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46 Cards in this Set
- Front
- Back
Rb
|
13q
Retinoblastoma, osteosarcoma |
|
BRCA1
|
17q
Breast, ovarian |
|
BRCA2
|
13q
breast |
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p53
|
17p
almost all human cancers |
|
p16
|
9p
Melanoma |
|
APC
|
5q
FAP (colorectal cancer) |
|
WT1
|
11p
Wilms tumor |
|
NF1
|
17q
NF1 |
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NF2
|
22q
NF2 |
|
DPC
|
18q
pancreatic cancer |
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DCC
|
18q
Colon cancer "Delected in Colon Cancer" |
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PSA
|
prostate carcinoma, BPH, prostatitis.
|
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Prostatic acid phosphatase
|
Prostate carcinoma
|
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CEA
|
= Carcinoembryonic antigen
~70% of CRC and pancreatic cancers, also produced by gastric and breast carcinomas. |
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a-FP
|
hepatocellular carcinoma, nonseminomatous germ cell tumors of the testes.
|
|
B-hCG
|
hydatidiform mole, choriocarcinoma, and Gestational trophoblastic tumors.
|
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CA-125
|
Ovarian, malignant epithelial tumors
|
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S-100
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Melanoma, neural tumors, astrocytomas
|
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Alk phos
|
mets to bone, obstructive biliary dz, paget's dz of bone.
|
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Bombesin
|
Neuroblastoma, lung, and gastric cancer.
|
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TRAP
|
"TRAP the hairy animal"
Hairy cell leukemia (B-cell neoplasm) |
|
CA-19-9
|
Pancreatic adenocarcinoma.
|
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c-kitt
|
oncogene
Gastrointestinal stromal tumor |
|
ret
|
oncogene
MEN II and III (IIa and IIb) |
|
N-myc
|
oncogene
neuroblastoma |
|
L-myc
|
oncogene
Lung neoplasm |
|
ras
|
oncogene
colon carcinoma |
|
erb-B2
|
oncogene
breast, ovarian, and gastric carcinomas |
|
bcl-2
|
Follicular and undifferentiated lumphomas (it inhibits apoptosis)
|
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c-myc
|
Burkitt's lymphoma
|
|
abl
|
oncogene
CML (9;22) |
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Vinyl choloride causes what?
|
liver angiosarcoma
|
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Smoking?
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SSC of the esophagus, lung SSC and small cell, kidney renal cell carcinoma, and bladder (transitional cell carcinoma)
|
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Naphthalene (aniline dye) causes what type of cancer in which organ?
|
Bladder (transitional cell carcinoma)
|
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Two lung cancers cause by asbestos?
|
mesothelioma and bronchogenic carcinoma.
|
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Causes of paraneoplastic ACTH?
|
small cell lung
|
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Causes of paraneoplastic ADH?
|
small cell lung, intracranial neoplasms
|
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Causes of paraneoplastic PTH, TGF-B, TNF, IL-1?
|
SSC lung, renal cell carcinoma, and breast carcinoma.
|
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Causes of paraneoplastic EPO?
|
renal cell carcinoma, hemangioblastoma.
|
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Causes of paraneoplastic antibodies against presynaptic Ca channels at NMJ?
- causes what? |
Thymoma, Small cell lung
Lambert-Eaton Syndrome (muscle weakness)... gets better w/exercise. |
|
Causes of paraneoplastic Hyperuricemia due to excess nucleic acid turnover?
|
Leukemias, and lymphomas.
|
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4 Places Psmomma bodies are seen?
|
Papillary adenocarcinoma of thyroid; serous papillary cystadenocarcinoma of ovary; Meningioma; Malignant mesothelioma.
PSaMMoma. |
|
Primary tumors that met to brain?
|
Lots of Bad Stuff Kills Glia
Lung, Breast, Skin (melanoma), Kidney (renal cell carcinoma), GI |
|
Primary tumors that met to liver?
|
Cancer Sometimes Penetrates Benign Liver
Colon> Stomach > Pancreas > Breast > Lung |
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Most common sites for mets to go (besides regional lymph nodes)?
|
liver and lung
|
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Primary tumors that met to bone?
- two most common? - lytic or blastic? |
PT Barnum Loves Kids
Prostate, Thyroid, Breast, Lung (lytic), Kidney Breast (lytic AND blastic) and Prostate (blastic) |