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4 Cards in this Set
- Front
- Back
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What are the 3 types of hematopoietic transplants?
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Bone marrow, peripheral blood, cord blood
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What are the major challenges that must be overcome for successful stem cell therapy?
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Seed Threshold: quantity of viable stem cells must be large enough or the transplant will fail.
Cell Culture Expansion: need to prevent differentiation of the stem cells when expanding them in culture so they remain useful. Immunogenic rejection Development of a secondary cancer: since stem cells are rapidly dividing. Infection from a contaminated transplant |
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What is one way cell differentiation is controlled when growing stem cells in culture in preparation for transplant?
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Growth factors
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How can immunogenic rejection chances be minimized?
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use autologous cells (cord cells!)
histocompatability matching if need to use an external donor |
