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877 Cards in this Set

  • Front
  • Back
What is the incidence of SCI per year per million people
40 per million; 11,000 new cases per year
What is the prevelance of SCI?
250,000
What is the male:female ration of SCI?
4:1
What is the average age of SCI?
38
Older than 60 accounts for what % of cases?
11.5%
What are the two most common causes of SCI
MVA follow by falls
What is the most common sports related SCI cause?
diving
What are the two most common causes of SCI in the elderly
falls then MVA
What month has the highest incidence of SCI?
July
What day of the week is most common for a SCI?
Saturday
What is the most common level of injury?
C5
What is the most common level of paraplegia?
T12
What percent of SCI is incomplete tetraplegia?
34.1%
What percent of SCI is complete paraplegia?
23%
What percent of SCI is complete tetraplegia?
18.3%
What percent of SCI is incomplete paraplegia?
18.5%
What is the most common form of SCI injury?
incomplete tetraplegia
What marriages survive better, pre or post injury?
post injury
Most SCI are single or married?
single (51%)
What is the post SCI employment rate?
25%
What is a predictor of return to work in SCI?
ability to drive
also, white, male, younger, educated
What level injury in SCI is a predictor of mortality?
C4
What social profile is a predictor of mortality?
poor community integration
What insurance profile is a predictor of mortality?
medicaid or medicare
Which is a predictor of mortality, complete or incomplete neurological?
complete neurological
What is the most common cause of mortality in SCI?
pneumonia
What are the second and third most common causes of mortality in SCI?
heart disease then septicemia
What is the second most common cause of death in SCI younger than 25?
suicide
What age range in SCI has the highest suicide rates?
<25 years old
What are two leading causes of death in incomplete paraplegia?
cancer and suicide
What are the first and second leading causes of death in complete paraplegia?
suicide, then heart disease
How many sacral vertabrae?
5
How many coccygeal vertabrae?
4
How many thoracic vertabrae?
12
What is the terminal portion of the spinal cord?
conus medullaris
Proprioception from the leg are carried in these fibers?
fasciulus gracile: medial dorsal columns
Proprioception from the arms are carried in these fibers.
fasciculus cuneate: lateral dorasl columns
What sensations are carried by the spinocerebellar tracts
muscular position and tone
Pain and thermal sensation are carried by what fibers?
lateral spinothalamic
Neck and trunk movements are carried by what tracts?
anterior corticospinal tract
Proprioception from the arms are carried in these fibers.
fasciculus cuneate: lateral dorasl columns
What are the main tracts for carrying voluntary muscle activity?
lateral corticospinal tracts
What sensations are carried by the spinocerebellar tracts
muscular position and tone
Pain and thermal sensation are carried by what fibers?
lateral spinothalamic
Neck and trunk movements are carried by what tracts?
anterior corticospinal tract
What are the main tracts for carrying voluntary muscle activity?
lateral corticospinal tracts
What is the course of the lateral corticospinal tracts starting with the orgin in the brain and transversing 3 structures.
precentral gyrus
internal capsule
medulla oblongata
Where do the lateral corticospinal tracts cross over to the contralateral side?
pyramidal decussation of the medulla
What percentage range of lateral corticospinal fibers cross over?
80-90%
Where do white matter lateral corticospinal tract fibers enter gray matter?
at the ventral horn
Where do UMN and LMN synapse?
Gray matter ventral horn
In what tracts do the fibers that do not decussate at the pyramidal decussation in the medulla travel?
ventral corticospinal tracts
What tracts transmit unconscious proprioception? Are they contralateral or ipsilateral
spinocerebellar tracts/ipsilateral
Lateral spinothalamic tracts transmit pain and temperature contra or ipsilateral?
contralateral
Where do the lateral spinothalamic fibers synapse?
dorsal horn of the gray matter
What is the course through 3 structures of the lateral spinothalamic tracts to the brain?
thalamus
internal capsule
postcentral gyrus of the cerebral cortex
Where do lateral spinothalamic tracts cross over?
within 1-3 segments of entering the cord at the dorsal horn
A lesion of the lateral spinothalamic tract will result in a ipsi or contralateral loss of pain and temperature?
contralateral below the level of the lesion
Cerebellar lesions affecting the spinocerebellar tracts will result in a ipsi or contralateral loss?
ipsilateral loss
What sensation is transmitted by the dorsal or posterior columns?
ipsilateral
What three senses are transmitted by the dorsal columns?
proprioceptoin, fine touch, and vibration
Where do lateral spinothalamic tracts cross over?
within 1-3 segments of entering the cord at the dorsal horn
A lesion of the lateral spinothalamic tract will result in a ipsi or contralateral loss of pain and temperature?
contralateral below the level of the lesion
Cerebellar lesions affecting the spinocerebellar tracts will result in a ipsi or contralateral loss?
ipsilateral loss
What sensation is transmitted by the dorsal or posterior columns?
ipsilateral
What three senses are transmitted by the dorsal columns?
proprioceptoin, fine touch, and vibration
Where do lateral spinothalamic tracts cross over?
within 1-3 segments of entering the cord at the dorsal horn
A lesion of the lateral spinothalamic tract will result in a ipsi or contralateral loss of pain and temperature?
contralateral below the level of the lesion
Cerebellar lesions affecting the spinocerebellar tracts will result in a ipsi or contralateral loss?
ipsilateral loss
What sensation is transmitted by the dorsal or posterior columns?
ipsilateral
What three senses are transmitted by the dorsal columns?
proprioceptoin, fine touch, and vibration
Where do fibers of the dorsal column synapse?
dorsal root ganglion
Are dorsal column fibers ipsi or contralateral?
ipsilateral
Do fibers of the DRG ascend in white or gray matter?
white
Where do dorsal column fibers decussate?
medulla
Dorsal column axons carrying signals from the sacral and lumbar areas are located in what part of the dorsal column and whtat is this structure called in the medulla?
medial part of the dorsal column
fasciculus gracilis
Dorsal column axons carrying signals from the upper extremity and thoracic areas are located in what part of the dorsal column and whtat is this structure called in the medulla?
lateral part of the dorsal column
fasciculus cuneatus
Fibers of the fasciculus cuneatus and gracilis coalesce to form what structure before ascending higher in the brain?
medial lemniscus
Where do fibers of the fasciculus cuneatus and gracilis synapse before forming the medial lemniscus?
they synapse in the medulla
Where do medial lemniscus fibers terminate?
postcentral gyrus of the cerebral cortex
A lesion of the dorsal column results in an ipsi or contralateral loss?
ipsilateral
How many anterior and posterior spinals arteries are there?
1 anterior/2 posterior
The anterior spinal artery supplies what portion of the spinal cord?
anterior 2/3 of the spinal cord
What arteries supply the posterior 1/3 of the spinal cord?
posterior spinal arteries
What is the origin of the posterior spinal arteries?
vertebral arteries
The artery of Adamkiewicz arises on the left or right?
left
What is the blood supply of the lower 2/3 of the spinal cord?
Artery of Adamkiewicz
What is the orgin of the artery of Adamkiewicz?
intercostal or lumbar artery
What is the level range where the artery of adamkiewicz enters the spinal cord?
T6-L3
What is the watershed area area of the thoracic cord that is most vulnerable to injury when there is low blood flow such as during cross clamping of the aorta?
T4-6
What is the primary venous drainage of the spinal cord?
internal venous plexus
What level is the most common cervical compression fracture?
C5
A unilateral facet dislocation is unstable if what ligament is disrupted?
posterior ligament
What is the most common level of a unilateral facet dislocation?
C5-C6
A unilateral facet dislocation is noted by what percentage dislocation of the verterbral body?
<50%
What is the most common level of bilateral facet joint dislocation in the cervical spine?
C5-C6
A unilateral facet disclocation is more likely to be an incomplete or a complete neurological injury?
incomplete
A bilateral facet dislocation is more likely to be an neurologically incomplete or complete injury?
complete
What is the most common level for a cervical hyperextension injury?
C4-C5
A cervical hyperextension injury in the elderly may result in what syndrome?
central cord syndrome
What is the most common activity resulting in flexion/axial loading mechanism of injury and what level is most commonly affected?
diving/C5
A bilateral facet joint dislocation results in what percentage dislocation of the vertebral body on xray?
>50%
What is the MOI of a bilateral facet joint dislocation?
flexion
Where is the weakness in a central cord syndrome; UE compared to LE?
UE weakness>LE weakness
A central cord syndrom is likely to be incomplete or complete injury?
incomplete
What ligament may be disrupted in a hyperextension injury central cord syndrome?
anterior longitudinal
What vitamin deficiency can cause of NT SCI?
B12 deficiency
What are the two most common etiologies of NT SCI?
spinal stenosis and spinal cord tumors
What is the female:male ratio of transverse myelitis?
4:1 females:males
What are three predictors of poor outcome in transverse myelitis?
rapid progression
back pain
spinal shock
What are the two most common underlying conditions of epidural abscess?
diabetes
immunocompromise
Incidence of radiation myelopathy is correlated with what three metrics?
total radiation dose
dose fraction
length of cord irradiated
What syndrome sometimes develops in radiation myelopathy?
