Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
200 Cards in this Set
- Front
- Back
How does RCC cause thrombocytosis and polycythemia?
|
Increased EPO
|
|
Blood streaked sputum and multiple lung cavities on CXR
|
Acute necrotizing PNA with secondary pneumatoceles
|
|
Which pathogen causes post-viral URI necrotizing pulmonary beonchopenumonia w/ multiple nodular infiltrates
|
S. aureus
|
|
Cause of gall stones in pts on TPN
|
Decreased gallbladder contraction (b/c no stimulus from CCK)
|
|
Why are women more predisposed to gall stones?
|
Estrogen promotes formation by stimulating activity of HMG-CoA reductase
|
|
Test for comparing two proportions (e.g. this number out of 100 have disease)
|
Chi-square
|
|
Test for comparing means
|
Two sample t-test
|
|
Nephrotic syndrome in pt with RA, enlarged kidneys, and hepatomegaly is most likely due to
|
Amyloidosis
|
|
Renal biopsy findings in amyloidosis
|
Deposits w/ apple-green birefringence under polarized light after staining w/ congo red
|
|
Renal biopsy w/ crescent formation on light microscopy
|
RPGN
|
|
Renal biopsy w/ linear immunoglobulin deposits on immunofluoresence
|
Anti-GBM disease (e.g. Goodpasture's)
|
|
Renal biopsy w/ granular deposits on immunofluoresence
|
Immune complex glomerulonephritis (e.g. lupus or post-strep GN)
|
|
Two areas most at risk in ischemic colitis
|
Splenic flexure (between SMA and IMA)
Recto-sigmoid junction (supplied by narrow terminal branches of IMA) |
|
Hypopigmented plaque on skin w/o sensation, followed by muscle atrophy
|
Leprosy
|
|
How to diagnose leproxy
|
Acid-fast bacilli on skin biopsy
|
|
Asthma, chronic rhinosinusitis w/ nasal polyosis, and bronchospasm or congestion after aspirin or NSAIDs
|
Aspirin exacerbated respiratory disease (AERD)
|
|
Bland tasting food and recurrent nasal discharge/congestion
|
Nasal polyps (bland tasting food is due to anosmia)
|
|
Nasal discomfort and excess crusting/ bleeding
|
Perforated nasal septum
|
|
Risk factor for perforated nasal septum
|
Intranasal cocaine
|
|
Frequent cause of nose bleeds during pregnancy
|
Increased incidence of pyogenic granulomas on anterior nasal septum
|
|
Ductopenia (lack of bile ducts) is most commonly due to
|
Primary biliary cirrhosis
|
|
Liver w/ periductal portal tract fibrosis and segmental stenosis of extra/intra hepatic bile ducts
|
Primary sclerosing cholangitis
|
|
How to treat iron deficiency in dialysis pts
|
IV (iron dextran)
|
|
Clubbing in pt with COPD suggests
|
Occult malignancy (clubbing is NOT a feature of simple COPD)
|
|
Causes of clubbing (6)
|
Pulmonary HTN and hypoxemia (from congenital heart disease, not COPD)
Lung abscess Bronchiectasis CF Interstitial lung disease |
|
Why do pts with acromegaly develop acanthosis?
|
They also have insulin resistance
|
|
Sudden appearance of acanthosis may indicate
|
GI malignancy
|
|
Lung lesion that moves with position change
|
Aspergilloma (fungus ball, lies free in the lung cavity)
|
|
Lung lesion with an air fluid level
|
Lung abscess
|
|
CXR with calcified nodes in lung/mediastinum (or spleen/liver)
|
Histoplasmosis
|
|
EKG finding most specific for digitalis toxicity
|
Atrial tachycardia (from ectopy) PLUS AV block
|
|
Liver biopsy w/ macrovesicular steatosis, polymorphonuclear cellular infiltrates, and necrosis
|
NASH or ASH
|
|
Anti-mitochondrial antibodies
|
Primary biliary cirrhosis
|
|
Anti-smooth muscle Abs
|
Autoimmune hepatitis
|
|
Study with 2+ experimental interventions as well as multiple groups w/ different treatment endpoints (2+ variables studied independently)
|
Factorial design study
|
|
What is cluster analysis?
