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8 Cards in this Set
- Front
- Back
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Gain knowledge of the incidence and prevalence of the major gynecologic malignancies
Understand risks associated with development of each malignancy Gain familiarity with workup involved in diagnosis and staging Understand appropriate treatment options for stage of disease |
objectives
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Most common pelvic gynecologic malignancy in women (6% of all cancers in women)
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Endometrial Cancer
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Endometrial Cancer Risk Factors
Obesity: being overweight by more than 20-50 lbs increases risk HOW MUCH, being overweight by more than 50 lbs increases risk by 10-fold |
3 x
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Endometrial Cancer Risk Factors
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Endogenous estrogen excess
Polycystic ovary disease Anovulatory menstrual cycles Obesity Granulosa cell tumor of the ovary (or other estrogen-secreting tumors) Advanced liver disease Endogenous prolonged estrogen exposure Irregular menses, infertility, and nulliparity Tamoxifen Type II DM Hypertension Family history Personal history of breast, ovary or colorectal ca, or family hx c/w HNPCC (Lynch II syndrome) |
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n__________ women have twice the risk of developing uterine cancer compared to women with one child and 3x risk compared to women who have given birth to five or more children
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nulliparous
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Endometrial Cancer Protective Factors
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Oral contraceptives-50% decrease in RR when oral contraceptives are used for at least 12 months. Protection lasts for at least 10 years after discontinuation
Physical activity Breast feeding |
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Endometrial Cancer:
Type what?-Estrogen related. More common type associated with DM and obesity. Tumor is more differentiated with more favorable histologic subtypes, higher incidence of superficial invasion, lower grade, stage and younger patients |
I
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Endometrial Cancer: Type what?- Unrelated to estrogen stimulation and endometrial hyperplasia. Less common with short duration of symptoms, poor differentiation, deep invasion, poor prognosis and more aggressive histology.
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II
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