Brown-Sequard
What are the two primary symtpoms of radiation myelopathy?
weakness
loss of sensation
What percentage of spinal cord tumors are extradural?
95%
In what section of the cord are metasteses most common?
thoracic
What are the two cardinal symptoms of a spinal cord tumor?
night pain
supine pain
What are the two most common primary spinal tumors?
ependymoma
astrocytoma
What are the 3 most common sources of metastatic spinal tumors?
lung
breast
prostate
What is the most common type of NT SCI in over 50 age group (i.e. complete or incomplete)?
incomplete
What are the NT SCI FIM scores compared to traumtic SCI FIM scores upon dischage
the same
What are 6 indicators of favorable home discharge in NT SCI?
incomplete
married
skin intact
bladder/bowel program
cognitively intact
male
What is the most restrictive of the removable cervical collars?
Minerva
What is the most restrictive of the non-removable cervical collars?
Halo
What is more restrictive SOMI or 4 poster?
4-poster
What is the least restrictive cervical collar?
soft collar
Name three injuries that are most office complete.
bilateral facet dislocations
transcanal GSW
TL flexion rotation injuries
TL flexion rotation injury is most often what type of injury (complete or incomplete)?
complete
Falls with underlying cervical spondylosis usually result in what type of injury (complete or incomplete?
incomplete
Name three injuries that are most often incomplete?
falls with underlying spondylosis
non-transcanal GSW
unilatateral facet dislocation
Where is a Jefferson fx?
C1
Are Jefferson fxs usually stable or unstable?
stable
What is the orthosis for a Jefferson fx?
halo
Does a Jefferson fx usually present with neuro findings?
no
Where is a hangman's fx?
C2 burst fx
What is a sports MOI for a Jefferson fx?
football spearing (axial loading)
What is the MOI for a Hangman's fx?
deceleration (head hitting windsheild)
What is the orthosis for a Hangman's fx?
halo
Where is a type I dens fx? and what is the tx?
tip of dens; no tx
What type of odontoid fx is most common? and where is it?
Type II - fx through base of odontoid at junction with C2
What element of the spine are fx'd in a Chance fx?
spinous process, pedicles, vertebral body
A Chance fx is most commonly seen at what 3 levels?
T12, L1, and L2
What is the MOI in a Chance fx?
hyperflexion of the thorax
Are Chance fxs usually associated with neurologic injury?
No
What are two MOI of spinal cord injury without radiologic abnormality (SCIWORA)?
traction in a breech delivery
violent hyperextension or hyperflexion
What ratio predisposes to SCIWORA during breech?
large head:neck ratio
What is the MOI in an adult SCIWORA?
fall with hyperextension of the neck
What syndrome can arise from a adult hyperextension cervical SCIWORA?
central cord syndrome (UE>LE weakness; C4-5)
In an adult cervical SCIWORA from a hyperextension fall what structure can narrow the canal by as much as 50%?
ligamentum flavum
Paraplegia refers only to injury where?
thoracic and below
What are the 3 brain structures that an UMN traverses before going into the spinal cord?
prefrontal motor cortex
internal capsule
brainstem
What are 3 UMN finding?
hyperreflexia
babinski
detrusor sphincter dyssynergia
What is the origin of LMNs?
anterior horn cells
What are 4 classic signs and symptoms of LMN injury?
hyporeflexia
flaccid weakness
muscle atrophy
areflexic/hypotonic bladder
To perform a SCI classification exam what position is the patient?
supine
How many dermatomes are tested in SCI classification?
28
An area of skin innervated by the sensory axons within each segmental root is called what?
dermatome
What is the sensory control in SCI classification?
the face
What type of material is used for light touch testing?
cotton tip applicator
Where is the S4-5 dermatome?
perianal
What is the sensory of level of an injury?
Most caudal area with 2/2 pinprick and light touch
What is C2 sensory?
occipital protuberance
What is C3 sensory?
supraclavicular fossa
What is C4 sensory?
Superior AC joint
What is C5 sensory?
lateral side of antecubital fossa
What is C6 sensory?
Thumb
What is C7 sensory?
middle finger
What is C8 sensory?
little finger
What is T1 sensory?
medial antecubital fossa
What is T2 sensory?
apex of axilla
What is T3 sensory?
third intercostal space mid-clavicular line
What is T4 sensory?
nipple
What is T5 sensory?
fifth intercostal space
What is T6 sensory?
xiphoid
What is T7 sensory?
7th intercostal space
What is T8 sensory?
8th intercostal space
What is T9 sensory?
9th intercostal space
What is T10 sensory?
10th intercostal space
What is T11 sensory?
11th intercostal space
What is T12 sensory?
inguinal ligament
What is L1 sensory?
halfway between T12 and L2
What is L2 sensory?
thigh
What is L3 sensory?
medial femoral condyle
What is L4 sensory?
medial malleolus
What is L5 sensory?
3rd MTP joint dorsum of foot
What is S1 sensory?
lateral heel
What is S2 sensory?
popliteal fossa
What is S3 sensory?
ischial tuberosity
What is a myotome?
collection of muscle fibers innervated by the motor axons with each segmental nerve
How many myotomes are tested in SCI classification?
10
What is the C5 muscle/action
biceps/elbow flexion
What is the C6 muscle/action?
extensor carpi radialis/wrist extensors
What is the C7 muscle/action?
triceps/elbow extensor
What is the C8 muscle/action?
flexor digitorum profundus/finger flexor
What is the T1 muscle/action?
abductor digiti minimi/small finger abductor
What is the L2 muscle/action?
iliopsoas/hip flexion
What is the L3 muscle/action?
quadriceps/knee extensor
What is the L4 muscle/action?
tibialis anterior/ankle dorsiflexors
What is the L5 muscle/action?
extensor hallicus longus/long toe extensors
What is the S1 muscle/action?
ankle plantar flexors
What is the muscle score for active movement full range no gravity?
2
What is the muscle score for active movement against gravity?
3
What is the motor level of injury?
most caudal muscle = or >3 with the segments above 5/5
What is the neurological level of injury?
most caudal segment with both normal sensory and motor (> or = to 3 with cephalad segments 5/5) on both sides of the body
What is the most caudal cervical level where is there no motor level
C4
A person with a C5 muscle having 2/5 strength with a C4 sensory level has what neurological level?
C4
What is sacral sparing?
At least voluntary impaired anal sphincter contraction OR intact light touch OR pinprick on either side
OR
anal sensation on rectal exam
Zone of partial preservation (ZPP) is used only with what type of injury, complete or incomplete?
complete
What is the ZPP?
dermatomes and myotomes caudal to the NLI that remain partially innervated
Sacral sparing indicates integtiy of what matter, gray or white? what tracts?
white/corticospinal and spinothalamic
What is the impairment of no motor or sensory at S4-5?
Asia A complete
Sensory but not motor function is preserved below the neurological level and includes S4-5 is called?
Asia B incomplete
Motor function is preserved below the NL and more than half of the key muscles below the NL have a grade of less than 3 is called what?
Asia C incomplete
Motor function is preserved below the NL and at least half of key mueslces below the NL have a grade of 3 or more is called what?
Asia D incomplete
Motor and sensory functions are normal is called what?
Asia E
To receive a grade of Asia C or D the injury must be complete or incomplete?
incomplete
An incomplete injury means there is sparing of one of what two functions?
sensory or motor function in S4-5
To receive a grade of Asia C or D the injury must be complete and have one of what other two functions?
voluntary anal sphincter contraction
or
sparing of motor more than 3 levels below the motor level
In a region without a myotome, what is the motor level?
the same as the sensory level
What is the motor level?
> or = to 3 with all above levels 5/5
What is the sensory level?
The most caudal level of 2/2 with a 1 or 0 below it.
Motor function preserved below NI can be either what two ASIA scores?
C or D
What determines Asia D?
half of muscles below NI are > or = 3
What determined Asia C?
half of muscle below NI are < 3
If no deficits are found at initial testing what is the Asia score?
E
Temporary loss or depression of all spinal reflex activity below the level of the lesion is called what?
spinal shock
What are two muscle reactions to spinal shock?
flaccid and hyporeflexic muscles below the lesion
What are bladder/bowel reactions to spinal shock?
paralysis of bladder and bowel
What is a foot sign of spinal shock?
delayed plantar response
What is delayed plantar response?
Deep pressure over the Babinski area; the toes flex and relax slowly
What is the prognois for a persistent delayed plantar response?
poor prognosis for LE recovery
What reflex usually returns within 24 hours after SCI?
bulbocavernosus reflex
The return of the bulbocavernosus reflex indicates that the injury is UNM or LMN?
UMN
If the bulbocavernosus reflex does not return within 24 hours what type of injury is suspected UMN or LMN?
LMN
What reflex and its implication is similar to the bulbocavernosus reflex?
perianal sphincter reflex - anal wink
List the order of return of reflexes from early return to late.
delayed plantar response
bulbocavernosus
anal wink
Reflexes after SCI begin to return in what time frame?
within 24 hours
What is the normal time frame of full restoration of reflexes after SCI? and maximum time?
2-3 weeks, but up to 3 months
Reflexes below the lesion, when they return, are hypo or hyper?
hyper
What is the most common of the SCI syndromes?
