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7 Cards in this Set
- Front
- Back
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inflammatory response |
initial response (1-10 days) |
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vascular response |
initial contraction (vasoconstriction) to decrease blood flow for 5-10 min. following platelet aggregation, vessels vasodialate to increase blood flow to the area |
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cellular response |
platelets aggregrate and fibrin is deposited to form a clot |
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chemical mediators of inflammation |
leukocytes infiltrate the area. macrophage cells attract fibroblasts into the area |
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proliferative phase |
second stage (3-21 days)- capillary buds and granulation tissue begin to fill the wound to support epithelial cell migration. keratinocytes, endothelial cells, and fibroblasts are active. |
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remodeling phase |
(7 days - 2 years)- granulation and epithelial differentiation appear in the wound bed. fiber reorganization and contraction shrink and thin the scar. newly repaired scar tissue is remodeled with 15% of tensile integrity. as it matures it gets 80% of pre injury strength |
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factors affecting tissue repair |
age comorbidities edema inappropriate wound care infection lifestyle medication obesity |
