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20 Cards in this Set

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Morphine
mu agonist; opiod analgesic that causes itchy pruritis; 6-glucuronide (active) while 3-glucuronide (inactive)
Hydrocodone
mu agonist; demethylzed to active metabolite hydromorphone by CYP2D6; APAP can cause hepatoxocity
Meperidine
opioid analgestic; mu agonist; t1/2 < morphine; normeperidine metabolite can cause convulsions
methadone
opioid analgesic; mu agonist, oral absorption >morphine, crosses BBB more slowly than morphine, t1/2 greater than morphine
fentanyl
opiod; mu agonist; higher potency than morphine
oxycodone
opiod; mu agonist; effects enhanced by cimetidine
codeine
opiod that requires conversion to morphine for effect; mu agonist with ceiling on maximum analgesic effect, oral absorption>morpine, crosses BBB more rapidly than morphine
butorphanol
opiod; K agonist
buprenorphine
opiod; partial mu agonist, potency > morphine; long duration of action for maintenance programs
tramadol
weak mu agonist; weak inhibitor of NE and 5HT reuptake
loperamide
mu agonist poorly absorbed following PO and does not cross BBB; used for diarrhea
nalaxone
opiod antgonist; t1/2 <morphine
naltrexone
opiod antagonist; t1/2 >morphine
methylnaltrexone
mu antagonist does not cross the BBB; used to treat opioid induced constipation in patients with advanced illness who are receiving palliative care
alvimopan
mu antagonist does not cross BBB; uced to treat post operative ileum after bowel resection
gabapentin
anticonvulsant used for neuropathic pain
topiramate
anticonvulsant used for neuropathic pain
amitriptyline
TCA for neuropathic pain and antidepressant in chronic pain
duloxetine
SNRI antidepressant used for neuropathic pain and as an antidepressant in chronic pain
trihexyphenidyl
mAchR antagonist used in the treatment of Parkinson's disease and in combo with antipsychotic drugs to control EPS