Central cord
Central cord syndrome is what % of total SCI?
9%
What are 3 signs of central cord syndrome?
UE weakness>LE weakness
sacral sensory sparing
normal bowel/bladder function
Central cord is predominately a gray or white matter injury?
white matter
What is the typical demographic and MOI in central cord syndrome?
hyperextension injury in senior with cervical spondylosis
In central cord syndrome, what strength recovers first, UE or LE?
LE strength recovers first
In central cord, what recovers first, UE proximal or distal muscle strength?
proximal
What is a key demographic prognostic indicator of functional recovery?
age below 50
A Brown-Sequard is essentially what type of injury to the cord?
hemisection
With what MOI is Brown Sequard classically associated?
stab injury
In Brown Sequard sensory loss at the level of lesion is ipsi or contra?
ipsi
In Brown Sequard motor loss at the level of lesion is ipsi or contra?
ipsi
In Brown Sequard what is the type of motor loss paralysis, flaccid or spastic?
flaccid
In Brown Sequard there is ipsilateral loss of what sensory functions below the level of lesion?
position and vibration loss below the level of lesion
In Brown Sequard position and vibration loss below the level of lesion is ipsi or contra?
ipsi
In Brown Sequard what sensory functions are lost contralateral?
pain and temperature
In Brown Sequard pain and temperature loss below the level of lesion is ipsi or contra?
contra
What are the two most common presenting signs of Brown Sequard?
*Contralateral loss of pain and temperature
*Ipsilateral loss of position and motor
What columns are preserved in anterior cord syndrome?
posterior cords
What type of injury can result in anterior cord, flexion or extension injuries?
flexion
What 3 sensations are preserved in anterior cord?
proprioception
light touch
deep pressure
In anterior cord what portion of the cord is affected?
anterior 2/3s
What two tracts are usually injured in anterior cord? and what are the symptoms associated with damage to each tract?
corticospinal - muscle weakness
spinothalamic - pain/temperature sensitivity
Posterior cord syndrome results in primarily what deficit?
proprioceptive
What columns are affected in posterior cord?
dorsal
What are the two primary deficity in conus medullaris syndrome?
areflexic bladder and bowel
areflexic LEs
In a high conus lesion what two reflexes are preserved?
bulbocavernosus
micturation
What is the level of the conus?
L1-L2 vertabrae
Injuries below L1-2 can result in what syndrome?
cauda equina syndrome
Cauda equina syndrome is a UNM or LMN injury?
LMN
What are 4 hallmark signs/symptoms of cauda equina?
weakness
atrophy
impotence
areflexia at ankle and plantar
What LE reflex is preserved in cauda equina?
knee jerk (L4)
In cauda equina is the bulbocavernosus preserved or absent?
absent
Cuada equina has a better/worse prognosis than UMN injuries?
better
What is a congenital cause of conus medullaris?
spina bifida
What is a orthopedic cause of conus medullaris?
T12- L1 fx
Is conus medullaris an UMN or LMN syndrome?
LMN
What is the loss of sensory distribution called in conus?
saddle
Is conus symmetric or assymetric?
symmetric
What are 3 dysfunctions in conus?
bladder, bowel and sexual dyfunction
What nerve roots are typically involved with conus medullaris?
S1-S5
Is motor in LEs normal or abnormal in conus medullaris?
normal
A high conus lesion will result in presence of what reflex
bulbocavernosus
Is pain prominent in conus medullaris?
no
In conus, the highest and lowest levels of injury are what?
T12/L2
Below what level is the injury in cauda equina?
below L2
Can lumbar spondylosis be associated with cauda equinus?
yes
What three areas of fracture can cause cauda equina?
fx below L2
sacral fx
pelvic fx
What type of paralysis is present in cauda equina? flaccid or spastic
flaccid
Is cauda equina an UMN or LMN injury?
LMN
Are the deficits in cauda equina symmetric or assymetric?
asymmetric
High cuada equina lesions spare functions of what two organs?
bladder/bowel
Cauda equina lesions causing bowel, bladder, and sexuaal dysfunction are located at what level range?
S3-5
What reflex is absent in sacral cauda equina lesions?
bulbocavernosus reflex
In cauda equina are LE reflexes hyper or hypo reflexic?
hypo or areflexic
In conus in the EMG normal or abnormal?
normal
In conus, motor function is normal unless what level is affected?
S1-2
An abnormal EMG in conus medullaris is due to injury in onr or more of what 3 areas?
external sphincter
S1
S2
Is the EMG in cauda equina normal or abnormal?
abnormal according to the root level involved
C1-4 SCI patients are independent using a power WC in what two areas of ADLs?
weight shifts
WC propulsion
A C5 quad is absolutely dependent in what two areas?
LE dressing
bathing
What level quad can drive with adaptations/
C5
What level quad is independent in feeding with adaptive equipment after set-up?
C5
A C6 quad is independent without assistance or adaptive equipment in what two ares?
UE dressing
weight shifts
What level quad is independent using manual WC on level surfaces?
C6
What level quad is independent in manual WC except for curbs and uneven terrain?
C7
What level quad is independent in transfers with or without board for level surfaces?
C7
A C8 quad is independent in all areas without equipment except what one ADL area that requires equipment, not including driving with hand control or adapted van?
bathing
What level quad in independent in feeding without equipment?
C6
T2-S5 paras are absolutely independent in what 3 areas of living?
all ADLs
bowel/bladder
transfers
What level para range can stand in a frame, tilt table or standing WC?
T2-9
What is the LE orthosis for a T2-9 para?
bilat KAFO
What type of crutches for a T2-9 para?
forearm crutches
What level range para is capable of household ambulation with orthoses?
T10-L2
What type of braces and crutches are necessary for a T10-L2 para?
KAFO with forearm crutches
What level para is capable of community ambulation?
L3-S5
What is the highest level, extremely movitivated quad that can live independantly without the aid of an attendant?
C6
A C6 living indendently uses what type of kinetic chain, open or closed, to accomplish a transfer?
closed
A C6 living independently must stabilize what joint extension to accomplish the transfer?
must stabilize elbow extension
What is the usual quad level for acheiving independence?
C7
What is the level at which and above are autonomic dysreflexia and orthostatic hypotension considered a risk?
T6 and above
A T6 and above para is at risk from what two complications?
autonomic dysreflexia
orthostatic hypotension
At what level and above is a para unable to self-regulate normal body temperature?
T8 and above
A T8 and above para is unable to regulate what body function?
body temperature
Where in the brain is temperture regulation controlled?
hypothalmus
There is a lack of sympathetic or parasympathetic outflow that causes orthostatic hypotension?
lack of sympathetic outflow
Tilting the patient to what degree will trigger orthostatic hypotension?
>60 degrees
Autonomic control of heart and blood vessels is located in what thoracic level range?
T1-T7
What level range control arterial pressure, tachycardia and vasoconstriction?
T1-L2
Hypotension in SCI is due to decreased what?
decreased pre-load
What is a positional treatment for orthostatic hypotension?
trendelenburg
What is a fluid intake treatment for orthostatic hypotension?
increase fluids
What are three pharma treatments for orthostatic hypotension?
salt 1gm qid
midodrine
florinef
What is the class of drug of midodrine?
alpha 1 adrenergic agonist
Having orthostatic hypotension puts patient at risk for what other complication?
autonomic dysreflexia
AD is due to the loss of what autonomic function?
descending central sympathetic control
In the pathology of AD sympathetic receptors are hyper or hyposensative?
hypersensitive
What two circulatory parameters increase in AD?
cardiac output
blood pressure
The AD the brainstem is unable to send messages to the splanchic bed to allow vasoconstriction or vasodilation to decrease BP?
vasodilation
In what timeframe after SCI does AD usually occur?
2-4 weeks post injury
Classically AD occurs in complete or incomplete SCI?
complete, but can occur in incomplete
What is the most common cause of AD?
bladder overdistension or infection
The stimulus setting off AD occurs above or below the SCI injury?
below
What are two classic symptoms of AD?
flushing and sweating ABOVE the level of injury
Name three other typical symptoms of AD?
increased BP
constricted pupils
headache
What is a positional treatment for AD?
sit patient up
What is a urinary tx for AD if bladder is suspect as stimulus for AD?
remove catheter, straight cath, tx UTI if present
How often should BP be checked in AD?
every 2-5 minutes
What are 4 ICU agents used to rx elevated BP in AD?
labetolol
nitropaste
hydralazine
diazoxide
What two classes of agents can be used to help prevent AD?
beta blockers
alpha blockers
What type of anesthesia is recommended for delivery in a T6 or above para?
spinal anesthesia
Spinal anesthesia is recommended for labor in a SCI at what level or above?