|
Randomization at level of groups rather than individuals
|
|
Acute onset of back pain w/o obvious trauma + local tenderness on PEX
|
Compression fracture of vertebrae
|
|
Injury caused by less dramatic physical strain w/ paravertebral muscle tenderness (not spinal)
|
Lumbago
|
|
Rx for acne patient who has begun scarring
|
Oral isotretinoin
|
|
Best study type for calculating incidence
|
Cohort
|
|
Pt treated with a sulfa antibiotic who then presents with hemolysis
|
G6PD deficiency
|
|
Cause of hemolytic episodes in G^PD deficient pts
|
Infections or meds (sulfa drugs, antimalarials, nitrofurantoin) that increase oxidative stress
|
|
Finding on urine stain during G6PD hemolytic episode
|
Prussian blue stain (indicating presence of hemosiderin)
|
|
Pathophys of G6PD deficiency
|
Can't catalyze reduction of NADP --> NADPH, which is necessary to form reduced glutathione, which protects RBCs from oxidative injury
|
|
Pts with Strep bovis endocarditis or septicemia are at increased risk of
|
Occult colorectal or upper GI cancer
|
|
EKG: tachy w/ regular, narrow QRS complexes w/o definite p waves
|
Supraventricular tachycardia
|
|
Rx for SVT
|
Adenosine
|
|
Wide QRS complex tachycardia
|
Ventricular tachy
|
|
Rx for ventricular tachy (general)
|
Amiodarone, lidocaine, etc.
|
|
Management of pt about to undergo splenectomy (2)
|
Anti-pneumococcal, Haemophilius, and meningococcal vaccines several weeks preop
Daily oral penicillin prophy for 3-5 yrs after surgery |
|
Lab test that can distinguish septic shock from other types of distributive shock (neurogenic, hypovolemic)
|
MVO2: typically low in distributive, due to increased oxygen extraction by hypoperfused tissues, but normal in septic shock due to hyperdynamic circulation/ improper distribution of CO
|
|
Excess immunoglobulins seen in multiple myeloma vs. Waldenstrom's
|
IgG or IgA in multiple myeloma
IgM in Waldenstrom's |
|
Why do Waldenstrom's pts have dilated retinal veins?
|
Hyperviscosity (not seen in multiple myeloma)
|
|
Treating H pylori can help cure what type of GI cancer (specific)
|
Gastric lymphoma (NOT gastric adenocarcinoma)
|
|
Which pulmonary-renal syndrome requires emergency plasmapheresis to minimize the extent of kidney damage?
|
Goodpasture's syndrome (take off anti-GBM antibodies)
|
|
Rx for Wegener's
|
Cyclophosphamide and steroids
|
|
Another name for Wegener's?
|
Granulomatosis with polyangitis
|
|
Ganciclovir is most commonly used to treat
|
CMV
|
|
Pathophys of NASH
|
Insulin resistance
|
|
Weight loss, gynecomastia, testicular atrophy, impotence
|
Chronic liver failure (latter three from hyperestrogenemia since estrogens aren't adequately cleared and there is decreased synthesis of SHBG)
|
|
Cirrhosis can cause what endocrine problem?
|
Hypothalamic-pituitary dysfunction (e.g. lack of TSH response to low thyroid hormone levels)
|
|
A sudden aversion to smoking may indicate
|
Hepatitis
|
|
Rx for Hep A
|
Supportive
Immune globulin for close contacts |
|
Rx for primary biliary cirrhosis
|
Ursodeoxycholic acid (also MTX and colchicine)
|
|
Rx for resistant PBC
|
Liver transplant (once disease is advanced)
|
|
Recurrent oral and genital ulcers, anterior uveitis, and erythema nodosum
|
Behcet's Syndrome
|
|
How is cysticercosis transmitted?
|
NOT by eating infected pork. Rather, by ingesting the feces of someone who has eaten pork with Taenia solium eggs.
|
|
Chem abnormality after a seizure?
