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35 Cards in this Set
- Front
- Back
MCC of aortic stenosis in a 70 y/o
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senile (i.e. degenerative) calcifications
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labs in DIC
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ELEVATED:
fibrin-split products D-dimers DECREASED: fibrinogen platelets hematocrit |
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which type of RTA is a/w abnormal H+ secretion & nephrolithiasis
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RTA I
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what is the classic presentation of polycythemia vera
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thrombosis
erythromelalgia (i.e. burning pain in hands & feet) pruritis (esp after warm bath/shower) facial plethora hepatosplenomegaly visual disturbances abnormal labs |
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what visual distrubances are seen with polycythemia vera
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blurred vision
amaurosis fugax scintillating scotoma ophthalmic migraine |
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what lab abnormalities are seen with polycythemia vera
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elevated H&H
elevated red cell mass basophilia leukocytosis (40%) thrombocytosis (60%) |
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what is the tx for polycythemia vera
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phlebotomy
(FYI: induces a desirable iron def anemia --> DO NOT supplement with iron) |
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what is used in pt with polycythemia vera with high risk of thrombosis; which pts are considered "at risk"
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hydroxyurea
"AT RISK": h/o thrombosis plts > 1,500,000 CV RF+ > 70 y/o |
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what is used in pt with polycythemia vera with refractory pruritis or refractory erythrocytosis
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IFN-a
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what tests will help in dx of MM
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SPEP: monoclonal AB spike
UPEP: bence-jones proteins BM BX: incr'd plasma cells |
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Dx
pt with weight loss, pruritis, night sweats, hepatosplenomegaly, nontender cervical lymphadenopathy |
Hodgkin's lymphoma
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Dx:
3 y/o girl presents with abd'l mass, hematuria, & HTN |
Wilm's tumor
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Dx & Tx:
recent Cuban immigrant with sx's of malabsorption is found to also have megaloblastic anemia |
Dx: Tropical sprue
Tx: folate & antibiotics (e.g. tetracycline or sulfa) |
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cell pathology a/w:
EBV |
Burkitt's lymphoma
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cell pathology a/w:
reed sternberg cell, cervical lymphadenopathy, night sweats |
Hodgkin's lymphoma
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cell pathology a/w:
bence jones proteins, osteolytic lesions, high Ca2+ |
MM
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cell pathology a/w:
translocation 14:18 |
follicular lymphoma
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cell pathology a/w:
MC lymphoma in US |
diffuse large B cell lymphoma
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cell pathology a/w:
translocation 8:14 |
burkitt's lymphoma
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cell pathology a/w:
translocations 9:22 |
philadelphia (CML or ALL)
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cell pathology a/w:
MC hodgkin lymphoma |
nodular sclerosing
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cell pathology a/w:
starry sky pattern due to phagocytosis of apoptotic tumor cells |
burkitt's lymphoma
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cell pathology a/w:
high H&H, pruritis (esp after hot bath or shower), burning pain in hands or feet |
polycythemia vera
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cell pathology a/w:
white cells with hair-like projections & splenomegaly |
hairy-cell leukemia
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cell pathology a/w:
macrocytosis, hypogranular granulocytes with bilobed nuclei |
myelodysplastic syndrome
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Rx for CML
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imatinib (95% remission rate)
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leukemia a/w:
MC in children (peak age 3-4 y/o) |
ALL
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leukemia a/w:
MC in adults (avg age of onset 50 y/o) |
CLL
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leukemia a/w:
philadelphia Chromosome is always present |
CML
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leukemia a/w:
smudge cells |
CLL
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leukemia a/w:
peripheral blasts are PAS+ and TdT+ |
ALL
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leukemia a/w:
peripheral blasts are PAS-, MPO+ and have Auer rods |
AML
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leukemia a/w:
pancytopenia in a down syndrome px |
ALL
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Markers: ALL |
PAS+ blasts TdT+ blasts CALLA+ MPO- |
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Markers: AML |
Auer rods present MPO+ PAS- blasts TdT- blasts CALLA- |