T6 or above
AD predisposes a patient to what heart condition?
atrial fib
What type of arryhthmias are more common in AD?
re-entrant type arrhythmias
Tachycardia in orthostatic hypotension is due to sympathetic outflow of what baroreceptors?
aortic and carotid
What class of med is florinef?
mineralcorticoid
Orthostatic hypotension results from a inability of the splanchnic bed to vasodilate or vasoconstrict?
vasoconstrict upon assuming upright position
Where is the inhibitor of the parasympathetic sacral micturation center? nuclei and lobes
Corticopontine mesencephalic nuclei in the frontal lobesq
What does the inhibition of the parasympathetic sacral micturation center allow?
bladder storage
Where is the coordination of bladder contraction and sphincter relaxation?
pontine mesencephalic nuclei in the pons
What urinary function occurs in the pons?
coordination of bladder contratction and sphincter relaxation
Loss of urinary control in the pons results in what condition?
detrusor sphincter dyssynergia
Detrusor sphincter dyssynergia arises out of a lesion in what area (nuclei and location)
pontine mesencephalic nuclei in the pons
Pelvic and pudendal nuclei control what micturation center?
sacral micturation
What is the function of pelvic and pudendal nuclei?
mediate parasympathetic S2-S4 sacral micturation reflex
What area voluntarily controls the external urethral sphincter?
motor cortex to the pudendal nucleus
Where is the detrusor nucleus controlling bladder contraction and emptying?
intermediolateral gray matter of the sacral cord at S2-4
Bladder contraction and emptying is a sympathetic or parasympathetic function?
parasympathetic
What type of receptors cause bladder contraction and emptying in response to parasympathetic action?
cholinergic
Where is the origin of sympathetic efferents?
T11-L2
What level range are the parasympathetic efferents controlling bladder contraction and emptying?
S2-S4
Sympathetic efferents to the bladder synapse on what two receptors?
alpha-1 and beta-2 adrenergic
Where are beta-2 adrenergic receptors located?
body of bladder
What is the function of beta-2 adrenergic receptors?
smooth muscle relaxation allowing bladder to fill
Where are two urinary system locations of alpha-1 receptors?
base of bladder and prostatic urethra
What is the function of alpha-1 adrenergic receptors in the urinary system?
smooth muscle contraction in the urine and causing storage of urine
What is the origin of the somatic efferents of the urinary system? nucleus and spinal level range
pudendal nucleus of S2-S4
What peripheral nerve carries fibers the urinary system?
pudendal
What type of muscle does the pudendal nerve stimulate, striated or smooth?
striated
What structure does the pudendal nerve innervate?
external urethral sphincter
What is the function of the external urethral sphincter?
voluntary contraction prevents leakage or emptying
Afferent fiber originate in what 5 structures?
detrusor stretch recptors
external anal sphincter
external urethral sphincter
perineum
genitalia
What two nerves carry afferents to the sacral cord?
pelvic and pudendal nerves
What type fibers in the pelvic and pudendal nerves respond to bladder distention?
myelinated a-delta fibers
What fibers are more active following SCI?
C-fibers
What two meds in SCI are used to control unihibited contractions, and what type fibers are targeted?
capsaicin, resiniferatoxin
C-fibers
What type of fibers of what spinal level range are carried by the hypogastic nerve?
sympathetic/T11-L2
The internal urethral sphincter in innervated by what nerve?
hypogastric
What is the function of the internal urethral sphincter?
hypogastric nerve contracts sphinter and promotes urine storage
What nerve and spinal level range innervates the external sphincter?
pudendal nerve
S2-S4
Is the control of the pudendal nerve involuntary or voluntary?
voluntary -skeletal muscle
Is the control of the hypogastric nerve voluntary or involuntary?
involuntar -smooth muscle
In what 4 structures of the urinary system are cholanergic muscarinic receptors located?
bladder wall
trigone
bladder neck
urethra
In what 2 urinary structures are Beta-2 adrenergic receptors located?
bladder
bladder neck
What binds to Beta-2 adrenergic receptors?
norepinephrine
What does norepinephrine binding to beta-2 receptors cause?
bladder relaxation
In what 2 urinary structures are Alpha-1 adrenergic receptors located?
base of bladder
prostatic urethra
What molecule binds to alpha-1 adrenergic receptors?
norepinephrine
What does norepinephrine binding to alpha-1 adrenergic receptors cause?
bladder contraction
Activation of alpha-1 and beta-2 adrenergic receptors originates in sympathetic efferents from what spinal levels through what nerve?
T11-L2/hypogastric nerve
Activation of alpha-1 and beta-2 receptors allows what to happen?
storage of urine
Activation of what adrenergic receptors allow bladder wall expansion?
beta-2 adrenergic receptors relaxes bladder wall to allow storage of urine
Bladder emptying originates in the spinal cord at what level range?
S2-4
What "tone" predominates during urination, sympathetic or parasympathetic?
parasympathetic
Parasympathetic efferents travel through what nerve to the bladder?
pelvic nerves
S2-S4 parasympathetic efferents activate what receptors?
cholinergic muscarinic (M2) receptors
In what 4 urinary structures are cholinergic muscarinic receptors located?
bladder wall, trigone, neck, and urethra
What neurotransmitter activates cholinergic muscarinic receptors? What does it cause the bladder to do?
acetylcholine/contract, causing urination
What receptors are activated (by what neurotransmitter?)upon voiding to cause relaxation of the bladder neck?
norepinephrine/beta-2 adrenergic
What 3 parameters are measured during cystometry?
sensation
capacity
presence of involuntary detrusor activity
At what ml is there a sensation of bladder filling?
100ml
What sensory parameter controls first urge to void and strong urge to void?
proprioception
Functional bladder capacity is the sum of what two measures?
voided volume + residual volume
voided volume + residual volume = what
function bladder capacity
What is the accepted range of normal bladder capacity?
300-600ml
What is the reflex status of a bladder in spinal shock?
areflexic
An areflexic bladder retains or voids urine?
retains
What is the time frame range of return of bladder reflexes?
2-12 weeks
What is the time frame range(in days) for starting an indwelling catheter program post injury?
7-15 days
What is the initial fluid restriction (in L/day) of an SCI patient
2L/day
At what ml fill range is there a sense of urgency?
400-500cc
At what ml fill range is there a sense of bladder fullness?
300-400cc
During normal bladder fill does intravesical pressure increase significantly?
no
During normal voiding what is the status of the EMG signal?
silent
What happens to the intravesical pressure during normal voiding?
increases
What happens to the urethral pressure during voiding?
decreases
What is a long term possible complication an indwelling catheter?
cancer
Intermittent catheterization volumes should be less than what volume (cc)
500 cc
What are the two causes of vesicoureteral reflux?
bladder wall hypertrophy
loss of vesicoureteral angle
Bladder wall hypertrophy and
loss of vesicoureteral angle can cause what phenomenon?
vesicoureteral reflux
Maintaining bladder volumes <500ml will help prevent what 3 complications of intermittent catheterization?
vesicoureteral reflux
hydro-ureter
overflow incontinence
What is the the basic urinary problem with a LMN bladder?
failure to empty
What are the two direct causes of failure to empty bladder? (bladder and sphincter tone characterization)
flaccid bladder
spastic sphincter
What are 3 spinal cord syndromes resulting in a flaccid bladder/failure to empty problem?
cauda equina syndrome
conus medullaris syndrome
syringomyelia
What is a brain injury cause of flaccid bladder/failure to empty?
acute CVA
At what spinal level is the lesion causing failure to empty?
sacral micturation center (S2-S4
A LMN/flaccid bladder/failure to empty condition arises out of a peripheral nerve or central innervation problem?
peripheral nerve
What is the preferred method of treating flaccid bladder/failure to store?
intermittenct catheterization
What maneuver is helpful with LMN flaccid bladder?
valsalva
What medicine stimulates cholinergic receptors in the urinary system? What does it help accomplish?
bethanocol/voiding
Name 4 drugs that block alpha-1 adrenergic receptors (thus promoting relaxation at the base of the bladder and voiding)
alpha-1 blockers:
minipress
dibenzyline
hytrin
cardura
The basic functional problem of an UMN bladder is what?
failure to store
What are the two direct causes of a UMN failure to store bladder?
incompetent sphinter
spastic bladder
What neurological disease classically results in a spastic detrusor?
MS
What event in SCI is a cause of failure to store?
return of urinary reflex arc after spinal shock
What type of brain injury results in a spastic detrusor?
subacute CVA
Where is the lesion causing an UMN bladder?
above the sacral micturation center at S2
What 3 classes of meds promote storage in a UMN failure to store bladder?
alpha adrenergic agonist
direct smooth muscle relaxant
anticholinergic
What class of med is most commonly used to promote storage in an UMN failure to store bladder?
anticholinergic
What are two example of anticholinergic meds used to treat failure to store?
detrol
pro-banthine
What reflex is absent in LMN failure to empty bladder?
bulbocavernosus
In a LMN failure to empty bladder what happens to detrusor pressure as the bladder fills?
remains constant
What is the appearance of a LMN failure to empty bladder EMG of the pelvic floor?
flat line
In a UMN failure to store bladder there is or there is not suppression of the sacral micturation center?
there is no suppression of the sacral micturation center and the bladder fails to store urine and the patient voids prematurely
What is represented by the first burst of activity in a failure to store UMN bladder EMG of the pelvic floor?
bulbocavernosus reflex
In a UMN failure to store bladder EMG of the pelvic floor, what is the EMG activity during micturation and what sphincter does this represent?
silence/external urethral sphincter
Up to 85% of SCI develop what type of bladder condition?
detrussor sphincter dyssynergia
Between what two structures is the injury causing detrussor sphincter dyssynergia (DSD)?
