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14 Cards in this Set
- Front
- Back
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Name 4 types of seronegative spondyloarthropathies (SpAs)
Why is it called seronegative? |
4 types:
1. Ankylosing Spondylitis (AS) 2. Reactive arthritis or Reiter's syndrome 3. Psoriatic arthritis 4. Enteric arthritis or Inflammatory bowel spondylitis/sacroilitis They are called seronegative because there is no associated specific autoantibody. |
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What are common features of SpAs? (6)
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1. no specific autoantibody
2. Increased frequency of HLA-B27 3. Absence of rheumatoid factor 4. involvement of SI and spinal joints 5. Enthesopathy or Enthesitis - inflammation of enthuses (sites where tendons and ligaments insert into bone) 6. common mucotaneous lesions |
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What is enthesopathy?
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lesion or calcification at ligamentous attachments to bone
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Compare and contrast syndesmophytes with osteophytes.
Which one is associated with alkylosing spondylitis? |
Syndemophytes - ossification along vertebral ligaments (annulus fibrosis and spinal longituidinal ligaments) and parallel to spine; associated with alkylosing spondylitis
Osteophytes - directed laterally in the horizontal plane; associated with osteoarthris |
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Acute anterior uveitis is associated with which SpA?
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Alkylosing spondylitis (AS)
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What is keratoderma blenorrhagica?
Which SpA is associated with this? |
Scaling, papulo- to postular lesions on soles of feet.
Associated with Reiter's syndrome |
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Name an microorganism that is associated with ReA and causes GU infections.
Name 4 enteric bacteria that are associated with enteritis-associated ReA. |
Chlamydia trachomatis - associated with ReA and GU infections.
4 Enteric bacteria 1. Salmonella 2. Shigella 3. Yersinia 4. Campylobacteria |
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Which SpA is associated with sausage digits, esp at DIPs of fingers?
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Psoriatic arthritis
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Name 2 inflammatory bowel diseases that are associated with enteropathic arthritis (or Inflammatory bowel spodylitis/sacroilitis).
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1. Crohn's disease
2. Ulcerative colitis |
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How are SpAs treated? (i.e. list treatments in least to most aggresive order)
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Least to most aggressive (1-5)
1. Rest, physical therapy 2. NSAIDs, muscle relaxants 3. antimetabolites, such as methotrexate 4. corticosteroids 5. other immunosuppresive therapies. |
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Identify the type of SpA.
Symptoms: Enthesopathy syndesmophytes symmetrical sacroiltis Acute Uveitis. |
Ankylosing spondylitis
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Identify the type of SpA.
Symptoms: Urethritis/cervicitis bilateral conjunctivitis Circinate balanitis Keratoderma blenorrhgica Enthesopathy Mild sacroilitis |
Reiter's syndrome or Reactive arthritis
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Identify the type of SpA.
Symptoms: Sausage digits on DIPs Asymmetrical joint involvement |
Psoriatic arthritis
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Identify the type of SpA.
Symptoms: Associated with ulcerative colitis and Crohn's disease |
Enteropathic arthritis
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