|
Lactic acidosis from the seizure --> post-seizure anion gap metabolic acidosis that resolves w/in 60-90 min
|
|
Abx choice for emphysematous cholecystitis
|
Coverage for Clostridium (amp-sulbactam, zosyn, or an aminoglycoside + clinda)
|
|
High fever, jaundice, and RUQ pain
|
Charcot's triad (acute cholangitis)
|
|
Localize the lesion for cauda equina syndrome
|
Nerve root injury
|
|
Pts with hemochromatosis and cirrhosis are at increased risk of infection with what 3 bacteria?
|
Listeria, Yersinia, and Vibrio vulnificus
|
|
What test is required before starting trastuzumab adjuvant treatment for breast cancer?
|
Echo (b/c risk of cardiac toxicity, esp in combo w/ chemo, and pts w/ EF <55% are at higher risk)
|
|
Rx for SVT in a pt with unstable vitals or refractory chest pain
|
DC cardioversion
|
|
Pt with sickle cell trait and nocturia
|
Hyposthenuria
|
|
What is hyposthenuria?
|
Impaired ability to concentrated urine (likely from RBC sickling in vasa rectae of medulla)
|
|
Dreaded complication of retropharyngeal abscess and 2 measures to prevent it
|
Spread into mediastinum
IV Abx and urgent drainage |
|
What is herpangina and what virus causes it?
|
Formation of vesicles on the tonsils and soft palate
Coxsackie A virus |
|
Rx for a pt w/ uremic pericarditis 2/2 renal failure
|
Hemodialysis
|
|
6 indications for hemodialysis
|
1) Refractory hyperK
2) Volume overload/pulm edema refractory to diuretics 3) Refractory metabolic acidosis (pH <7.2) 4) Uremic pericarditis 5) Uremic encephalopathy/ neuropathy 6) Coagulopathy due to renal failure |
|
Immunocompromised host w/ bilateral difffuse interstitial infiltrates
|
Pneumocystis jiroveci
|
|
Zofran (ondansetron)'s mechanism
|
Serotonin (5HT3) antagonist
|
|
2 most common causes of cellulitis
|
Staph aureus and beta-hemolytic strep
|
|
Rx for cellulitis w/ systemic signs (high fevers, confusion, etc.)
|
IV nafcillin or cefazolin
|
|
Common nidus for LE cellulitis
|
Tinea pedia
|
|
Rx for organophosphate poisoning
|
Atropine (anticholinergic) and wash whole body
|
|
Two non-renal risks of nephrotic syndrome
|
Lipid abnormalities (high LDL/low HDL: risk of atherosclerosis) and hypercoagulability
|
|
Chloride and bicarb in pt w/ obesity hypoventilation syndrome
|
Compensate for respiratory acidosis by retaining bicarb (high), which causes chloride excretion (low)
|
|
Rx for hemochromatosis pts who can't udnergo phlebotomy
|
Deferoxamine
|
|
Hypercalcemia w/ recurrent peptic ulcers
|
MEN1 (hyperparathyriodism and pnacreatic gastrinoma)
|
|
Rx for acute COPD flare (4)
|
Bronchodilator (beta-adrenergic agonist e.g. albuterol), antimuscarinic (ipratropium), broad spectrum Abx, 2wk steroid taper
|
|
Chem-7 abnormality in Cushing's
|
Hypokalemic alkalosis
|
|
Rash of Lyme vs. secondary syphilis
|
Erythema migrans is on arms, abdomen, or moist areas and has central clearing
Syphilis is scaly red papules on trunk/extremities (incl palms/soles) |
|
Difference between 2 sample t test and z test?
|
T: two groups
Z: two populations |
|
Anaphylaxis to blood transfusion may indicate
|
IgA deficiency
|
|
Rx for anaphylaxis from blood transfusion (4)
|
Stop transfusion, epi, IV fluids, vasopressors
|
|
Pt w/ bacterial endocarditis w/ hemoptysis, chest pain, and numerous round alveolar infiltrates on CXR
|
Septic pulmonary emboli
|
|
Pt w/ bacterial endocarditis w/ proteinuria
|
Septic emboli to kidneys
|
|
Tricuspid endocarditis causes what murmur?