Between the sacral micturation center S2-S4 and the pontine micturation center
What 3 conditions can lead to DSD?
MS
Central cord syndrome
progression of SCI
What is the practical result of DSD?
failure to empty (similar to LMN bladder)
What is the tone of the detrussor and sphincter in DSD?
both spastic
What are the voiding pressures in DSD, high or low?
high
What is a complication of DSD?
vesicoureteral reflux
In DSD volumes are increased or decreased?
volumes are increased in DSD
What is the treatment of DSD?
anticholinergic meds such as detrol and pro-banthine
Why treat DSD with anticholinergics?
anticholinergics promote bladder wall relaxation and help prevent vesicoureteral reflux
What other class of meds is used to treat DSD?
alpha-1 adrenergic blockers
What two classes of meds is used to treat combination bladder (detrussor sphincter dyssynergia)? function of each
anticholinergics- relax detrussor
alpha-1 adrenergic blocker- relax sphincter
What is a surgical treament for DSD?
sphincterotomy
Is the the vesicoureteral valve one-way or two-way?
one way
What is the activity of pelvic floor muscles during urination of a patient with DSD? high or low
high electrical activity
What is the normal EMG activity of pelvic floor muscles during micturation?
silent
During voluntary inhibition of micturation what is the activity of EMG of pelvic floor muscles?
high
What is the normal vesicoureteral angle description?
oblique
With bladder wall hypertrophy the normal oblique vesicoureteral angle becomes increasingly what angle?
perpindicular
A perpindicular vesicoureteral angle renders the valve incompentent true/false?
true
What happens when the vesicoureteral valve is incompetent?
the valve cannot close during bladder contraction so urine is forced up the ureters to the kidneys resulting in hydronephrosis
Acidic or basic urine inhibits microbial growth?
acidic urine inhibits microbial growth
Is assymptomatic bacteruria in an indwelling catherter SCI patient treated?
no
Name 3 urine acidifying agents used in SCI prophylactically?
vit C
cranberry juice
methenamine
What SCI patients should not have their urine acidified prophylactically?
vesicoureteral reflux
pre-cystocopy or urodynamic procedures
urease-producing organisms
Name 6 urease producing organisms?
klebsiella
pseudomonas
proteus
providentia
e.coli
staph epidermidis
Abx treatment is started when clean catch specimen show what level of infection(organisms/ml)?
100,000/ml
Abx treatment is started when a urine cath shows what level of infection (organisms/ml)
100/ml
What are 4 signs that indicate a UTI should be treated?
pyuria
fever
spasticity
neurogenic pain
What are the most common earliest changes in a neurogenic bladder?
irregular, thickened bladder wall
small diverticuli
What are two serious complications of vesicoureteral reflux?
pyelonephritis
renal stones
What is another common urinary complication of a neurogenic bladder?
vesicoureteral reflux
Below what pressure (cm/H2O) is best for draining the neurogenic bladder to help prevent complications?
below 40cm/H2O
Ejaculation is under the control of the sympathetic or parasympathetic system?
sympathetic
What peripheral nerve manages erections?
pudendal
What is the spinal level and spinal structure involved in the erection reflex arc?
S2-4/cauda equina
Pre- or post-ganglionic parasympathetic fibers secrete nitric acid?
post-ganglionic
In creating an erection what do post-ganglionic parsympathetic fibers secrete?
nitric acid
What are the two vascular functions of nitric acid?
*relaxes corpus cavernosum
*increases blood flow to penile arteries
What spinal levels are involved in ejaculation?
T11-L2
Through what nerve plexus do the T11-L2 sympathetic fibers controlling ejaculation travel?
hypogastric plexus
What are the 3 structures innervated by T11-L2 sympathetic fibers controlling ejaculation?
vas deferens
seminal vesical
ejaculatory ducts
What percentage of men with complete and incomplete UMN lesions can get reflexogenic erections?
>90%
What is more likely, an erection with UMN or LMN injury?
UMN
What percentage of men with complete LMN can achieve erection?
12%
What percentage of men with incomplete UMN lesions can get erections?
50%
Are erections possible with complete UMN lesions?
no
What percentage of men with complete LMN lesions can get erections?
25%
What spinal levels mediate a reflexogenic erection?
S2-4
Are erections more likely with complete or incomplete lesions?
incomplete
What class of meds induce erections?
phosphodiesterases
What are two available phosphodiesterases?
sildenafil
vardenafil
A patient with what type of lesion responds best to phosphodiesterases? UMN or LMN injury
UMN
What prostaglandin can be used for intracorporeal injections?
prostaglandin E1
What 3 classes of meds can be used for intracorporeal injections?
prostaglandins
alpha blockers
vasodilators
What is a risk of intracorporeal injections?
priapism
What percentage of men with complete UMN lesions can ejaculate?
5%
What percentage of men with complete LMN lesions can ejaculate?
18%
What percentage of SCI couples with have successful reproduction?
<10%
What is a complication of penile vibratory stimulation?
AD
What are three sperm retrieval methods in SCI?
penile vibratory stimulation
electroejaculation
testicular extraction
Electroejaculation can improve the quality of what fluid?
semen
Prostatic fluid stasis promotes what quality measure of semen?
motility
Sitting with legs together in SCI promotes what thermal condition that decreases the quality of semen?
testicular hyperthermia
Leukocytes in the semen reduce what three semen metrics?
motility
total count
velocity
What is the predictive factor for inability of sperm to penetrate ovum?
leukocyte concentration
What is the most common biopsy finding of SCI testicles?
atrophy of seminiferous tubules
Stimulation afferents of female genitalia is carried by what nerve and mediated at what spinal level?
pudendal nerve/S2-4
In a female the efferent parasympathetic fibers invovled with sexual excitation are carried in what nerve?
pelvic nerve
Amenorrhea occurs in what percentage of women with a cervical or high thoracic SCI immediately after injury?
85%
Amenorrhea occurs in what percentage of SCI women overall?
50%
What percentage of high thoracic or cervical SCI experience a return of menses and in what time frame range?
50%/6-12 months
What percentage of overall SCI women have a return of menses within 6-12 months?
90%
Does SCI affect female fertility?
No
What is an SCI risk factor of an IUD?
pelvic inflamatory disease - AD
Is the likelihood pregnancy changed with SCI vs normal
no
What is a respiratory complication of SCI pregnancy?
decreased pulmonary function
What is a general SCI complication of pregnancy?
AD
What may be the only sign of SCI labor?
AD
What is the spinal innervation range for the uterus?
T10-T12
How long should the epidural remain in place after SCI delivery in order to reduce likelihood of AD?
12 hours
What are the two plexi of the enteric nervous system?
Auerbach's and Meissner's plexi
Where do Meissner;s and Auerbach's plexi lay?
between the two layers of the gut smooth muscle
Is Auerbach's primarily motor or sensory?
motor
Is Meissner's primarily motor or sensory?
sensory
What part of the colon does the vagus nerve innervate?
proximal to mid transverse colon
The splanchnic or pelvic nerves innervate what part of the colon?
decending colon and rectal region
What is the spinal level range origin of the splanchnic or pelvic nerve?
S2-4
The splanchnic and vagus nerves are part of what nervous system?
parasympathetic
What is the function of the sympathetics on colonic motility?
decreases colonic motility
What nerve serves the sympathetic nervous system in the gut?
hypogastric
The hypogastric nerve sympathetic fibers are distributted in the gut by what 3 ganglia?
superior mesenteric
inferior mesenteric
celiac
Is the external anal sphincter smooth or striated?
striated
What spinal level range controls the internal anal sphincter?
T11-L2
What type of muscle is the internal anal sphincter, smooth or striated?
smooth
What nerve innervates the external anal sphincter? What spinal level range?
pudendal nerve/S2-4
The internal anal sphincter relaxes or constricts with the filling of the rectum?
relaxes
What is the brain defecation center?
pontine defecation center
What causes reflex internal anal sphincter relaxation?
rectosigmoid distension
Volitional contraction of what muscle allows the opening of the proximal rectal canal?
levator ani
The levator ani muscle action to open the canal relaxes what two other striated muscles thus allowing defecation?
external anal sphincter
puborectalis muscle
An UMN lesion results in a hyper or hyporeflexic bowel?
hyperreflexic bowel
In a UMN, hyperreflexic bowel, there is no volitional control to relax what sphincter?
External anal sphincter
An UMN lesion results in a reduced ability to sense the urge to defecate, true or false?
true
How are stools propelled in UMN lesion?
reflex activity
A LMN lesion is one that is below what spinal structure?
conus medullaris
A LMN bowel is one that is hyper, hypo, or a- reflexic?
areflexic
What bowel function is absent in a LMN or a-reflexic bowel?
reflex defecation
What plexus coordinates movement of stool in the colon?
Auerbach's or myenteric plexus
What is the practical outcome of a LMN or areflexic bowel?
constipation with incontinence due to a flaccid external anal sphincter
What is the tone of a LMN bowel external anal sphincter?
flaccid tone
What are the two most common complications of a UMN bowel lacking parasympathetic and sympathetic control?
constipation
fecal impaction
Constipation and fecal impaction are two complications of what type of lesion? UMN or LMN
UMN
Constipation and fecal impaction are two complications of UMN lesion lacking parasympathetic and sympathetic input at what 2 sections of the colon?
transverse and descending colon
When does post-injury ileus resolve
1 week
What device has been show to effective in promoting peristalsis?
