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46 Cards in this Set

  • Front
  • Back
Rb
13q

Retinoblastoma, osteosarcoma
BRCA1
17q

Breast, ovarian
BRCA2
13q

breast
p53
17p

almost all human cancers
p16
9p

Melanoma
APC
5q

FAP (colorectal cancer)
WT1
11p

Wilms tumor
NF1
17q

NF1
NF2
22q

NF2
DPC
18q

pancreatic cancer
DCC
18q

Colon cancer
"Delected in Colon Cancer"
PSA
prostate carcinoma, BPH, prostatitis.
Prostatic acid phosphatase
Prostate carcinoma
CEA
= Carcinoembryonic antigen

~70% of CRC and pancreatic cancers, also produced by gastric and breast carcinomas.
a-FP
hepatocellular carcinoma, nonseminomatous germ cell tumors of the testes.
B-hCG
hydatidiform mole, choriocarcinoma, and Gestational trophoblastic tumors.
CA-125
Ovarian, malignant epithelial tumors
S-100
Melanoma, neural tumors, astrocytomas
Alk phos
mets to bone, obstructive biliary dz, paget's dz of bone.
Bombesin
Neuroblastoma, lung, and gastric cancer.
TRAP
"TRAP the hairy animal"

Hairy cell leukemia (B-cell neoplasm)
CA-19-9
Pancreatic adenocarcinoma.
c-kitt
oncogene

Gastrointestinal stromal tumor
ret
oncogene

MEN II and III (IIa and IIb)
N-myc
oncogene

neuroblastoma
L-myc
oncogene

Lung neoplasm
ras
oncogene

colon carcinoma
erb-B2
oncogene

breast, ovarian, and gastric carcinomas
bcl-2
Follicular and undifferentiated lumphomas (it inhibits apoptosis)
c-myc
Burkitt's lymphoma
abl
oncogene

CML (9;22)
Vinyl choloride causes what?
liver angiosarcoma
Smoking?
SSC of the esophagus, lung SSC and small cell, kidney renal cell carcinoma, and bladder (transitional cell carcinoma)
Naphthalene (aniline dye) causes what type of cancer in which organ?
Bladder (transitional cell carcinoma)
Two lung cancers cause by asbestos?
mesothelioma and bronchogenic carcinoma.
Causes of paraneoplastic ACTH?
small cell lung
Causes of paraneoplastic ADH?
small cell lung, intracranial neoplasms
Causes of paraneoplastic PTH, TGF-B, TNF, IL-1?
SSC lung, renal cell carcinoma, and breast carcinoma.
Causes of paraneoplastic EPO?
renal cell carcinoma, hemangioblastoma.
Causes of paraneoplastic antibodies against presynaptic Ca channels at NMJ?

- causes what?
Thymoma, Small cell lung

Lambert-Eaton Syndrome (muscle weakness)... gets better w/exercise.
Causes of paraneoplastic Hyperuricemia due to excess nucleic acid turnover?
Leukemias, and lymphomas.
4 Places Psmomma bodies are seen?
Papillary adenocarcinoma of thyroid; serous papillary cystadenocarcinoma of ovary; Meningioma; Malignant mesothelioma.

PSaMMoma.
Primary tumors that met to brain?
Lots of Bad Stuff Kills Glia

Lung, Breast, Skin (melanoma), Kidney (renal cell carcinoma), GI
Primary tumors that met to liver?
Cancer Sometimes Penetrates Benign Liver

Colon> Stomach > Pancreas > Breast > Lung
Most common sites for mets to go (besides regional lymph nodes)?
liver and lung
Primary tumors that met to bone?
- two most common?
- lytic or blastic?
PT Barnum Loves Kids

Prostate, Thyroid, Breast, Lung (lytic), Kidney

Breast (lytic AND blastic) and Prostate (blastic)