Step 1 - Pharm - Side Effects

Front 1

Atropine-like side effects that affect the CV system (1)

Back 1

Tricyclic antidepressants

Front 2

Coronary vasospasm (2)

Back 2

Cocaine (catecholamine reuptake inhibitor)
Sumatriptan (5-HT agonist)

Front 3

Cutaneous flushing (4)

Back 3

Niacin
Ca channel blockers
Adenosine
Vancomycin

Front 4

Dilated cardiomyopathy (2)

Back 4

Doxorubicin (adriamycin), daunorubicin

(intercalators, vs. alkylators)

Front 5

Torsades de points (3)

Back 5

Class IA (quinidine) and class III (sotalol) antiarrhythmics
Cisapride (prokinetic; rx:GERD)

Front 6

Agranulocytosis (5)

Back 6

Clozapine
Carbamazepine
Colchicine
Propylthiouracil
Methimazole

Front 7

Aplastic anemia (5)

Back 7

Chloramphenicol, benzenes, NSAIDs, propylthiouracil, methimazole

Front 8

Direct Coombs-positive hemolytic anemia (1)

Back 8

Methyldopa.

Direct implies that the antibodies are on the patient's red blood cells

Front 9

Gray baby syndrome (1)

Back 9

Chloramphenicol (babies lack liver UDP-glucuronyl transferase)

Front 10

Hemolysis in G6PD-deficiency patients (6)

Back 10

Isoniazid, sulfonamides, primaquine, aspirin, ibuprofen, nitrofurantoin, dapsone
("hemolysis I.S. P.A.I.N." + dapsone)

These are "oxidant" drugs

Front 11

Megaloblastic anemia (3)

Back 11

Phenytoin, Methotrexate, Sulfa drugs ("having a megablast with P.M.S.")

Front 12

Thrombotic complications (1)

Back 12

OCPs (estrogens, progestins)

Front 13

Cough (1)

Back 13

ACE inhibitors

Front 14

Pulmonary fibrosis (3)

Back 14

Bleomycin, busulfan, amiodarone

Front 15

Acute cholestatic hepatitis (1)

Back 15

Macrolides (erythromycin, azithromycin, clarithromycin)

Front 16

Focal to massive hepatic necrosis (4)

Back 16

Halothane, valproic acid, acetaminophen, Amanita phalloides (death cap fungus)

Front 17

Hepatitis (1)

Back 17

Isoniazid (INH)

Front 18

Pseudomembranous colitis (2)

Back 18

Clindamycin, ampicillin

[Due to killing off of commensurals and allowing C. difficile to proliferate]

Front 19

Adrenocortical insufficiency (1)

Back 19

Glucocorticoid withdrawal (HPA suppression)

Front 20

Gynecomastia (6)

Back 20

Spironolactone, digitalis, cimetidine, chronic alcohol use, ketoconazole, estrogen ("Some Drugs Create Awesome Knockers")

Front 21

Hot flashes (2)

Back 21

Tamoxifen, clomiphene

Front 22

Gingival hyperplasia (1)

Back 22

Phenytoin

Front 23

Gout (2)

Back 23

Furosemide, heparin

("...F,G,H...")

Front 24

Osteoporosis (2)

Back 24

Corticosteroids, heparin

Front 25

Photosensitivity (3)

Back 25

Sulfonamides, amiodarone, tetracycline ("S.A.T. for a photo")

Front 26

Stevens-Johnson Syndrome (rash) [8]

Back 26

Ethosuximide
Lamotrigine
Carbamazepine
Phenobarbital
Phenytoin
Sulfa drugs
Penicillin
Allopurinol

Front 27

SLE-like syndrome (4)

Back 27

Hydralazine, isoniazid, procainamide, phenytoin ("it's not H.I.P.P. to have lupus")

Front 28

Tendonitis, tendon rupture, cartilage damage in kids (1)

Back 28

Fluoroquinolones
(Cipro-, nor-, moxi-, gati-, spar-, ofloxacin; enoxacin)

