Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/13

Click to flip

13 Cards in this Set

  • Front
  • Back
Name an example of an amine ergot alkaloid.
Ergonovine
Name an example of a peptide ergot alkaloid. (due to the cyclic peptide chemistry linked to its tetracyclic core ring system
Ergotamine
What is the name of the drug which is a synthetic congener of ergonovine and is abuse?
LSD (lysergic acid diethylamide)
What produces ergot alkaloids in nature?
Claviceps pupurae, a fungus that infects grain and damp conditions. In humans, ingestion of this is a source of ergot poisoning.
What are the two ergot alkaloid drugs which may be isolated from Claviceps purpurae?
Amine alkaloids and peptide alkaloids
How do ergot alkaloids function?
They may function as agonist, partial agonist, and antagonist at alpha adrengeric receptors and serotonin receptors (mainly 5-HT1A and 5-HT1D), both centrally and peripherally
Which ergot alkaloid has dopaminergic effects in the CNS and also inhibit the release of prolactin from pituitary cells?
Bromocriptine
Which drug causes prolonged and potent constriction of blood vessels?
Ergotamine
Ergotamine and Ergonovine
Are partial agonist at both alpha-adrenergic receptors and 5-HT2 receptors.
Ergot alkaloids stimulate or relax uterine smooth muscle?
stimulate
At lower doses, ergot alkaloids produce?
rhythmic contraction and relaxation of the uterus
At higher doses, ergot alkaloids cause
forceful and prolonged contraction
Which ergot alkaloid is the most selective for stimulation of uterine smooth muscle?
Ergonovine