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34 Cards in this Set

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3D Bioplotter
a 3D Dispenser and allows to process a magnitude of materials including various biochemical systems and even living cells
Achieving nutrient transfer in tissue construct 4 methods.
1.) Simple diffusion in static culture
2.) suspended in moving culture
3.) forcing the nutrients perfuse through construct
4.) designing channels in construct like blood vessels.
growing an organ, steps (4)? challenges?
1.) pick a stem cell
2.) get them to grow/divide
3.)simulate the environment
4.)make organ
challenges- oxygen nutrients, scaffolding for growth
challenge of making nerves
forcing them to grow in certain direction
olympic ring material
photoresist plastic, silicone, polystyrene
fibronectin, meningeal fibroblasts, nerve cells
earliest regenerative techniques
growing cells on bioscaffold
3 types of regeneration

2 Advances
cell-based tissue regeneration- apply cells to damaged site
scaffold-guided tissue regeneration- seeding porous scaffold and culturing
bioactive molecule-based tissue regeneration- regulatory growth factors to induce direct cell growth and differentiation

regenerate tissue in vivo, tissues in vitro
cell-based regeneration challenges (3)
directing cells to proper place, integrating cells with the patients tissue, overcoming tissue rejection
scaffold regeneration challenges (4)
cell integration in scaffold, efficiency, cell-scaffold interactions, lifetime,
growth factor for bone precursor cells
BMP-2
Autograft and problems
taking tissue from one location in patients body and relocating. no rejection.

Problems: need good harvest site, more costly, more pain
Allografting
tissues and organs from a donor transplanted into patient.

Problems: donor shortages, disease transmission, rejection +medication
Regenerative medicine options
autografts, xenograft- tissue from animals, man made devices....all with problems
Hattler Catheter
first commercial artificial lung
Stroke treatment
stem cells on scaffold plug hole in 7 days
Amniotic and placental stem cells
properties of both embryonic and adult stem cells. treatment for diabetes, liver, heart
electrospinning
make scaffolds for blood vessels, muscles and tendons. biomaterial in solvent and apply high voltage to the solution as its ejected from the syringe, charge- attracted to collection mandrel
InkJet technology
cells go in cartriges and are printed in specific order to makes tissues and organs
ideal biomaterial for scaffold
compatible with body, promotes cell growth, degrades in the body as the engineered tissue integrates with existing tissue
Precision XS robotic system
96 samples in less than 14 seconds to see compatability of biomaterials
high powered microscopes for tissue engineering
detect size, shape, and activity of engineered cells
organ bath
experimental set up to test lab-engineered tissue. study how tissues respond to chemical agents, electrical impulses.
most prevalent protein in human body
collagen
sequential wound healing activities (4)
1.) hemostasis
2.) reaction-inflamation stage (infection control)
3.) regeneration (fill wound)
4.) remodeling stage- tissue strengthened.
collagens role in wound (4)
1.) Guiding function
2.) Chemotactic properties
3.)Nucleation
4.)Hemostatic Properties
Things that could prevent proper wound healing (3)
1.) improper moisture content
2.)inadequate delivery of oxygen
3.) infection
4.) disorders/nutrition/vascular insufficiency
human biosciences
bovine collagen helps healing -triple helical structure
bone strength and collagen
Collagen 1 combines with hydroxyapatite for bone strength and resistance

lack fo collagen = osteogenesis imperfecta
skin resilience and collagen
papillary dermis- collagen 3 makes skin pliable
reticulate dermis- collagen 1 gives skin tensile strength

lack of = wrinkles and thin dermis
muscles and collagen
endomysium- innermost collagen sheath
perimysium- middle
epimysium- outer
helps contract and stretch
tendons, ligaments, cartilage and collagen
type 2 collagen in cartilage, reduce friction between joint and keeps shape of structures, collagen in tendons and ligaments assists movement
wound healing and collagen
dermis of skin has collagen to repair wound. too much- loss of shape. too little- not healed
scanning electron microscope
surface area of scaffold
confocal laser scanning microscope
3d image