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34 Cards in this Set
- Front
- Back
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3D Bioplotter
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a 3D Dispenser and allows to process a magnitude of materials including various biochemical systems and even living cells
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Achieving nutrient transfer in tissue construct 4 methods.
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1.) Simple diffusion in static culture
2.) suspended in moving culture 3.) forcing the nutrients perfuse through construct 4.) designing channels in construct like blood vessels. |
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growing an organ, steps (4)? challenges?
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1.) pick a stem cell
2.) get them to grow/divide 3.)simulate the environment 4.)make organ challenges- oxygen nutrients, scaffolding for growth |
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challenge of making nerves
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forcing them to grow in certain direction
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olympic ring material
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photoresist plastic, silicone, polystyrene
fibronectin, meningeal fibroblasts, nerve cells |
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earliest regenerative techniques
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growing cells on bioscaffold
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3 types of regeneration
2 Advances |
cell-based tissue regeneration- apply cells to damaged site
scaffold-guided tissue regeneration- seeding porous scaffold and culturing bioactive molecule-based tissue regeneration- regulatory growth factors to induce direct cell growth and differentiation regenerate tissue in vivo, tissues in vitro |
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cell-based regeneration challenges (3)
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directing cells to proper place, integrating cells with the patients tissue, overcoming tissue rejection
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scaffold regeneration challenges (4)
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cell integration in scaffold, efficiency, cell-scaffold interactions, lifetime,
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growth factor for bone precursor cells
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BMP-2
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Autograft and problems
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taking tissue from one location in patients body and relocating. no rejection.
Problems: need good harvest site, more costly, more pain |
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Allografting
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tissues and organs from a donor transplanted into patient.
Problems: donor shortages, disease transmission, rejection +medication |
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Regenerative medicine options
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autografts, xenograft- tissue from animals, man made devices....all with problems
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Hattler Catheter
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first commercial artificial lung
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Stroke treatment
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stem cells on scaffold plug hole in 7 days
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Amniotic and placental stem cells
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properties of both embryonic and adult stem cells. treatment for diabetes, liver, heart
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electrospinning
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make scaffolds for blood vessels, muscles and tendons. biomaterial in solvent and apply high voltage to the solution as its ejected from the syringe, charge- attracted to collection mandrel
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InkJet technology
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cells go in cartriges and are printed in specific order to makes tissues and organs
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ideal biomaterial for scaffold
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compatible with body, promotes cell growth, degrades in the body as the engineered tissue integrates with existing tissue
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Precision XS robotic system
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96 samples in less than 14 seconds to see compatability of biomaterials
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high powered microscopes for tissue engineering
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detect size, shape, and activity of engineered cells
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organ bath
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experimental set up to test lab-engineered tissue. study how tissues respond to chemical agents, electrical impulses.
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most prevalent protein in human body
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collagen
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sequential wound healing activities (4)
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1.) hemostasis
2.) reaction-inflamation stage (infection control) 3.) regeneration (fill wound) 4.) remodeling stage- tissue strengthened. |
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collagens role in wound (4)
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1.) Guiding function
2.) Chemotactic properties 3.)Nucleation 4.)Hemostatic Properties |
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Things that could prevent proper wound healing (3)
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1.) improper moisture content
2.)inadequate delivery of oxygen 3.) infection 4.) disorders/nutrition/vascular insufficiency |
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human biosciences
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bovine collagen helps healing -triple helical structure
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bone strength and collagen
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Collagen 1 combines with hydroxyapatite for bone strength and resistance
lack fo collagen = osteogenesis imperfecta |
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skin resilience and collagen
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papillary dermis- collagen 3 makes skin pliable
reticulate dermis- collagen 1 gives skin tensile strength lack of = wrinkles and thin dermis |
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muscles and collagen
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endomysium- innermost collagen sheath
perimysium- middle epimysium- outer helps contract and stretch |
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tendons, ligaments, cartilage and collagen
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type 2 collagen in cartilage, reduce friction between joint and keeps shape of structures, collagen in tendons and ligaments assists movement
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wound healing and collagen
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dermis of skin has collagen to repair wound. too much- loss of shape. too little- not healed
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scanning electron microscope
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surface area of scaffold
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confocal laser scanning microscope
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3d image
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