bleeding time normal
thrombin time, fibrinogen norm
factor assays (7, 8, 9, 11, 12)
mixing studies - PTT returns to normal if hemophilia