Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
|
non-depolarizing blockers
|
hit nicotinic receptors
Pancuronium Vecuronium Atracurium Cisatracurium Mivacurium Rocuronium |
|
|
depolarizing blockers
|
succinyl choline (suxamutiumum)
|
|
|
spasmolytics - acting @ cns synapse in spinal cord/cortex
|
Diazepam/lorazepam
Baclofen Tizanidine Gabapentin |
|
|
others
|
Dantrolene
Botulinum toxin |
|
|
uses - motor endplate acting
|
used in surgery to reduced inhaled anesthicis
- prevent movement in response to cuttin - maintain controlled ventilaton - faclicate intubation NO EFFECT ON CONSICIOUSNESS or ANALGESIC feel the pain, can't communicate |
|
|
other non-surg uses
|
reduce tetanus
diagnosis MG during ECT diagnosis pain caused by nerve root compression |
|
|
drugs actign on Motor end plate
|
Mivacurium
succinyl choline |
|
|
Ca+ storage
|
Dantrolene
|
|
|
non-depol
|
block nicitonic receptor completely
Given IV -first small msucles/rapidly moving...last diaphram...after discontinuing...diaphram is FIRST to recover. |
|
|
depol drugs
|
cause depol - then become instenstive to AcH
give IV, fasciulations may occur.. if LT use...K+ loss may occur from cell! |
|
|
Long duration drugs
|
Turbocuraine
Pancuronium |
|
|
Intermeidate duration
|
Vecuronium
atraciruim - metabolite - laudanosine ~ seizures! |
|
|
Short duration
|
mivacurium
succinyl choline rocurnoium |
|
|
effects on CVS
|
vecuronium ~ best one no effects
pancuronium/succinyl choline ~ increase BP/HR |
|
|
succ choline - pharmokinetes
|
stucture is 2 Ach's
~ metabolizes slower (not by AChase) shortest onset/duration HYPERKALEMIA ! problem may cause hyperthermia alone some ppl may have abn pseduocholinesterase (can't break it down...resp failure) |
|
|
drug interactions
|
Potentiate
Genearl anesthetics aminoglycosiides tetracyclines Ca+2 blockers Antag phentyoin + carbmazepine steriods thephilline |
|
|
Spasmolytics
|
GABA/Glycine
. Diazepam/lorazepam Baclofen heteroadrenoreceptors ~ presynp N terms regulate release - tizanidne |
|
|
Diazepam/lorazepam
|
muscle rlx, w/ or w/o twitching
- stress-induced muscle tension, chronic back pain amp GABA A receptors affinity locacted on post synp alpha motor neurons cl- ion hyperpolerizing. adverse: ~ memory loss ~ hand eye coordination ~ vison SYNGERISTIC EFFECT W/ ALCOHOL |
|
|
Baclofen
|
use in MS/ALS/Trigeminal Neuralsgia
spinal lesions GABA B agnoist presyn endings in spinal chord, via Gi (prevent Ca+ coming in) ~ dont give with diabetics CNS, CVS depression |
|
|
tizandine
|
~ clonidine
a2 agonist pre/post synaptic a2 adrenoreceptors MS/ALS |
|
|
gabapentin
|
generalized tonic-clonic seizures
GABA alalouge, decreases excitiory transmission on ca+2 presynp |
|
|
dantrolene
|
used for
CP malignant hyperthermia Neuroleptic malignant Syndrome serotonine syndrome blocks moblization of Ca+2 from sarcoplasmic recitulum stores MUSCLE weakness...~ adverse |
