Small Molecules/acronyms

Front 1

TOM

Back 1

Transports mitochondrial precursor proteins (unfolded) across outer mitochondrial membrane, using ATP. Recognize N-terminal signal sequences

Front 2

TIM

Back 2

Transports precursor proteins across inner mitochondrial membrane, requires hydrogen gradient

Front 3

OXA

Back 3

Helps insert inner membrane proteins in the inner membrane of the mitochondria

Front 4

SAM

Back 4

In the mitochondrial outer membrane, helps fold proteins that will be embedded

Front 5

HSP 70/60

Back 5

After mitochondrial precursor proteins are threaded through TOM and TIM, helps them assume their correctly folded position

Front 6

Mfn2

Back 6

Mutation causes CMT2, codes for dynamin, active in fusion of mitochondria. Mitochondria membrane protein. Controls fusion of outer membrane. Dominant inheritance (haplo-insufficiency)

Front 7

OPA1

Back 7

Mutation causes optic atrohpy, codes for dynamin active in fusion of mitochondria. Imported into inner mitochondrial membrane. Dominant inheritance (haplo-insufficiency)