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20 Cards in this Set
- Front
- Back
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Morphine
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mu agonist; opiod analgesic that causes itchy pruritis; 6-glucuronide (active) while 3-glucuronide (inactive)
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Hydrocodone
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mu agonist; demethylzed to active metabolite hydromorphone by CYP2D6; APAP can cause hepatoxocity
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Meperidine
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opioid analgestic; mu agonist; t1/2 < morphine; normeperidine metabolite can cause convulsions
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methadone
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opioid analgesic; mu agonist, oral absorption >morphine, crosses BBB more slowly than morphine, t1/2 greater than morphine
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fentanyl
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opiod; mu agonist; higher potency than morphine
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oxycodone
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opiod; mu agonist; effects enhanced by cimetidine
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codeine
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opiod that requires conversion to morphine for effect; mu agonist with ceiling on maximum analgesic effect, oral absorption>morpine, crosses BBB more rapidly than morphine
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butorphanol
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opiod; K agonist
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buprenorphine
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opiod; partial mu agonist, potency > morphine; long duration of action for maintenance programs
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tramadol
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weak mu agonist; weak inhibitor of NE and 5HT reuptake
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loperamide
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mu agonist poorly absorbed following PO and does not cross BBB; used for diarrhea
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nalaxone
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opiod antgonist; t1/2 <morphine
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naltrexone
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opiod antagonist; t1/2 >morphine
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methylnaltrexone
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mu antagonist does not cross the BBB; used to treat opioid induced constipation in patients with advanced illness who are receiving palliative care
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alvimopan
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mu antagonist does not cross BBB; uced to treat post operative ileum after bowel resection
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gabapentin
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anticonvulsant used for neuropathic pain
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topiramate
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anticonvulsant used for neuropathic pain
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amitriptyline
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TCA for neuropathic pain and antidepressant in chronic pain
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duloxetine
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SNRI antidepressant used for neuropathic pain and as an antidepressant in chronic pain
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trihexyphenidyl
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mAchR antagonist used in the treatment of Parkinson's disease and in combo with antipsychotic drugs to control EPS
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