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14 Cards in this Set
- Front
- Back
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Typical Antipsychotics
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haldol + 'azines' (trifluoperazine, fluphenazine, chlorpromazine, thiordizine)
Mech: block D2 receptor Use: schizophrenia, tourettes, pyschosis/acute mania Side effects 1) extrapyramidal a) acute dystonic reaction, b) akinesia, c) akathisia (restlessness), d (tardive dyskinesia) 4 hours, 4 days, 4 weeks, 4 months Neuroleptic malignant syndrome - fever, encephalopathy, vitals unstable, elevated enzymes, rigidity of muscles (myglobinuria). treat with dantrolene 3) endocrine side effects - hyperprolactinemia 4) blocking muscarinics (dry mouth/constipation), alphas (hypotension), histamine (sedation) |
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high potency typical antipsychotics
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haldol, trifluoperazine, fluphenazine (so not thio or chlorinated)
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atypical antipsychotics
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clozapine, olanzapine, risperidone, aripiprazole, quietipaine, ziprasidone
(not atypical for old closets risper quietly at zippers.) Mechanism: Block 5HT2, alpha, Histamine, and dopamine receptors use: schizophrenia, bpolar. olanzapine for OCD and others Toxicity - weight gain (esp olanzapine). clozapine maybe agrunulocytosis |
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lithium
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Mechanism: unknown
use: bipolar toxicity: LMNOP. movement (tremor), nephrogenic diabetes insipidus, hypothyroid, pregnancy) |
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buspirone
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mech: stimulates 5-HT1a receptor
use: GAD. no sedation or addiction. no interaction with alcohol. |
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tricyclics
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pramines + amitriptyline
mech: block NE and seratonin uptake use: major depression, bedwetting (imipramine), OCD (clomipramine) side effects - alpha blocking (orthostatic), anticholinergics (tachycardia, urinary retention). tertiarys (amitryptaline) worse than secondarys Toxicity: delirium, arrhythmias (bicarb), cholinergic |
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SSRI
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Fluoxetine, paroxetine, sertraline, citalopram
Use: OCD, depression Toxicity: serotonin syndrome, sexual dysfunction, GI |
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MAOI
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Phenelzene, tranylcypromine
Mech- inhibiti MAO - raising amine transmitter levels use: atypical depression, anxiety, hypochondriasis toxicity - tyramine ingestion leading to hypertensive crisis. SSRI or meperidine can lead to seratonin syndrome |
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Bupropion
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increases NE, dopamine by unknown mechanism
Use: smoking, depression Toxicity: stimulant effects (tachycardia, insomnia), seizure in bulimic patients ! (electrolyte abnormalities) |
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Venlafaxine
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Inhibits norepi, seratonin
use: depression toxicity: higher BP, stimulant effects, sedation/nausea |
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Duloxetine
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inhibits seratonin, norepinephrine. more NE than venlafaxine
Use: depression, diabetic peripheral neuropathy toxicity: same as venlafaxine |
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Mirtazapine
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alpha 2 antagonist (which raises release of NE and serotonin), so opposite of alphamethyl dopa/clonidine
also potent 5HT2, 5HT3 antagonist use: antidepressent side effects: sedation (use for insomnia though), appetite and weight gain |
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Maprotiline
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NE reuptake inhibitor
use: depression toxicity: sedation, orthostasis |
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Trazodone
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Mech: inhibit serotonin reuptake.
used for insomnia. side effects: priapism, sedation |
