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47 Cards in this Set
- Front
- Back
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Describe the herpesvirus:
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large DNA virus with about 200 genes; shows multinucleated giant cells
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What kind of cytopathology test shows herpesvirus?
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tzank smear
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In addition to genital symptoms, what other symptoms can HSV-2 cause?
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meningitis, gingivostomatitis, pharyngitis, herpes whitlow, and perianal herpes
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HSV-1 is usually passed along during symptomatic or asymptomatic stage?
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asymptomatic
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Gingivostomatitis can resemble what other disease? What is this other disease caused by?
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herpangina; coxsackie virus
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How can you differentiate herpangina and gingivostomatitis?
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herpangina not usually external; gingivostomatitis not in back of throat
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Herpes labialis is caused by herpes virus, which is latent where?
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trigeminal ganglion
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What are diseases caused by HSV-1?
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gingivostomatitis, herpes labialis, keratoconjunctivitis, eczema herpeticum, meningoencephalitis, herpes gladiatorum, herpetic whitlow
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Which HSV-1 disease is a life-threatening condition?
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eczema herpeticum
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What is the leading cause of infectious blindness in the US?
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keratoconjunctivitis
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Is eczema herpeticum a primary or secondary infection?
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primary
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What are the most serious complications of chickenpox?
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pneumonia and encephalitis
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When does the chickenpox rash normally appear?
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2 weeks post-infection
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What disease is indicated with "umbilicated eruptions"?
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chickenpox
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Normally, zoster rashes follow along what?
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dermatomes
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What is the most serious complication from zoster?
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post-herpetic neuralgia
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What are the 4 stages of zoster?
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vesicles, pustules, crusts, and ulceration
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What is the disease when there is no rash, but there is neuralgia in zoster?
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zoster sine herpete
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Are HSV-1/2 and VZV examples of neurotropic or lymphotropic disease?
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neurotropic
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EBV causes what disease? CMV?
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mono; primary cause of fetal and neonatal disability
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What virus causes roseola?
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HHV-6
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Roseola also known as:
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Sixth disease, exanthem subitum
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What are the clinical symptoms of roseola?
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high fever and rose-colored rash; hemophagocytic syndrome
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What age group is roseola commonly seen in?
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6 months to 3 years old
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In addition to causing a roseola type viral infection, what else does HHV-7 cause?
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chronic fatigue
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What disease does HHV-8 cause?
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Kaposi's sarcoma herpesvirus
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Kaposi's sarcoma can be seen in what population in addition to immunosuppresed?
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mediterranean men
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Treatment for all neurotropic and lymphtropic viral infections involves what?
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inhibit viral DNA polymerase
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What virus is made of ds DNA, is brick-shaped, surrounded by membrane, and is largest of all in its class?
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smallpox
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2 most significant poxviruses?
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smallpox and molluscum contagiosum
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What virus causes smallpox?
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variola
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What is the vaccine for smallpox?
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vaccinia
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How long post-exposure will smallpox papules show up?
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17 days
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Is there a treatment for smallpox?
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no
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Molluscum contagiosum primarily affects what population?
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children
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What is orf? Who is affected?
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poxvirus; farmer
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What are milker's nodules caused by?
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paravaccinia virus
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HSV-1 and 2 and VZV reactivate to cause what?
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recurrent disease
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How does the latent virus replicate?
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virus is tethered to DNA, when chromosome is duplicated, so is virus
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What do the lesions look like in erythema multiforme?
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bulls-eye, target lesions
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EM usually follows what?
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allergic reaction to drugs
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What virus is reactivated in EM?
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HSV-1
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What is the pathogenesis for EM?
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macrophages ingest HSV-1 virus particles, then these end up in vessels, causing immune response to particles, results in target lesions
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What is the vaccine for VZV?
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varivax
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What vaccine is available for immunocompromised and neonates to prevent VZV?
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VariZIG
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What is smallpox vaccine IG used for?
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treating vaccine patients
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How is smallpox vaccine administered?
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bifurcated needle with innoculum is scratched on skin and a vesicle develops
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