TENS
In SCI what agent is used for refractory pseudo-obstruction?
neostigmine
What two agents can promote peristalsis post-injury?
metoclopromide
erthythromycin
What device should be inserted immediately upon SCI and why?
NG tube and suction to prevent GI dilation
Surgery or colonoscopy may be indicated if cecum is distended more than how many inches?
>12"
What 3 classes of med that slow bowel motility should be avoided in SCI with bowel dysfunction?
anticholinergics
opioids
tricyclics
Bulk-forming agents are more commonly used initially in UMN or LMN lesions?
LMN lesions
How do bulk forming agents promote evacuation?
by retaining or pulling H2O into the colon
What two substances accumulate in the colon with the use of stool softeners such as docusate sodium?
fat and fluid
On what nerve structure does senna (oral stimulant) act and for what effect?
stimulates peristalsis by acting on Auerbach's plexus
What are two ways that glycerine suppositories work?
draws water into stool and stretches rectal wall
In what two ways do bisacodyl (Dulcolax) suppositories work?
stimulates peristalsis
stimulates sensory nerve
What two intact reflexes are used to create a bowel program?
gastrocolic reflex
anorectal reflex
What is the gastrocolic reflex?
increased colonic activity 30-60 minutes after a meal
What is the anorectal reflex?
relaxation of the internal anal sphincter when bowel contents stretch the bowel wall reflexively.
How is the anorectal reflex leverage in a bowel program?
Suppositories and digital stim cause bowel wall to stretch, thereby, through the anorectal reflex, relaxing the internal anal sphincter.
In what direction, clockwise or counterclockwise, digital stim done to promote the anorectal reflex?
clockwise
What topical should be used during fecal disimpaction and why?
lidocaine gel/to reduce likelihood of AD
What type of meds are used for failure to store bladder (UMN) that may cause constipation?
anti-cholinergics
What agent is used short term for GERD in SCI?
metoclopramide
When (early or late) after injury is GI bleeding most likely to occur?
early
How does sucralfate work?
promotes local prostaglandin synthesis
What is the most common cause of emergency abdominal surgery in SCI?
cholecystitis
Gallbladder dysfunction is more common in SCI with a lesion above what level?
T10
During what month post SCI is pancreatitis common?
first month post injury
What two conditions may be suspected if adynamic ileus does not improve in the normal time frame?
cholecystitis
pancreatitis
What two blood labs are elevated in pancreatisis?
lipase
amylase
What is superior mesenteric artery syndrome?
third portion of duodenum is compressed by the superior mesenteric artery resulting in GI obstruction
What are 4 risk factors for SMA syndrome?
supine
rapid weight loss
spinal orthosis
flaccid abdominal causing spinal hyperextension
What are 3 cardinal symptoms of SMA syndrome?
postprandial nausea
bloating
abdominal pain
An upper GI series study showing abrupt duodenal obstruction is diagnostic for what SCI complication?
Superior mesenteric artery syndrome
What are three treatments for superior mesenteric artery syndrome?
small frequent meals
left lateral decubitus after meals
metoclopramide
What is the function of metoclopramide?
Stimulates GI motility
In general what factor promote development of superior mesenteric arthery syndrome?
any force (weight loss, supine, flaccid abdominals, spinal orthosis) that reduces the angle between the SMA and the aorta
What sided renal vein abuts the 3rd part of the duodenum?
left renal vein
What is a common metabolic condition in SCI resulting from immobilization?
hypercalciuria
Are Vit D and parathyroid hormone involved with hypercalciuria?
no
When the efflux of calcium coming out of bones is massive or the glomular filtration rate of the kidneys is reduced, what can result?
hypercalcemia
Hypercalcemia is more common in tetra or paraplegia?
tetraplegia
What is the percentage range of SCI with hypercalcemia?
10-23%
In what week range after injury does hypercalemia occur?
4-8 weeks
What is the normal level of serum calcium?
<10.5
For what must the serum calcium be corrected?
albumin, since serum calcium is protein bound
What can prolonged hypercalcemia cause?
nephrocalcinosis
What is the treatment for hypercalcemia?
IV normal saline
What is the function of IV normal calcium in the treatment of hypercalcemia?
increases urinary excretion of calcium
What is an activity treatmen for hypercalcemia?
early mobilization, standing, and ambulation as tolerated
Is dietary restriction of calcium indicated in hypercalcemia?
no
What type of Vit D level is low in hypercalemia?
1,25-dihydroxyvitamin D
Low 1,25 hydroxyvit D suppresses intestinal absorption of what molecule?
calcium
In hypercalcemia, what vitamin intake is restricted?
Vit C
What is the medication rx for hypercalcemia?
pamidronate
What are the two mechanisms of action of pamindronate?
inhibits osteoclast resorption
reduces osteoclast viability
How is pamidronate administered?
one IV infusion
How quickly does pamidronate reduce serum calcium levels?
within 3 days
When (in days) following pamidronate infusion does serum calcium reach its nadir?
within 7 days
What med should not be used in hypercalceima since it can cause hypercalcemia?
thiazide diuretics
What other meds may be used to treat hypercalcemia?
didronel
calcitonin
Where does osteoporosis occur in SCI?
below the level of the lesion
What percentage of bone is lost within 3 months of SCI?
22%
What is the incidence of long bone fracture in SCI?
2.5% over 20 years
In what type of injury are long bone fractures more common complete/incomplete; tetra/para
complete para
What is the most common cause of fracture in SCI?
falls during transfers
What is the most common site of fracture in SCI? Second most common
most common:supracondylar femur fractures
second most common: proximal tibia
What 3 fracture treatment techniques in normals are not indicated in SCI?
surgery, circumferential casting, and external fixation
What are the most difficult SCI fractures to manage?
femoral neck and subtrochanteric
What percentage of SCI show insulin resistence?
70%
What percentage of SCI have respiratory complications in the first month post-injury?
67%
At what spinal level range are respiratory complications most common
C1-4
What are the three most common SCI complications?
pneumonia
atelectasis
ventilatory failure
What level SCI has respiratory failure due to diaphragmatic innervation interruption?
C3
The innervation of what respiratory muscle is interrupted in a C3 injury?
diaphragm
What is the highest C level SCI able to maintain spontaneous ventilation?
C4
Above hat level SCI is there a loss of all abdominal and intercostal power?
above C8
Intercostal volitional function is lost at what SCI level range?
T1-5
In what SCI level range is there a loss of forceful expiration or cough?
T5-12
What is the respiratory loss in SCI T5-T12?
loss of forceful expiration and cough
What is the leading cause of death in chronic SCI?
pneumonia
Name 3 predisposing factors for SCI pulmonary complication?
older
obesity
hx of lung disease, smoking
What side of lung are SCI respiratory complications usually located? Why?
left side - main bronchus branches off at 40 degrees making it more difficult to clear secretions, especially with suctioning
Above what SCI level intially requires ventilatory support?
above C3
What is the cervical level range of innervation to the diaphragm? Name of nerve
C3 C4 C5/phrenic
What test determines damage to the phrenic nerve?
EMG of diaphragm or NCS of the phrenic nerve
What are the two criteria determining candidacy for phrenic nerve pacing?
phrenic nuclei intact
UMN
What is the only test to determine damage to the phrenic nucleus?
EMG of the diaphragm
What are three contraindications to phrenic pacing?
*denervated diaphragm
*placement prior to 6 months post injury
*lung impairment
Do SCI patients with phrenic pacing survive longer?
yes
What respiratory metric increases with phrenic pacing?
arterial oxygenation despite decreased alveolar ventilation
What is respiratory metric is decreased with phrenic pacing?
alveoloar ventilation
What are 5 signs of phrenic pacemaker failure?
sharp chest pain
shortness of breath
erratic pacing
What are 5 causes of phrenic pacemaker failure?
*diaphragmatic failure
*infection of lung or phrenic nerve
*meds (sedative, tranquilizers)
*upper airway obstruction
*phrenic nerve damage
During quiet breathing the diaphragm is responsible for what % of lung volume change?
75%
Name 3 inspiratory muscles.
diaphragm
external intercostals
accessory muscles
What muscle contracts during inspiration?
diaphragm
What muscle relaxes during expiration?
diaphragm
Name 2 expiratory muscles.
internal intercostals
abdominals
What respiratory metric decreases during acute cervical SCI?
FVC
Why does the forced vital capacity decrease 25-30% during an acute cervical SCI?
paradoxical respirations
In a cervical SCI what causes the FVC to increase to 50-60% of predicted normal value?
intercostal and abdominal spasticy
What is the lung pattern of tetraplegics?
restrictive lung pattern
What is the only lung volume that does not decrease in cervical SCIs?
residual volume
At what VC is mechanical ventilation considered?
VC<1 L
At what cc/kg range can a SCI patient be weaned off a ventilator?
