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45 Cards in this Set
- Front
- Back
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What are the diseases caused by B19 Parvovirus?
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erythema infectiosum; gloves and socks syndrome
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What are the other names for erythema infectiosum?
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fifth's disease, slapped cheek disease
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What does erythema infectiosum cause?
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hydrops fetalis; transient aplastic crisis, arthralgia, hemophagocytic syndrome
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How is erythema infectiosum spread?
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respiratory droplets and blood
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Are most erythema infectiosum patients symptomatic or asymptomatic?
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asymptomatic
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What is the pathogenesis for erythema infectiosum?
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acquired via respiratory tract, brought to local lymph nodes, migrating wbc's take virus to bone marrow, infection occurs
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What antigen is expressed that B19 parvovirus needs to replicate? Which cells have this?
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P antigen; proerythroblast and reticulocyte
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What are the symptoms of erythema infectiosum?
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fever, pruritic lacy rash, arthralgia
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What is unique about the sequence of gloves and socks syndrome?
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rash occurs prior to immune response
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Does gloves and socks syndrome occur more in children or adults?
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adults
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What is the pathogenesis of gloves and socks syndrome?
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endothelial cell infection
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When is the greatest risk of adverse outcome in non-immune hydrops fetalis?
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11-23 weeks gestation
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What is the fatality rate of non-immune hydrops fetalis?
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50%
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What are the major effects of non-immune hydrops fetalis?
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severe anemia and cardiac failure
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How can non-immune hydrops fetalis be treated?
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fetal transfusion and postnatal IVIG
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How is TAC treated?
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transfusion
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How can B19 parvovirus be detected?
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IgM elisa; PCR, BM pathology (shows giant cells with inclusions)
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What % of malignant cervical carcinoma is caused by HPV?
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95%
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What is the most common STD?
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HPV
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Papillomas and polyomas belong to what group of viruses?
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papovavirus
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What are the 3 polyomas?
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BK, JC, SV40
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What is different about the BK virus?
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it is the only known benign viral infection
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What is the only exception to BK's benign features?
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can occur in kidneys in immunocompromised
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What is JC virus responsible for?
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encephalitis in immunodeficient patients
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What is SV40 responsible for?
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contaminant in polio vaccines
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What virus has ds DNA, host histones, overlapping genes, and disrupts p53/Rb?
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HPV
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Where are flat warts usually seen?
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face and trunk
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Which wart can be pigmented and occur near mucocutaneous area; has high carcinogenic potential?
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bowenoid warts
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What happens in EV?
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whole body becomes one giant wart
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Which warts have the highest potential for malignancy?
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penile, vulvar, vaginal, oral, and laryngeal
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Which HPV strains are included in the new HPV vaccine?
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6, 11, 16, and 18
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HPV 6 and 11 cause what? What is the malignancy potential?
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genital warts; low
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HPV 16 and 18 cause what? What is the malignancy potential?
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cervical cancer; highest
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Which genes in HPV are the most importnat in tumor genesis?
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E6 and E7
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What does E7 do?
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blocks Rb-causes unstoppable proliferation
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What does E6 do?
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inhibits p53-unstoppable proliferation; stimulates telomerase-adds telomere length
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Where are HPV receptors located?
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deep basal cell layer
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What happens after HPV gets to deep basal cell layer?
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it uncoats and waits for the skin layer to differentiate, then it begins replication
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In what layer does HPV replication BEGIN?
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in the prickle layer of differentiation (acanthosis)
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In what layer does HPV replication begin IN FULL?
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granular layer
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At what point in HPV infection will it become infectious?
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after tissue vacuolization and destruction occurs, the virus will reach the top layer of skin
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What structures are diagnostic for any HPV?
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koilocytes-vacuoles that develop that destroy tissue in HPV
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How can detection of very small flat warts be enhanced?
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dilute acetic acid
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What is they hybrid capture test used for?
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genital warts (via pap smear in females)
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What kinds of immunotherapy are used to treat warts?
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interferon, imiquimod
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