Sle P&t Exam #2

Front 1

Compare pt populations w/SLE and drug-induced SLE?

Back 1

SLE: typically young, black, female
DISLE: typically older, white males with a milder dx than idiopathic SLE

Front 2

Etiology of SLE?

Back 2

possible loss of self-tolerance (autoaB production) w/ possilbe hormonal, genetic (HLA?) & environmental triggers (UV light, chemicals/drugs, infections)

Front 3

Clincial presentation of SLE?

Back 3

constitutional symptoms (universal), muscoloskeletal, skin, pulmonary, cardiac, CNS, GI, kidney, hematologic-MULTI-ORGAN SYSTEM DISEASE!!

Front 4

Describe pathophy of SLE?

Back 4

dvlpmt of excessive autoantibodies & immune complexes; ABs to nuclear, cytoplasmic, & cellular surface components; hyperactive lymphocytes & impairment of immune reg (CD8 supp T-cells release cytokines, Ils, y-interferon, TNF)

Front 5

Autoantibodies seen in SLE?

Back 5

ANA, anti-ds DNA, anti-ss DNA, RNA abs, lupus anticoagulant (paradoxical rxn seen)

Front 6

Describe constitutional symptoms of SLE?

Back 6

fever, fatigue, wt loss

Front 7

Describe muscoloskeletal symptoms of SLE?

Back 7

arthritis, arthralgias, myalgias

Front 8

Describe skin manifestations of SLE?

Back 8

butterfly (malar) rash usually post-sun exp, photosensitivity, raynauds phenomenon (cyropercipitate digits turn blue)

Front 9

describe pulmonary manifestations of SLE?

Back 9

chest pain/pleurisy, lupus pneumonitis (fever, dyspnea, tachypnea, cough, pleuritis)

Front 10

describe cardiac manifestations of SLE?

Back 10

pericarditis, myocarditis, murmurs/EKG changes

Front 11

describe CNS presentation of SLE?

Back 11

psychosis, seizures due to inflammation of CNS

Front 12

DESCRIBE GI SYMPTOMS OF SLE?

Back 12

N,ab pain, hepatomegaly, splenomegaly, mucosal ulcers

Front 13

Describe lupus nephritis & glomerulonephritis?

Back 13

renal involvement=poorer outcome;
ESRD major cause morbi/mortal in SlE

Front 14

symptoms of lupus nephritis?

Back 14

proteinuria (3+), casts, hematuria/pyuria in the absence of infections, incr scr, abnl renal biopsy

Front 15

describe hematological presentation of SLE?

Back 15

anemia of chronic dx, hemolytic anemia, leukopenia/thrombocytopenia, lupus anticoagulant (antibody against lipid moiety of the prothrombin activator complex causing hyoercoagulability & thrombosis)