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35 Cards in this Set

  • Front
  • Back
MCC of aortic stenosis in a 70 y/o
senile (i.e. degenerative) calcifications
labs in DIC
ELEVATED:
fibrin-split products
D-dimers

DECREASED:
fibrinogen
platelets
hematocrit
which type of RTA is a/w abnormal H+ secretion & nephrolithiasis
RTA I
what is the classic presentation of polycythemia vera
thrombosis

erythromelalgia (i.e. burning pain in hands & feet)

pruritis (esp after warm bath/shower)

facial plethora

hepatosplenomegaly

visual disturbances

abnormal labs
what visual distrubances are seen with polycythemia vera
blurred vision

amaurosis fugax

scintillating scotoma

ophthalmic migraine
what lab abnormalities are seen with polycythemia vera
elevated H&H

elevated red cell mass

basophilia

leukocytosis (40%)

thrombocytosis (60%)
what is the tx for polycythemia vera
phlebotomy
(FYI: induces a desirable iron def anemia --> DO NOT supplement with iron)
what is used in pt with polycythemia vera with high risk of thrombosis; which pts are considered "at risk"
hydroxyurea

"AT RISK":
h/o thrombosis
plts > 1,500,000
CV RF+
> 70 y/o
what is used in pt with polycythemia vera with refractory pruritis or refractory erythrocytosis
IFN-a
what tests will help in dx of MM
SPEP: monoclonal AB spike

UPEP: bence-jones proteins

BM BX: incr'd plasma cells
Dx
pt with weight loss, pruritis, night sweats, hepatosplenomegaly, nontender cervical lymphadenopathy
Hodgkin's lymphoma
Dx:
3 y/o girl presents with abd'l mass, hematuria, & HTN
Wilm's tumor
Dx & Tx:
recent Cuban immigrant with sx's of malabsorption is found to also have megaloblastic anemia
Dx: Tropical sprue

Tx: folate & antibiotics (e.g. tetracycline or sulfa)
cell pathology a/w:
EBV
Burkitt's lymphoma
cell pathology a/w:
reed sternberg cell, cervical lymphadenopathy, night sweats
Hodgkin's lymphoma
cell pathology a/w:
bence jones proteins, osteolytic lesions, high Ca2+
MM
cell pathology a/w:
translocation 14:18
follicular lymphoma
cell pathology a/w:
MC lymphoma in US
diffuse large B cell lymphoma
cell pathology a/w:
translocation 8:14
burkitt's lymphoma
cell pathology a/w:
translocations 9:22
philadelphia (CML or ALL)
cell pathology a/w:
MC hodgkin lymphoma
nodular sclerosing
cell pathology a/w:
starry sky pattern due to phagocytosis of apoptotic tumor cells
burkitt's lymphoma
cell pathology a/w:
high H&H, pruritis (esp after hot bath or shower), burning pain in hands or feet
polycythemia vera
cell pathology a/w:
white cells with hair-like projections & splenomegaly
hairy-cell leukemia
cell pathology a/w:
macrocytosis, hypogranular granulocytes with bilobed nuclei
myelodysplastic syndrome
Rx for CML
imatinib (95% remission rate)
leukemia a/w:
MC in children (peak age 3-4 y/o)
ALL
leukemia a/w:
MC in adults (avg age of onset 50 y/o)
CLL
leukemia a/w:
philadelphia Chromosome is always present
CML
leukemia a/w:
smudge cells
CLL
leukemia a/w:
peripheral blasts are PAS+ and TdT+
ALL
leukemia a/w:
peripheral blasts are PAS-, MPO+ and have Auer rods
AML
leukemia a/w:
pancytopenia in a down syndrome px
ALL

Markers: ALL

PAS+ blasts


TdT+ blasts


CALLA+


MPO-

Markers: AML

Auer rods present


MPO+


PAS- blasts


TdT- blasts


CALLA-