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9 Cards in this Set

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What is the difference between addiction and physical dependance?
Addiction is a mental disorder, i.e. a psychological dependance. A person can be addicted to a variety of things. A physical dependance starts when tolerance (cell changes) begins. Often occur independantly from one another.
What are the three major characteristics of addiction?
compulsive
much time invested (thinking, doing, getting $)
high rate of relapse
Describe a typical withdrawal reaction.
Opposite effects to that of drug. Range in severity depending upon:
amount used/day
length of use
time of withdrawal
With regards to teratogenicity, define "selectivity".
They interfere with fetal development at doses that do not damage the placenta or maternal function.
Name two drugs commonly found to cause birth defects:
Accutane
Thalidomide > Phecomelia
When is the fetus most sensitive to teratogens?
3rd week to the 3rd month. Before this = spontaneous abortions, after this = organogenesis complete.
A single teratogen can produce _____ defects, while many teratogens can produce ______ defects.
one can produce many defects while many can produce the same one.
e.g. rubella > several malformations
Do animal studies accurately predict human teratogenicity?
No, animal studies are not useful.
What do FDA Teratogenic categories A,B,C,D,X stand for?
A> no fetal risk
B> starts to show in animal studies
C> some fetal risk
D> risk shown in humans
X> risk clearly shown