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27 Cards in this Set

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achondroplasia
congenital
less chondrocytes ossified
short, short arms/legs, big head
FGFR3 Gene mutation
osteogenesis imperfecta
congenital
abnormal synthesis of collagen type I
4 types
OI type I
AD, mult fx at birth
OI type II
AR, Lethal perinatal, stillborn
OI type III
live to adulthood
kyphoscoliosis
OI type IV
adolescence, fx heals with imperfect bone and develop osteoporosis from disuse
osteopetrosis
dense, mishapen bone
congenital
AR form lethal
disorganized thick trabeculae
core of calcified cartilage
loss of vascular supply
osteoporosis
acquired
low bone mass
bone fragility
high fracture
Primary osteoporosis
affects 15million, common
type I: postmenopausal
type II: age-related
Secondary osteoporosis
identifiable cause like diet
Rickets/OSteomalacia
acquired
bone/epiphyseal cartilage doesn't mineralize
doesn't form normal CaP
Hyperparathyroidism
PRIMARY: high PTH so
more resoprtion of bone
resorption if Ca in renal tub
more Vit D activation
less P reabsorption in renals
BROWN TUMOR: hyperosteoclast activity
stones, bones, moans, groans
SECONDARY: renal osteodystrophy more Ca excreted with protein
Osteomyelitis
infection
via bacteria (staph aureus)or TB
inflammation of bone/marrow
Cloaca=draining sinus
sequestrum:devasc necrotic bone
involcrum: abcess formation by periosteum
Paget's disease
OSteitis deformans
thinkening/weakening of bone
Triphasic:
1. OC, hypervasc, bone loss
2. OC+OB
3. Dense mineral bone
can develop sarcoma
Avascular necrosis
w/or w/out trauma
1. influx neutrophils/inflammation
2. fibrovascular tissue
3. mesenchyme-->OB
4. new bone deposition
5. necrotic bone removal

Creeping substitution: replace old with new bone
Rickets/OSteomalacia
acquired
bone/epiphyseal cartilage doesn't mineralize
doesn't form normal CaP
Hyperparathyroidism
PRIMARY: high PTH so
more resoprtion of bone
resorption if Ca in renal tub
more Vit D activation
less P reabsorption in renals
BROWN TUMOR: hyperosteoclast activity
stones, bones, moans, groans
SECONDARY: renal osteodystrophy more Ca excreted with protein
Osteomyelitis
infection
via bacteria (staph aureus)or TB
inflammation of bone/marrow
Cloaca=draining sinus
sequestrum:devasc necrotic bone
involcrum: abcess formation by periosteum
Paget's disease
OSteitis deformans
thinkening/weakening of bone
Triphasic:
1. OC, hypervasc, bone loss
2. OC+OB
3. Dense mineral bone
can develop sarcoma
Avascular necrosis
w/or w/out trauma
AVN w/trauma
single event, adult, femoral head
AVN w/out trauma
ischemia
femoral head/hip
Osteoma
benign neoplasm
solitary lesion
thick heavy traberculae
osteoid osteoma
osteoblastoma
benign neoplasm
vertebral column
backache
hyperplastic OB& extensive vasc
osteochondroma
exostoses
benign neoplasm
cartilage cap
solitary or AD
chondroma
mature hyaline cartilage
Olliers:symmetric...ENDOCHONDROMA
Maffucci's: random w/hemangioma
Giant Cell TUmor
20% of all benign tumors
locally aggressive
can metastisize if manipulated
many OC-- multinucleate