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16 Cards in this Set
- Front
- Back
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Toxicity of Quinidine
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ELONGATION of QT interval ---> TORSADES de POINTs.
HA, tinnitus, thrombocytopenia. |
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Class of Quinidine?
- effects? - used in what? |
Class IA.
^^AP duration, ^^effective refractory period. GOOD for reducing firing rate (trophism for highly active tiss) . Affect both atrial and ventricular arrhythmias. reentrant and ectopic superventricular and ventricular tachycardia. |
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What are 3 class I's?
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Procainamide, Disopyramide, Quinidine
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Toxicity of Procainamide?
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reversible SLE-like syndrome
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Prototypical Class IB antiarrhythmic?
- two other examples? |
Lidocaine.
- Mexiletine, Tocainide "Lidy's Mexican Tacos cause ischemia" |
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What type of tissue to IB's preferentially affect?
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Ischemic or depolarized Purkinje and ventricular tissue.
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What drugs are especially useful in actute ventricular arrhtymia's, especially post MI? Why?
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Class IB - preferentially affect depolarized or ischemic tissue in Purkinje and ventricular areas.
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what class does Phenytoin get into of the class I drugs?
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IB.
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What drugs are especially good in digitalis-induced arrhythmias? Why?
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Class IB
Digoxin and the other cardiac glycosides induce their arrhythmias by preventing Na/K ATPase channels from repolarizing the cell. |
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Give me the effect the following classes have on AP duration:
IA, IB, IC |
IA increases, IB decreases, IC no change.
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Which antiarrhtymics are useful in V-cach that progress to VF, and also in intractable SVT?
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Class IC.
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Should IC drugs be used in refractory tacharrhythmias?
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only as a LAST resort.
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What type of drug is Flecainide?
two others? |
Class IC
Chipotle's Food has Excellent Produce. Flecainide, Encainide, Propafenone |
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Which class I drugs are good post MI? Bad?
Why? |
Class IB: Lidocaine, Mexiletine, Tocainide
Class IC: Flecainide Encainide, Propafenone Class IC drugs are proarrthmic, especially post MI. |
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What is the class IC mechanism?
- major potential tox? |
significantly prolongs refractory period in AV node.
- can be proarrhythmic. |
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Hyperkalemia does what to toxicity of all Class I antiarrhythmics?
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INCREASES toxicity.
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