|
Tricuspid regurg (systolic murmur that increases w/ inspiration)
|
|
Systolic murmur that increases w/ standing
|
HOCM
|
|
Paradoxical splitting of S2
|
LBBB (due to delayed closure of aortic valve)
|
|
Pleural fluid protein count in exudates vs. transudates
|
Higher in exudates
|
|
Low pH pleural fluid: diagnosis and management
|
Likely empyema
Needs drainage |
|
Management of pleural fluid w/ glucose <60
|
Needs drainage
|
|
Milky white pleural effusion is likely due to
|
Ruptured thoracic duct
|
|
How to differentiate hereditry spherocytosis from autoimmune hemolytic anemia (both have spherocytes)
|
+ osmotic fragility test vs. + Coomb's test
|
|
Two types of autoimmune hemolytic anemia
|
Warm-agglutin (IgG)
Cold-agglutin (IgM) |
|
Heinz bodies on peripheral smear indicate
|
G6PD deficiency
|
|
D-xylose absorption test
|
Requires only intact mucosa, so normal in pancreatic insufficiency and terminal ileal disease
Decreased in bacterial overgrowth but improves w/ Abx Decreased in celiac disease |
|
Inpatient CAP Rx
|
Levofloxacin or moxifloxacin
|
|
Outpatient CAP Rx
|
Azithromycin or doxycycline
|
|
Rx for hairy cell leukemia
|
Cladribine (purine analog)
|
|
Rx for non-Hodgkin's lymphoma
|
CHOP
|
|
Rx for CLL
|
Chlorambucil and prednisone
|
|
Common bone marrow aspiration finding in hairy cell leukemia pts and why
|
Dry tap: fibrotic BM
|
|
What is use dependence and what anti-arrhythmics display it?
|
More effective at higher HRs b/c med has less time to dissociate from receptosr
Class I and IV anti-arrhythmics |
|
Diabetic pt w/ necrotic nasal turbinates
|
Mucormycosis (usually from fungus Rhizopus)
|
|
Rx for Mucormycosis
|
Surgical debridement + IV amphotericin B (only effective drug)
|
|
Characteristics of the arthritis in SLE (2)
|
Very painful
Non-deforming |
|
Young pt w/ neuro abnormalities (incl extensor weakness), abdominal pain, renal disease, and anemia
|
Lead poisoning
|
|
Tick borne illness w/ leukopenia/ thrombocytopenia and elevated LFTs, but no rash
|
Ehrlichiosis ("spotless RMSF")
|
|
Rx for erlichiosis
|
Doxycycline
|
|
Rx for tinea versicolor (2)
|
Selenium sulfide lotion and ketoconazole shampoo
|
|
Cause of pseudogout
|
Release of calcium pyrophosphate dehydrate (CPPD) crystals from sites of chondrocalcinosis in joint space
|
|
Best intervention to prevent enlargement of AAA
|
Smoking cessation
|
|
Rx for HTN in pt with AAA
|
Beta blocker
|
|
Retrosternal chest pain with aortic regurg
|
Aortic dissection
|
|
Diagnostic test for suspected aortic dissection
|
TEE
|
|
HIV drug associated w/ nepropathy
|
Indinavir (protease inhibitor) --> crystal-induced nephropathy
|
|
HIV drug associated w/ pancreatitis
|
Didanosine
|
|
HIV drug associated w/ hypersensitivity
|
Abacavir
|
|
HIV drug associated w/ liver failure
|
Nevirapine
|
|
HIV drug class associated w/ lactic acidosis
|
NRTIs
|
|
HIV drug class associated w/ Stevens-Johnson syndrome
|
NNRTIs
|
|
Widened mediastinum on CXR in Marfan's pt
|
Aortic dissection
|
|
Splenomegaly and pruritis after showering
|
Polycythemia vera
|
|
Myeloproliferative disorder with painful swollen toe
|
Gout (MPDs cause uric acid overproduction from increased purine turnover)
|
|
How does chronic kidney disease cause gouty attacks?
