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11 Cards in this Set
- Front
- Back
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repeat in huntington's. neuronal death due to... area of brain affected...
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CAGon chromo 4. due to NMDA-R binding and glu toxicity. Caudate affected so loss of ACh and GABA
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TTP symptoms and etiology...
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FAT RN- Fever, hemolytic anemia, Thrombocytopenia, Renal issues, Neuro issues. shistocytes, LDH incr. Due to lack of vWF protease
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ITP etiology...
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antibodies to platelets (anti-GpIIb/IIIa) causing peripheral platlet destrxn.
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bernard-soulier dx... labs...
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defect in platlet plug formation due to decr Gp1b--> poor platlet-collagen adhesion. decr platlet count and incr bleeding time
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Glanzmann's thromboastheia etiology... labs...
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decr GpIIb/IIIa--> poor platlet-platlet adhesion. Labs show NORMAL platlet count but incr bleeding time
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RNA processing in nucleus 3 steps...
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capping on 5' w/ 5-methylG, polyadenylation, splicing
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splicing done by... proteins. method... disease that affects
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done in nucleus by snRNPs. make a lariat (loop) and cut out. Lupus affects the Loops so doesn't work as well
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enzyme most responsible for accuracy of AA selection in protein syn and it's funxn
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aminoacyl-tRNA syn. binds AA to 3' end of tRNA and proofreads it. 1 AA per aminoacyl-tRNA syn
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fnxn of eIFs in protein syn... when signaled to leave...
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eIF assemble 40s subunit w/ initiator tRNA. Released when mRNA assembles w/ subunit.
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3 sites in ribosome and funxn of each in protein syn...
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A: incoming Aminoacyl-tRNA binds and receives growing peptide. P: aminoacyl-tRNA--peptide complex moved here (translocation). E: holds Empty tRNA as it Exits
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use of ATP in protein syn... use of GTP in protein syn...
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ATP- used for tRNA charging w/ AA. GTP for protein initiation and translocation in ribosome
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