15-20cc/kg
Compared to a normal, a cervical SCI with phrenic nerve injury has lung movements that change in what 2 pathological ways during inspiration?
diaphragm move up
abdominal wall moves in
During inspiration a diaphragm that move up and an abdominal wall that move in indicates damage to what structure?
phrenic nerve
In inspiration with an injured phrenic nerve, what is the movement of the chest wall (in or out); what is the movement of the diaphragm (up or down); and what is the movement of the abdominal wall (in or out)
chest wall - out
diaphragm - up
abdominal wall - in
Increased respiratory rate with decreased tidal volume is an indicator of what pending incident?
respiratory failure
Inability to count to 15 slowly is indicator of what impending event?
respiratory failure
Respiratory failure is evident at what cervcial SCI level?
C3
Respiratory failure is evident at what FVC cc/kg body weight?
<15 cc/kg body weight
What are 4 indicators of impending respiratory failure?
*can't count to 15 slowly
*FVC< 15 cc/kg body weight
*C3 or higher SCI
*increased respiratory rate with decreased tidal volume
What are 5 indicators to initiate mechanical respiration?
VC<1 liter
ABG shows decreasing PCO2 or decreaseing PO2
PO2<50
PCO2>50
severe atelectasis
Decreasing PO2 or increasing PCO2 are indicators to do what?
mechanical venilation
PO2<50 or PCO2>50 are indicators to initiate what?
mechanical ventilation
VC<1L is an indicator to do what?
mechanically ventilate
Severe atelectasis in an SCI patient is an indication to do what?
mechanically ventilate
What are two advantages of a mechanical cough device over a manual cough assist?
*clears secretions better
*clears larger mucous plugs better
What are two contraindications to a mechanical cough device?
bullous emphysema
susceptibility to pneumothorax
Strengthening of what muscle can assist in preventing respiratory complications?
pectoralis major - clavicular portion
Training in what type of breathing can help prevent respiratory complications?
glossopharyngeal breathing
What is the percentage range of sleep apnea in SCI?
15-60%
What is the most common type of sleep apnea in SCI?
obstructive
There is an increased risk for what 5 conditions with SCI obstructive sleep apnea?
hypertension
pulmonary hypertension
CHF
depression
death
What is the incidence range of HO in SCI?
15-60%
What type of bone is HO?
mature lamellar bone - indistinguishable from normal bone
Does HO occur above or below level of injury?
below
In order of incidence what are the 4 most common joints affected by HO?
hip/knee/shoulder/elbow
What month range post injury is HO most common?
1-4 months
What are 5 signs/symtoms of HO?
fever
edema
erythema
decreased ROM
heat
What is 5 risk factors for HO?
spasticity
pressure ulcer
completeness of injury
younger age
prior surgery to joint
What study is positive for HO earlier, bone scan or xray
bone scan
What is the day range after clinical signs/symptoms of HO appear that xray findings are positive?
7-10 days
In HO when does serum alk phos first rise and peaks, in weeks?
first rises - 2 weeks
peaks - 10 weeks
What 3 blood tests are elevated in HO not specific for HO?
alk phos
CPK
ESR
What are 3 complications of HO?
peripheral nerve entrapment
loss of ROM
pressure ulcer
What is a medication prophylaxsis for HO?
etidronate disodium
For what period of time should etidronate disodium be prescribed when used as a treatment for HO?
6 months
What is the HO treatment dose of etidronate disodium with normal CPK?
20mg/kg/day x 3 months then 10mg/kg/day for 3 months
What is the HO treatment dose of etidronate disodium with elevated CPK?
20mg/kg/day for 6 months
What is an indocin dose for the treatment of HO?
indocin SR 75mg/day for 6 weeks
What anti-coagulant is used to treat HO?
warfarin
What are the two functions of radiation therapy in HO?
prevents further HO formation
prevents recurrence after surgery
When (months post-inury) should surgery be done for HO?
12-18 months post-injury
What must the status of the bone scan be for surgical treatment of HO?
normal bone scan
What is Virchow's triad?
venous stasis
intimal injury
hypercoaguability
What are 0 predisposing factors for DVT in SCI?
Virchow's triad (venous stasis, intimal injury, hypercoagulability)
LE fractures
obesity
previous DVT
DM
PVD
older
immobility
malignancy
What is the percentage range of DVT in SCI?
47-100%
What are specific SCI risk factors for DVT?
complete injury
tetraplegic
plegic leg
How many more times common is DVT in plegic leg than not?
10x more common in plegic leg
When (weeks post-injury) is DVT most common is SCI?
first 2 weeks post-injury
When (week range post-injury)does the incidence of DVT in SCI decrease?
8-12 post SCI
What is gold-standard study for DVT?
venogram
Impedence plethysmography is good at detecting DVTs located where? What is the sensitivity/specificity?
above calf
sensitivity: 95%
specificity: 98%
What is the leading cause of death in acute SCI?
Pulmonary embolism
In PE what heart sound is increased?
S2
What side of the heart fails in PE?
right side
What is the incidence of PE in acute/subacute SCI?
7%
Is PE influenced by the degree of level of SCI?
no
What is an EKG finding in PE?
right axis deviation
What is the EKG finding in a massive PE?
right bundle branch block
What are 3 chest xray findings of PE?
*wedge shaped opacity
*vascularity
*fluid
What is the gold standard test for PE?
pulmonary arteriogram
What med is used to treat the shock of PE?
vasopressin
What are 6 symptoms of PE?
Pleuritic chest pain
dyspnea
tachycardia
fever
hemoptysis
hypoxemia
What are 3 acute treatments for PE?
02
heparin
vasopressin
What is the surgical treatment for PE?
embolectomy
What 3 metrics are improved by external mechanical compression?
reduced stasis
improved fibrinolysis
improved venous return
Ruling out a DVT must be done if compression devices are not applied within how long (hours) of SCI injury?
>72hours
What low weight molecular heparin is used for DVT prevention, and at what dose?
enoxaparin 30mg sq BID
What is the typical dose of unfractionated heparin in SCI DVT prevention?
5000 u BID
When using adjusted dose unfractionated heparin, what should PTT be in relation to control (xcontrol).
1.5x control
What is a SCI-specific indication for IVC filter?
high level complete tetra with poor cardiopulmonary reserve
Until what hospitalization milestone should DVT prophylaxis continue in incomplete SCI?
discharge from hospital
Until when (in weeks post injury) should DVT prophylaxis be continued in an uncomplicated complete motor SCI?
8 weeks post injury
Until when (in weeks post-injury or what hospitalization) should DVT prophylaxis be continued in SCI patients with complete motor AND other risk factors?
12 weeks post injury or discharge from rehab
What device is not a substitute for prophylaxis?
IVC filter
What is the heparin dose to treat DVT?
5000 units IV bolus then 1000 u/hr
What is the preparation of constant 1000 u/hour infusion heparin for DVT treatment?
25,000 units heparin in 250 mL D5W at 10cc/hour
At what level in relation to control (xcontrol) should the PTT be maintained for heparin treatment of DVT?
1.5-2 x control
How long should coumadin be maintained after heparin treatment in documented proximal DVT?
6 months
How long is IV heparin maintained in acute DVT treatment?
5-10 days
What technique can be used in SCI for cardiovascular conditioning?
functional electrical stimulation
Functional electrical stim in SCI increases what three muscle metrics?
increases muscle mass, bulk, and endurance
What are two general uses of functional electrical stim?
*avoid complications of muscle inactivity
*produce extremity motion for functional activities
What percentage range of SCI patients are functionally disabled by pain?
18-44%
What two pain scales are used in SCI?
bryce ragnarsson
IASP
The IASP and bryce ragnarsson scales classify pain based on what two characteristics?
location
clinical presentation
What joint is the most common location for pain in chronic SCI?
shoulder
Is pain more common in tetra or para SCIs?
tetra
Use of what device is associated with shoulder pain in SCI?
wheelchair use
Shoulder pain in SCI is associated with what ADL?
transfers
Physical therapy in SCI shoulder pain is focused on stretching what muscles shoulder and strengthening what shoulder muscles?
*stretching anterior shouler muscles
*strengthening posterior muscles
What shoulder muscles become hypertrophied and contracted due to wheelchair use?
external rotators
What is the percentage range of neuropathic pain in SCI?
60-70%
Is there a severity or SCI level correlation with neuropathic pain?
no
What are the two peak age range groups for neuropathic pain?
30-39 and >50 years old
What fraction of SCI develop UE compression neuropathies?
2/3rds
What are the most common SCI neuropathies?
median and ulnar
Ulnar and median neuropathies are more common in tetras or paras?
paras
What is the incidence percentage range of carpal tunnel syndrome in SCI paras?
21-65%
What is the incidence percentage of bilateral UE nerve compression in SCI?
25%
What is the most common cause of progressive myelopathy after SCI?
syringomyelia
What phenomenon occurs in the spinal cord at the level of injury?
cavitation
What is the direction (caudal or cephalad) of the post-inury spinal cord cavitation?
cephalad
What percentage of SCI develops syringomyelia?
8%
What is the time frame (in months post-injury) that syringomyelia develops?
2 months
What imaging study first detects syringomyelia?