|
Decreases amount of uric acid excreted in urine
|
|
HIV pt with chronic bloody diarrhea, abdominal pain, and normal stool culture
|
CMV colitis
|
|
Rx for CMV colitis
|
Ganciclovir
|
|
Colonic biopsy with large cells w/ eosinophilic intranuclear and basophilic intracytoplasmic inclusions
|
Owl's eyes: CMV colitis
|
|
Irregular vaginal bleeding, pelvic pain, and an enlarged uterus postpartum
|
Gestational trophoblastic disease
|
|
Rx for aortic dissection
|
BP control w/ IV labetalol (beta blockers simultaneously lower HR and BP)
|
|
Which type of dissections require surgery in addition to medical therapy
|
Type A (involve ascending aorta)
(Type B doesn't: descending aorta only) |
|
Most common pathogen in osteomyelitis from a nail puncture wound
|
Pseudomonas
|
|
Painless blisters, increased skin fragility on dorsal hands, facial hypertrichosis and hyperpigmentation
|
Porphyria cutanea tarda
|
|
2 substances that can trigger porphyria cutanea tarda
|
Ethanol
Estrogens |
|
Pathophys of porphyria cutanea tarda
|
Deficiency of uroporphyrinogen decarboxylase (part of heme synthesis pathway)
|
|
Common infection that co-occurs w/ porphyria cutanea tarda
|
HCV
|
|
Rx for porphyria cutanea tarda (3)
|
Phlebotomy or hydroxychloroquine
Interferon-alpha in pts w/ HCV |
|
Where is lung ventilation and perfusion the greatest?
|
Most dependent location (usually lung bases; when on their side, pts lower lung)
|
|
What is susceptibility bias?
|
Type of selection bias
Treatment regimen selected for a pt depends on severity of their condition |
|
S/p angiography w/ blue skin on the toes, livedo reticularis, acute renal fialure, and nausea/abd pain
|
Cholesterol embolization
|
|
Two lab abnormalities in cholesterol embolization
|
Increased eosinophils
Decreased complement levels |
|
Pathophys of edema in heart failure
|
Decreased circulating blood volume --> renal hypoperfusion --> renal arteriolar constriction --> sodium reabsorption --> water retention
|
|
How to distinguish anemia of chronic disease from iron deficiency anemia?
|
TIBC is decreased in anemia of chronic disease and elevated in iron deficiency
|
|
MOA of osteltamivir and zanamivir
|
Neuraminidase inhibitors (latter is only for treatment, not prevention, of influenza)
|
|
When should antivirals be administered in influenza pts?
|
Within 48 hrs, otherwise not effective
|
|
TPN pt w/ alopecia, abnormal taste, bullous lesions around orifices, impaired wound healing
|
Zinc deficiency
|
|
Rx for gallstone pt who isn't a surgical candidate (2)?
|
Avoidance of fatty foods
Ursodeoxycholic acid (bile salt that decreases cholesterol content of bile by reducing enterohepatic circulation) |
|
Hypothyroid Sx + carpal tunnel Sx
|
Generalized myxedema --> deposition of acid mucopolysaccharides in skin, heart, and nerves (incl. median nerve)
|
|
Cause of carpal tunnel in pregnancy
|
Accumulation of fluid
|
|
Hematuria, HTN, RBC casts, and mild proteinuria 2 wks after infection and Abx
|
PSGN
|
|
Complement finding in PSGN
|
Low serum C3
|
|
Hematuria 5 days after URI w/ normal complement
|
IgA nepropathy
|
|
Hematuria, peripheral eosinophilia, WBC casts in urine after infection and Abx
|
Drug-induced acute interstitial nephritis
|
|
Diagnostic test for suspected achalasia in pt >60yo or with weight loss
|
Endoscopy to r/o pseudoachalasia (from malignancy)
|
|
Skin condition associated w/ Parkinson's
|
Seborrheic dermatitis
|
|
Electrolyte side effects of loop diuretics
|
Metabolic alkalosis
Hypokalemia Prerenal renal failure |
|
Rx for erythema migrans
|
Is pathognomonic for Lyme disease, so no need to test, just treat with doxycycline
|
|
6 common drugs that cause esophagitis
|
Tetracyclines
Aspirin NSAIDs Alendronate Potassium Iron |
|
Rx for pancreatic pseudocyst
|
Usually just watch; drain only if last >6wks, are >5cm, or become secondarily infected
|
|
Rx for hyperkalemia (5)
|
IV calcium gluconate (to stabilize cardiac membrane)
Shift potassium intracellularly w/ insulin, glucose, sodium bicarb, and beta-2 agonists (albuterol) |
|
Asymmetric breath sounds immediately after intubation
|
Have likely intubated right mainstem bronchus: pull back
|
|
Intermittent flank pain, hematuria, recurrent UTIs/nephrolithiasis, and palpable mass
|
Autosomal dominant polycystic kidney disease
|
|
Why is an enlarged right kidney easier to palpate than on the left?
