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12 Cards in this Set
- Front
- Back
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Common features/signs and symptoms of SLE? (7)
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Arthropathy (90%)
Raynauds Butterfly (photosensitivity) rash Fatigue Nausea + gen malaise Alopecia Mucosal ulceration |
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Less common features (11)
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Myocarditis + pericarditis
Myositis Pleural effusions Pneumonitis Pleurisy Glomerulonephritis Psychosis Depression Seizures Headaches Leucopenia, anaemia + thrombocytopenia |
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Prevalence (3)
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Females
15-40yrs Afro-carribbean, Asian |
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Causes of flares (4)
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Stress
UV light Infection Oestrogen containing OCP |
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Autoantibody tests (3)
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ANA (95% sensitive - non specific)
Anti Ro + Anti La (also in sjogrens + pulm fibrosis) Antibodies to dsDNA (v. specific) |
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Other clinical tests (6)
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FBC
ESR (CRP often normal) Urine dipstick Compliment levels (usually lowered) Renal biopsy Skin biopsy |
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Links other conditions (3)
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Sjogrens syndrome
Antiphospholipid antibody syn Raynauds |
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Treat mild SLE (2)
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NSAIDS
Hydroxychloroquine |
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Treat moderate SLE (2)
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Corticosteroids
Azathioprine + Methotrexate (steroid sparing) |
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Treat severe SLE (3)
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Corticosteroids +
Cyclophosphamide Mycophenoplate |
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Iatrogenic causes of SLE? (5)
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Hydralazine
procainaminde isoniazid minocycline chlorpromazine |
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Memory aid for features SLE =
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A RASH POINts an MD to diagnosis
Arthritis Renal impairment ANA antibodies Serositis (pleura + pericardium) Haemotological - pancystopenia (haemolytic anaemia, leukopenia, lymphopenia, thrombocytopenia) Photosensitivity Oral ulcers Immune disorder (antiphospholipid, anti dsDNA, anti SM) Neurological disorder - Seizures, psychosis Malar rash Discoid rash |
