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26 Cards in this Set
- Front
- Back
- 3rd side (hint)
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History
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Ancient disease
scars on mummy of Ramses V fall of Aztec and Inca civilizations French-Indian War, intentional use of smallpox |
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History
Variolation |
pre-vaccination process may have began in Egypt
Lady Montague had son and daughter variolated Edward Jenner discovered vaccine |
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Epidemiology
pre-variolation/vaccination |
everyone got it and either died or lived with the scars
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Forms:
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Variola Major
Variola Minor |
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Variola Major
Variola Minor |
25-50% mortality (most common form - 90% of cases
1 % mortality |
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Epidemiology
Ever eradicated? |
Yes. 1980
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Etiology
family |
Poxviridae family
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Poxviridae family:
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Variola virus; an orthopoxvirus - enveloped DNA virus. Hardy virus, survives outside host longer than most viruses
Shaped like large brick |
Variola virus; an ____________ - ________ DNA virus. Hardy virus, survives ______ host longer than most viruses
Shaped like large ______ 200 NM diameter |
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Poxviridae family continued:
variola Major |
highly virulent; causes toxemia, shock, and hemmorhagic form
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Transmission
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Primarily through resp. droplets; fomites possible sources because of durability of virus
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transmission
also through |
bedding, clothing possible
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after infection...is one immune to the disease?
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Lifelong immunity usually results from surviving any form of the disease
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Pathogenesis
Step 1 |
Virus attaches to cells in mucous lining of nasopharaynx
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virus ______ to cells in ______ lining of ____________
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Pathogenesis
Step 2 |
Invades lymph nodes in area and multiplies there
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invades l_____ n_____ in area and __________ there
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Pathogenesis
Step 3 |
Invades blood and multiplies in white blood cells
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invades b---- and multiplies in ----- blood cells
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Pathogenesis
Step 4 |
Travels to small blood vessels to dermis of skin, clogging them, resulting in scar tissue and lack of pigment in those areas
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Travels to small blood v------ to dermis of skin, clo----- them, resulting in scar t----- and lack of pi----- in those areas
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Pathogenesis
Step 5 |
During prodrome, patient has high fever and fatigue
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during prodrome, patient has high _____ and _______
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Pathogenesis
Step 6 |
Lesions develop first in mouth and then other parts of body
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Lesions develop first in ______ and then other parts of ______
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Pathogenesis
Step 7 |
lesions open in mouth, virus comes out - patient highly contagious
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patient becomes highly contagious because
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Pathogenesis
Step 8 |
As rash develops on body, patient may have back and abdominal pain
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As ____ develops on body, patient may have ____ and a------- pain
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Pathogenesis
Step 9 |
Rash emerges in 24 hours, become pustules, by 2 wks crusted over; contagious until last scabs fall off
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Rash _____ in __ hours, become p________, by 2 wks crusted over; _________ until last scabs fall off
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Pathogenesis
Step 10 |
Skin left with pitted, scarred area
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uuuuggglyyy
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Treatment
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No treatment available - TLC
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smallpox = Tough Luck Chap
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Prophylaxis
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vaccine provides immunity for ~10 yrs
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thx jenny poo
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Last natural case of smallpox
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(Variola minor) 1977 in Somalia
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peace out in som---- bitches
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Bioterrorism?
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hell yea, but we've got some variola left in US labs bitches
p.s. it's been sequenced |
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