Smooth Muscle Drugs

Front 1

Name an example of an amine ergot alkaloid.

Back 1

Ergonovine

Front 2

Name an example of a peptide ergot alkaloid. (due to the cyclic peptide chemistry linked to its tetracyclic core ring system

Back 2

Ergotamine

Front 3

What is the name of the drug which is a synthetic congener of ergonovine and is abuse?

Back 3

LSD (lysergic acid diethylamide)

Front 4

What produces ergot alkaloids in nature?

Back 4

Claviceps pupurae, a fungus that infects grain and damp conditions. In humans, ingestion of this is a source of ergot poisoning.

Front 5

What are the two ergot alkaloid drugs which may be isolated from Claviceps purpurae?

Back 5

Amine alkaloids and peptide alkaloids

Front 6

How do ergot alkaloids function?

Back 6

They may function as agonist, partial agonist, and antagonist at alpha adrengeric receptors and serotonin receptors (mainly 5-HT1A and 5-HT1D), both centrally and peripherally

Front 7

Which ergot alkaloid has dopaminergic effects in the CNS and also inhibit the release of prolactin from pituitary cells?

Back 7

Bromocriptine

Front 8

Which drug causes prolonged and potent constriction of blood vessels?

Back 8

Ergotamine

Front 9

Ergotamine and Ergonovine

Back 9

Are partial agonist at both alpha-adrenergic receptors and 5-HT2 receptors.

Front 10

Ergot alkaloids stimulate or relax uterine smooth muscle?

Back 10

stimulate

Front 11

At lower doses, ergot alkaloids produce?

Back 11

rhythmic contraction and relaxation of the uterus

Front 12

At higher doses, ergot alkaloids cause

Back 12

forceful and prolonged contraction

Front 13

Which ergot alkaloid is the most selective for stimulation of uterine smooth muscle?

Back 13

Ergonovine