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10 Cards in this Set
- Front
- Back
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Jaundice: Hemolytic |
⬆️destruction of RBC
⬆️free bilirubin in plasma ⬆️production of bilirubin |
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de novo pathway to IMP (inosine 5' monophosphate) |
1.phosphoribosylpyrophosphate(PRPP) is synthesized from ribose-5phosphate
2. 6 mole eq of ATP used per mole IMP made 3. formation of phosphoribosylamine is committed step (first step) 4. TEtrahydrofolate serves a "C1" carrier 5. N-C bond of 5-phosphoribosylamine will be N-glycosidic bond of purine |
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Pyrimidines |
1. Uracil = 2,4-dioxy pyrimidine 2. Thymine = 2,4-dioxy-5-methyl pyrimidine 3.Cytosine = 2-oxy-4-amino pyrimidine 4. Orotic acid = 2,4-dioxy-6-carboxy pyrimidine |
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Purines |
1. Adenine = 6-amino purine 2. Guanine = 2-amino-6-oxy purine 3. Hypoxanthine = 6-oxy purine 4. Xanthine = 2,6-dioxy purine |
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de novo synthesis regulation |
1. Control of the synthesis as a whole occurs at the amidotransferase step by nucleotide inhibition and/or [PRPP]. 2 maintaining an appropriate balance (not equality) between ATP and GTP. edback inhibition also controls the branched portion as GMP inhibits the conversion of IMP to XMP and AMP inhibits the conversion of IMP to adenylosuccinate. |
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PRPP |
PRPP used for::Synof purines, Synof pyrimidines, Synof NAD , Salvage of nucleotide bases inhibited by::dinucleotides,ADP2,3-bisphosphoglycerateStimulated by Pi PRPP synthetase positive effector |
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Purine synthesis |
1.Formation of IMP 2.Conversion of IMP-----> GMP 3.Conversion of IMP-----> AMP |
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de novo purine synthesis enzymes for IMP |
1. glutamine PRPP amdotransferase; 2. GAR synthetase; 3. GAR transformylase; 4. FGAM synthetase; 5. AIR synthetase; 6. AIR carboxylase; 7. SAICAR synthetase; 8. adenylosuccinate lyase; 9. AICAR tranformylase; 10. IMP cyclohydrolase |
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IMP to GMP |
IMP dh is the rate determining enzyme and is regulated by GMP acting as a competitive inhibitor |
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IMP to AMP |
adenylosuccinate synthetase is the rate limiting enzyme, AMP acts as a competitive inhibitor |
