Skin Cancer Spring 2010 Donna Class

Front 1

Basal cell
epidemiology

Back 1

65+years

Front 2

basal cell
pathogenesis

Back 2

nondifferentiated epithelial cells of the basal layer of skin and skin appendages

Front 3

basal cell
clinical manisfestations

Back 3

smooth, red, milky, and pearly borders

Front 4

basal cell RT:
energy

Back 4

Electron of 3-4Mev to more than 20Mev.

80% isodose line – determined by 1/3 of energy.

Front 5

basal cell RT
filtration

Back 5

Range of electrons equal ½. Increase E, increase filtration.

Front 6

basal cell dose

Back 6

Doses of 30-50Gy with 2—5Gy per fraction

Front 7

basal cell results of TX modalities

Back 7

May be surgically excised.

RT is beneficial for the treatment of multiple lesions or legions that involve regional lymph nodes. Postoperative irradiation for pts with incomplete resection.

Chemo used to treat advanced, metastatic basal cell (usually in combination with RT or surgery)

Front 8

Melanoma
epidemiology

Back 8

All ages and increasing in younger

Front 9

melanoma
pathogenesis

Back 9

SSM – Superficial Spreading Melanomas

NM – Nodular melanomas

LMM – Lentigo Maligna Melanoma

ALM – Acral Lentiginous Melanomas

Front 10

melanoma
SSM color

Back 10

brown black red pink or white

Front 11

melanoma
NM color

Back 11

dark brown, blue, or black-blue

Front 12

melanoma
LLM color

Back 12

brown black or white

Front 13

Melanoma
ALM color

Back 13

tan or brown

Front 14

clarks levels

1

Back 14

Level 1 – confinement to the epidermis above the basement membrane.

Front 15

clarks's levels

2

Back 15

Level 2 – invasion through the basement membrane to the papillary dermis.

Front 16

clarks's levels

3

Back 16

Level 3 – presence of tumor cells at the papillary-reticular junction of the dermis.

Front 17

clarks's levels

4

Back 17

Level 4 – invasion into the reticular dermis.

Front 18

clark's levels

5

Back 18

Level5- invastion into subcutaneous fat

Front 19

role of surgery in melanoma

Back 19

Surgery is the main treatment option for primary melanomas and typically consists of en bloc removal of the intact tumor or biopsy site with a margin of normal-appearing skin and underlying subcutaneous tissue.

Front 20

role of RT: melanoma
role
dose

Back 20

Limited primarily to the palliative treatment of metastatic disease sites. Fractionation doses of 2Gy or above are used to treat melanomas.

Front 21

role of chemo in melanoma

Back 21

Chemotherapy is used as a treatment for melanomas that have metastasized.

Front 22

ABCD:

A

Back 22

A-Asymmetry: melanomas tend to be asymmetrical; most benign moles tend to be symmetrical.

Front 23

ABCD

B

Back 23

B-Border: melanomas tend to have notched, uneven borders; most benign moles tend to possess clearly defined, smooth borders.

Front 24

ABCD

C

Back 24

C-Color: melanomas can contain different shades of black, brown, or tan; benign moles tend to be uniformly tan or brown.

Front 25

ABCD

D

Back 25

D-Diameter: most melanomas have a diameter greater than 6 mm; most benign moles tend to be less than 6 mm in diameter.

Front 26

Skin reactin in order of occurance:

Back 26

o Erythema
o Pigmentation
o Dry desquamation
o Moist desquamation
o Temporary hair loss
o Change in oil and sweat glands

Front 27

treatment advised or utilized for skin reactions

Back 27

o Cotton clothing
o Certain lotions and deodorant
o Loose fitting clothes

Front 28

repair mechanisms

Back 28

it occurs from the edges of the filed and from the epithelial cells of the hair follicles

Front 29

4 late skin reactions

Back 29

o Fibrosis
o Telangiectasia
o Hyperpigmentation / Hypopigmentation
o Necrosis