Front 29

Proximal tubular function of the kidney is impaired, resulting in decreased reabsorption of electrolytes and nutrients back into the bloodstream. Compounds involved include glucose, amino acids, uric acid, phosphate and bicarbonate. The reduced reabsorption of bicarbonate results in Type 2 or proximal renal tubular acidosis. (1)

Back 29

Expired tetracyclines (Fanconi's syndrome)

Front 30

Interstitial nephritis (3)

Back 30

Methicillin, NSAIDs, furosemide

Front 31

Hemorrhagic cystitis (2)

Back 31

Cyclophosphamide, ifosfamide

Front 32

This side effect caused by these drugs is prevented by coadministering mesna

Back 32

Hemorrhagic cystitis caused by cyclophosphamide and ifosfamide

Front 33

What are the signs and symptoms of cinchonism?

Back 33

Flushed and sweaty skin, tinnitus, blurred vision, impaired hearing, confusion, abdominal pain, rashes, lichenoid photosensitivity, vertigo, dizziness, dysphoria, nausea and vomiting, and diarrhea. In higher doses, anaphylactic shock, and disturbances in cardiac rhythm or conduction, death from cardiotoxicity.

Front 34

Cinchonism (2)

Back 34

Quinidine, quinine

Front 35

Diabetes insipidus (2)

Back 35

Lithium, demeclocycline

Front 36

Parkinson-like syndrome (4)

Back 36

Haloperidol, chlorpromazine, reserpine (antipsychotics); metoclopramide (antiemetic)

Front 37

Seizures (3)

Back 37

Imipenem (cilastatin), buproprion, isoniazid

Front 38

Tardive dyskinesia (1)

Back 38

Antipsychotics

Front 39

Disulfram-like reaction (4)

Back 39

Metronidazole, some cephalosporins, procarbazine (DNA alkylator; antineoplastic), 1st-generation sulfonylureas
(meaning that they inhibit the breakdown of EtOH by inhibiting aldehyde dehydrogenase)

Front 40

Nephrotoxicity and neurotoxicity (1)

Back 40

Polymyxins

Front 41

Nephrotoxicity and ototoxicity (4)

Back 41

Aminoglycosides, vancomycin, loop diuretics, cisplatin

(Aminoglycosides include gentamicin, neomycin, amikacin, tobramycin, streptomycin)

Front 42

Inducers of CYP450 (7)

Back 42

Quinidine, barbiturates, St John's wort, phenytoin, rifampin, griseofulvin, carbamazepine

"Queen Barb Steals Phen-phen and Refuses Greasy Carbs"

Front 43

Inhibitors of CYP450

Back 43

Sulfonamides, isoniazid, cimetidine, ketoconazole, erythromycin, grapefruit

"Inhibit yourself from drinking from a K.E.G. because it makes you S.I.C."

Front 44

Aplastic anemia (2)

Back 44

Chloramphenicol, alkylating agents

Front 45

Hemolytic anemia (3)

Back 45

Penicillin, methyldopa, quinidine

Front 46

Macrocytic anemia (4)

Back 46

Methotrexate (MCC), phenytoin, OCPs, 5-FU

Front 47

Tinnitus, vertigo (1)

Back 47

Salicylates

Front 48

Hemorrhagic gastritis (2)

Back 48

Iron, salicylates

Front 49

Cholestasis (3)

Back 49

OCPs, estrogens, anabolic steroids

Front 50

Fatty liver change (3)

Back 50

Amiodarone, tetracycline, methotrexate

Front 51

Hepatic ademona (1)

Back 51

OCPs

Front 52

Liver necrosis (5)

Back 52

Acetaminophen, salicylates, isoniazid, halothane, iron

Front 53

Interstitial fibrosis (4)

Back 53

Bleomycin, busulfan, nitrofurantoin (antibiotic for UTI), methotrexate, amiodarone

Front 54

Drug-induced lupus (2)

Back 54

Procainamide, hydralazine (reduces release of Ca from SR in smooth muscle cells, thus vasodilates; used to treat HTN)