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26 Cards in this Set

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History
Ancient disease
scars on mummy of Ramses V
fall of Aztec and
Inca civilizations
French-Indian War, intentional use of smallpox
History
Variolation
pre-vaccination process may have began in Egypt
Lady Montague had son and daughter variolated
Edward Jenner discovered vaccine
Epidemiology
pre-variolation/vaccination
everyone got it and either died or lived with the scars
Forms:
Variola Major
Variola Minor
Variola Major
Variola Minor
25-50% mortality (most common form - 90% of cases
1 % mortality
Epidemiology
Ever eradicated?
Yes. 1980
Etiology
family
Poxviridae family
Poxviridae family:
Variola virus; an orthopoxvirus - enveloped DNA virus. Hardy virus, survives outside host longer than most viruses
Shaped like large brick
Variola virus; an ____________ - ________ DNA virus. Hardy virus, survives ______ host longer than most viruses
Shaped like large ______ 200 NM diameter
Poxviridae family continued:
variola Major
highly virulent; causes toxemia, shock, and hemmorhagic form
Transmission
Primarily through resp. droplets; fomites possible sources because of durability of virus
transmission
also through
bedding, clothing possible
after infection...is one immune to the disease?
Lifelong immunity usually results from surviving any form of the disease
Pathogenesis
Step 1
Virus attaches to cells in mucous lining of nasopharaynx
virus ______ to cells in ______ lining of ____________
Pathogenesis
Step 2
Invades lymph nodes in area and multiplies there
invades l_____ n_____ in area and __________ there
Pathogenesis
Step 3
Invades blood and multiplies in white blood cells
invades b---- and multiplies in ----- blood cells
Pathogenesis
Step 4
Travels to small blood vessels to dermis of skin, clogging them, resulting in scar tissue and lack of pigment in those areas
Travels to small blood v------ to dermis of skin, clo----- them, resulting in scar t----- and lack of pi----- in those areas
Pathogenesis
Step 5
During prodrome, patient has high fever and fatigue
during prodrome, patient has high _____ and _______
Pathogenesis
Step 6
Lesions develop first in mouth and then other parts of body
Lesions develop first in ______ and then other parts of ______
Pathogenesis
Step 7
lesions open in mouth, virus comes out - patient highly contagious
patient becomes highly contagious because
Pathogenesis
Step 8
As rash develops on body, patient may have back and abdominal pain
As ____ develops on body, patient may have ____ and a------- pain
Pathogenesis
Step 9
Rash emerges in 24 hours, become pustules, by 2 wks crusted over; contagious until last scabs fall off
Rash _____ in __ hours, become p________, by 2 wks crusted over; _________ until last scabs fall off
Pathogenesis
Step 10
Skin left with pitted, scarred area
uuuuggglyyy
Treatment
No treatment available - TLC
smallpox = Tough Luck Chap
Prophylaxis
vaccine provides immunity for ~10 yrs
thx jenny poo
Last natural case of smallpox
(Variola minor) 1977 in Somalia
peace out in som---- bitches
Bioterrorism?
hell yea, but we've got some variola left in US labs bitches
p.s. it's been sequenced