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32 Cards in this Set
- Front
- Back
Normal Skin histology
Learn the layers of the Epidermis |
DO IT ON YOUR OWN!
(note. Lucidum only present in sole and palms) |
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Dermatitis
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inflammation of the skin
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Atopic (Eczematous) Dermatitis
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Pruritic (itching), erythematous,
oozing rash with vesicles (fluid filled <1 cm) and edema Associated with asthma and allergic rhinitis |
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Atopic Dermatitis
What part of the body does it usually involve? What type of hypersensitivity reaction is it? |
Type I hypersensitivity reaction
Often involves the face and flexor surfaces |
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4 year old pt. presents with chronic allergic rhinitis and a rash which itches on his face. What does this kiddo probably have?
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Atopic Dermatitis
Associated with allergic rhinitis and asthma (itchy, red, oozing with vesicles/edema) |
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Contact Dermatitis
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Pruritic (ithcy), erythematous, oozing rash with vesicles and edema
Arises upon exposure to allergens (eg. Poison ivy, nickel jewelry, irritant chemicals, drugs) |
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17 yr old gent pt. comes in complaining of itching and redness on his arm which started 1 week after getting a rolex for his birthday. What kind of skin pathology does he have?
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Contact Dermatitis
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What is the difference b/w contact dermatitis and Atopic dermatitis?
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Both look same PHYSICALLY (red, itchy, oozing, vesicles/edema)
Atopic associated with asthma and allergic rhinitis Contact associated with some irritant |
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What is the treatment for Dermatitis?
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Topical Steroids!
(Contact dermatitis: get rid of offending agent) (atopic: treat/manage asthma and allergic rhinitis) |
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Acne Vulgaris
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Comedones (white or blackheads), pustules (pimples), and nodules
Common in adolescents (duh) Happens due to chronic inflammation of hair follicles |
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MOA behind Acne Vulgaris: Comedones
(note: what is it's relationship with adolescents and hormonal changes) |
Sebaceous glands produce sebum (oily/waxy liquid). They have androgen receptors thus during teen age years they are highly active.
The sebum is secreted into the hair follicles (located in dermis of skin). Keratin production is also increased. This clogs the hair follicle causing black/white head |
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MOA behind Acne vulgaris: pimples (pustules)
(note: start from the hair follicle being clogged aka black/white heads) |
Since the hair follicle is clogged by keratin and sebum, flow is messed up.
Whenever you have stasis, infection/inflammation may occur. Propionibacterium acnes infects |
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When and how does the propionibacterium acnes cause infection?
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It breaks down the excess sebum with lipases producing PRO-inflammatory fatty acids.
it infects when hair follicle is clogged (sebum + keratin) |
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Why use benzoyl peroxide in acne?
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Antimicrobial
Kills P.acnes (bacteria) |
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Why is vitamin A derivatives for acne vulgaris treatment?
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They decrease the production of keratin (decrease the clog!)
Vitamin A is good at maintaining specialized epithelium (eg. hiar follicle) |
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16 yr old female pt. presents with some red spots on her face. She has been having them for 2 years now and she is confused as to what it is. What do you tell her the reason for this skin issue?
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TEENAGER!
This is acne vulgaris caused by hormones and clogged hair follicles in the dermins |
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Psoriasis
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Well-circumscribed, salmon colored plaques with silvery scale;
can have nail pitting Due to excessive keratinocyte proliferation |
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What common places does psoriasis show up (location on body)
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Extensor surfaces (knees and elbows) and scalp
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What HLA is psoriosis associated with?
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HLA-C
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What is nail pitting?
What skin disorder is nail pitting associated with |
Nail pitting is depression of the nails
Psoriasis |
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What skin pathology does this slide show?
Name some features |
Excessive keratin
Acanthosis (epidermal hyperplasia) Parakeratosis (retention of nucleus past the stratum granulsom layer) Collection of neutrophils in stratum corneum Thinning of the epidermin above the ELONGATED dermal papillae**** |
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What is Acanthosis?
What is parakeratosis? |
Epidermal hyperplasia = Acanthosis
parakeratosis = retaining nuclues past the stratum granulosm layer (should go away as you move up) |
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What is the reason for the silvery scaling in psoriasis?
What is Auspitz sign**? |
silvery scaling is due to excess keratin
Auspitz sign: Bleed when you scrape away the silvery scaling b/c the bv are located in the papillae (DERMIS) which are really close to the surface of skin |
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What is the treatment for psoriasos?
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Steroids
PUVA (psoralen UVA): put psoralen on skin so you can absorb the UVA better. This will destroy the keranocytes |
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What does this pt. have?
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psoriasis
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Lichene Planus
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Disorder of unknown etiology which effects skin and mouth
Involves the 5 Ps. |
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What are the 5 P's in Lichen planus?
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Pruritic
Planar Polygonal Purple papules Often with reticular white lines on their surface |
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What is Wickham striae?
If it is in Lichen planus, what body/organ is involved? |
Reticular white lines on the surface of Lichen planus and other diseases
oral involvement manifests as Wickham striae |
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What is this?
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Wickhmam striae
maybe Lichen Planus pt. |
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What are the common places for Lichen Planus to be?
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Wrists, elbows and oral mucosa
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What is this? How can you tell?
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This pt. has Lichen Planus
-Saw-tooth appearance at the Epidermis/dermis junction -inflammation at the epidermis/dermis junction (blue dots) |
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What group of ppl is Lichen Planus commonly associated with?
(note: viral infection) |
Chronic Hepatitis viral infection
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