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7 Cards in this Set
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cyclosporine
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mechanism: blocks differentiation and activation of T cells by inhibiting calcineurin
Use: organ rejection, autoimmune disorders toxicity: viral infections, lymphomas, nephrotoxic (give mannitol to induce diuresis) |
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tacrolimus (FK506)
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similar to cyclosporin (calcineurin inhibitor) but via FK binding proteins
use: immunosuppressant in transplants toxicity: significant: nephrotoxic, neuropathy, pleural effusion, dia/htn |
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azathioprine
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mechanism: inhibits PRPP something, prevents purine synthesis; it's a precursor of 6-MP, so same thing
use: kidney transplant, autoimmune toxicity: interacts with allopurinol (degraded by XO, so allo raises levels). bone marrow suppression |
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muromonab-CD3 (OKT3)
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mechanism: monoclonal antibody, binds CD3 (epsilon chain)
blocks CD3 interaction with other cells, inhibiting activation use: immunesuppresion right after transplant toxicity: cytokine release syndrome, hypersensitivity |
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sirolimus (rapamycin)
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Mechanism: binds to mTOR (target of rapomycin); inhibits T cell proliferationin response to IL-2
Use: immunesuppression in adjunct w/ cyclosporin, steroids toxicity: hyperlipidemia, thrombocytopenia, leukopenia |
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mycophenolate mofetil
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mechanism: blocks de-novo guanine synthesis
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daclizumab
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MAB for IL-2 receptor on active T cells
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