MRI
In what matter (gray or white) does the syrinx develop?
gray
Where in the spinal cord does the syrinx develop?
in the gray matter between the dorsal horns and posterior columns
What is the most common sign of syringomyelia? What type of activity provokes the symtoms?
pain/cough, sneezing, strain, etc.
Coughing or straining in what position provokes syringomyelia pain?
sitting
What is the earliest sign of of syringomyelia? Second earliest?
loss of DTRs/ascending sensory level loss
What is the gold-standard imaging study for syringomyelia?
MRI with gadolinium
Name 7 signs/symptoms that may indicate syringomyelia?
*more or less spasticity
*AD
*loss of reflex bladder
*worsening OH
*new Horner's syndrome
*reduced respiratory drive
*diaphragmatic paralysis
*cranial nerve dysfunction
What is the general activity restriction in those with syringomyelia?
avoid activities that increase intra-thoracic/abdominal pressure
What are two indications for surgery in syringomyelia?
progressive neurological loss
intractable pain
What percentage of SCI patients with treated syringomyelia experience recurrence of symptoms?
50%
What two conditions in SCI result from arthropathy of joints with impaired pain and proprioception?
charcot joints
charcot spine
What is the goal of surgical interventions in tetraplegics to improve functional mobility?
to improve motor function by 1 level
When post-injury (months) are surgical interventional commenced?
12 months
What does the grade of 0-Cu predict?
sufficient proprioception to allow hand function without visual cues
Muscles being transferred generally lose how much strength?
loss of 1 grade of strenght i.e. 4 to 3
What are the muscles and direction of tendon transfer for a C5 quad?
brachioradialis to ECRB
A C5 quad who shows improved lifting of objects, feeding and grooming, and hygeine tasks indicates what type of tendon transfer has taken place?
brachioradialis to ECRB
A deltoid to triceps tendon transfer is performed on what level quad?
C5
What function does a brachioradialis to ECRB transfer improve?
wrist extension
What function does a deltoid to triceps transfer provide?
elbow extension
What 8 functions does a deltoid to triceps transfer improve?
stabilize sitting
stabilize transfer
reach overhead against gravity
grooming
hygeine
pressure relief
writing speed
feeding
Stabilize sitting,stabilize transfer, reach overhead against gravity, grooming, hygeine, pressure relief, writing speed, and feeding are all improved in what level quad with what tendon transfer?
C5 with a deltoid to triceps transfer
What level SCI undergoes a Moberg key grip procedure?
C6
What 4 functions are improved with a Moberg key grip procedure?
grooming
eating
writing
desktop skills
What level SCI undergoes a brachioradialis to flexor pollicus longus transfer?
C6
What procedure in a C6 is preferable to a Moberg key grip procedure?
brachioradialis to flexor pollicus longus
What procedure restores a lateral pinch, in what SCI level?
brachioradialis to flexor pollicus longus/C6
A posterior deltoid to triceps transfer is done in what SCI level?
C6
What procedure in a C6 is done prior to hand reconstruction?
posterior deltoid to flexor pollicus longus
Rerouting of biceps around radial neck is done for what SCI level?
C6
What procedure corrects supination contracture of forearm? for what SCI levels is it done?
rerouting of biceps around radial neck/C5 or C6
What procedure is done to restore thumb flexion? for what level SCI?
brachioradialis to flexor pollicus longus
C7
What procedure is done to restore finger flexion? for what level SCI?
extensor carpi radialis longus (ECRL) or flexor carpi ulnaris (FCU) TO flexor digitalis profundus (FDP)
C7
What level SCI is appropriate for restoration of thumb and finger flexion?
C7
What device is used in a C8 to improve a claw hand?
lumbrical bar
What does a lumbrical bar do? In what SCI level is it used?
prevents hyperextension of MCPs/ C8
How long (range of months) are the tendon transfered extremities immobilized?
1-3 months
What two techniques are used in tendon transfer rehab?
biofeedback
electrical stimulation
Neuroprosthesis device is appropriate for what level SCI?
C5 or C6 tetras
How does a neuroprosthesis function?
movement of contralateral shoulder activates opposite hand grasp
Spasticity appears as what post-injury phenomenon resolves?
spinal shock
What appears when spinal shock resolves?
spasticity
What is the incidence percentage range of concomitant TBI and SCI?
25-60%
What are 5 risk factors for TBI with SCI?
*mechanism of injury
*loss of conciousness
*higher neurologic level
*post-traumatic amnesia
*initial Glasgow Coma Scale
A "sympathetic storm" in a patient with TBI and SCI is often heralded by what phenomenon?
transient elevation of blood pressure
When does depression usually occur in SCI (month post-injury)?
within first month post-injury
What percentage range of SCI patients experience depression?
20-45%
How many times greater is the SCI suicide rate accounting for age and gender?
5x
During what year range post-injury is suicide most common?
1-5 years
In what type of SCI is suicide higher, complete or incomplete?
incomplete
In what SCI age group is suicide the highest?
youngest age group
What is the rate (percentage) of PTSD in SCI?
20%
What are two risk factors for PTSD in SCI?
anxiety
depression
Substance abuse in SCI increases what behaviour while intoxicated?
risk taking
What percentage of acute/chronic SCI develop pressure ulcers?
acute: 25%
chronic: 80%
What is the second most common etilogy for rehospitalization in SCI?
skin issues
A full thickness tissue loss with exposesd bone, tendon, or muscle is what stage ulcer?
Stage IV
What is a stage IV ulcer?
full thickness tissue loss with exposed bone, tendon, or muscle
A non-blanchable erythema of a localized area usually over a bony prominence is what stage ulcer?
Stage 1
What is a stage I ulcer?
non-blanchable area of erythema over a bony prominence
What is a stage II ulcer?
partial thickness loss of dermis or dry shallow ulcer
A partial thickness loss of dermis or a dry shallow ulcer is what stage ulcer?
Stage II
What is a stage III ulcer?
full-thickness destruction through dermis into subcutaneous tissue. Fat may be visible, but bone, tendon, or muscle are not exposed; may include tunneling
A full-thickness destruction through dermis into subcutaneous tissue. Fat may be visible, but bone, tendon, or muscle are not exposed; may include tunneling is what stage ulcer?
Stage III
In National Pressure Ulcer Advisory Panel terminology, what is a deep tissue injury?
purple area of discolored skin due to underlying soft tissue damage from pressure or shear, but the wound bed cannot be visualized
Where are the 4 most common pressure ulcers in the first two years of SCI?
sacrum
ischium
heels
trochanters
After what time frame (years after injury) does the most common site of ulcer change to ischial tuberosities?
after 2-years post injury
Where is the most common site of injury in SCI 2 years after injury?
ischial tuberosities
In children up to 13 where is the most common site of ulcer development?
occiput
What are the two most important risk factors for pressure ulcers?
pressure
shear
What are two SCI specific risk factors for pressure ulcers?
higher level of SCI
greater severity of SCI
What are 3 social risk factors for pressure ulcers in SCI?
non-employment
lower education
alcohol and tobacco use
What are 2 constitutional risk factors for pressure ulcers in SCI?
anemia
poor nutrition
Above what mmHg does soft tissue ischemia take place?
>70mmHg
How long and exceeding what pressure in mmHg does tissue ichemia take to occur when over a bony prominence?
2 hours; >70mmgHg
What is the supracapillary pressure?
>70mmHg
Pressure >70mmHg for over 2 hours results in what?
occlusion of dermis microvessels, causing tissue ischemia
What structure is more susceptible to tissue ischemia than skin?
muscle
What force removes the corpus striatum(stratum corneum) of skin?
shearing force
Friction or shearing forces remove what layer of skin?
corpus striatum or stratum corneum
Skin ischemia results is what in the surrounding tissues?
hyperemia
Shear mechanically separates what two skin layers?
separates the epidermis from the basal cells
How often should repositioning be done?
every 2 hours
During sitting how often should there be pressure relief?
every 20-30 minutes
What stage ulcers MAY require surgical debridement?
Stage III
What metabolic steriod is used in the treatment of pressure ulcers?
oxandrolone
Name two appetite stimulants used in SCI?
marinol
megace`
As the wound becomes cleaner, the strength of the cleaning solution should become stronger or weaker?
weaker
Below what pressure (psi) is used for pulsitile irrigation of pressure ulcers?
<15 psi
What type of dressing is used for heavy exudate ulcers?
calcium alginate
What 3 types of dressings are used for mild exudate ulcers?
hydrocolloid
polyurethane foam
saline gauze
What is the only recommended ulcer treatment modality?
electrical stimulation
Electrical stim for ulcer improves what three metrics?
circulation
granulation
decreased bacterial count
What are 3 contraindications to electrical stim in pressure ulcer treatment?
cellulitis
pacemaker
metal ions
What is the most common surgical intervention for pressure ulcers?
musculocutaneous flap (including muscle and blood vessels)
What is the shape of a rotation flap?
semi-circular
What is the shape of a transposition flap?
rectangular
What is the shape of the defect that a rotation flap fills?
triangular
Post flap, what is the initial period of strict bed rest (week range)?
3-4 weeks
Post flap surgery, what is the starting period (minutes) for sitting after the 4 week period of strict bed rest?
15 minutes daily and increase by 15 minutes BID