|
Lies lower
|
|
2 most common electrolyte abnormalities in primary adrenal insufficiency
|
Hyponatremia
Hyperkalemia |
|
HBV is associated with what type of nephrotic syndrome?
|
Membranous glomerulonephritis
|
|
COPD pt with worsening symptoms, chest pain, and unilateral decreased breath sounds
|
Secondary pneumothorax
|
|
Cause of secondary pneumothorax in COPD pts?
|
Destruction of alveolar sacs --> formation of alveolar blebs, which can rupture and leak air into pleural space
|
|
Mobitz type I AV block implies dysfunction where and what type of pattern?
|
AV node
PR intervals that grow progressively longer until a beat is dropped |
|
Tachycardia-bradycardia syndrome on EKG might indicate?
|
Sick sinus syndrome (impaired SA node automaticity from fibrosis or SA node arterial disease)
|
|
Common cause of respiratory acidosis
|
Alveolar hypoventilation
|
|
What decreases the risk of febrile transfusion reaction?
|
Leukocyte depletion techniques (e.g. cell washing)
|
|
Cause of edema in a severe COPD pt?
|
Hypoxemia --> pulmonary arterial constriction --> pulmonary HTN, RVH, and right heart failure
|
|
Who requires yearly influenza vaccines?
|
All adults (IM if elderly or comorbid conditions)
|
|
Who needs a Td vs. a TdaP vaccine?
|
All adults need a Td vaccine every 10 yrs
One time TdaP booster for adults >18yo due to waning immunity against pertussis |
|
Overdose w/ dilated pupils, seizures, QRS prolongation, and hypotension
|
TCA overdose
|
|
Rx for severe TCA overdose
|
Sodium bicarb
|
|
Rx for afib w/ RVR in a pt with Wolf Parkinson White
|
Because they have accessory pathway conduction, don't want to block the AV node further (which typical afib drugs do); so instead, convert to sinus rhythm with cardioversion or antiarrhythmics like procainamide
|
|
Common cause of anemia in a pt with a malignant lymphoproliferative disorder
|
Warm autoimmune hemolytic anemia
|
|
Rx for warm autoimmune hemolytic anemia (first and second line)
|
Prednisone (if ineffective, splenectomy)
|
|
Cause of UTI in a pt with alkaline urine and why
|
Proteus (produces urease, which alkalinizes urine)
|
|
Reactivation of TB causes what CT findings
|
Upper lobe cavitary lesions (+/- surrounding alveolar infiltration)
|
|
Chest pain, severe N/V, widened mediastinum, and unilateral pleural effusion w/ high amylase and low pH
|
Esophageal rupture (Boerhaave's syndrome)
|
|
Rx for any chemical contact with eye
|
Run under water for at least 15 min
|
|
Rx for pt with high homocysteine (3) and why
|
Vitamin B6 (pyridoxine) which is a cofactor of cystathionine Beta-synthase (which metabolizes homocysteine into cystathionine
Also, folate and B12 |
|
Rx for hepatic adenoma
|
Resect if symptomatic
Otherwise, can watch with imaging and serial AFP measurements |
|
Concern with hepatic adenoma (2)
|
Hemorrhage
Malignant transformation |
|
Most common asymptomatic isolated elevation of alk phos in the elderly
|
Paget's disease of bone (osteitis deformans)
|