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27 Cards in this Set
- Front
- Back
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achondroplasia
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congenital
less chondrocytes ossified short, short arms/legs, big head FGFR3 Gene mutation |
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osteogenesis imperfecta
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congenital
abnormal synthesis of collagen type I 4 types |
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OI type I
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AD, mult fx at birth
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OI type II
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AR, Lethal perinatal, stillborn
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OI type III
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live to adulthood
kyphoscoliosis |
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OI type IV
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adolescence, fx heals with imperfect bone and develop osteoporosis from disuse
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osteopetrosis
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dense, mishapen bone
congenital AR form lethal disorganized thick trabeculae core of calcified cartilage loss of vascular supply |
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osteoporosis
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acquired
low bone mass bone fragility high fracture |
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Primary osteoporosis
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affects 15million, common
type I: postmenopausal type II: age-related |
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Secondary osteoporosis
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identifiable cause like diet
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Rickets/OSteomalacia
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acquired
bone/epiphyseal cartilage doesn't mineralize doesn't form normal CaP |
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Hyperparathyroidism
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PRIMARY: high PTH so
more resoprtion of bone resorption if Ca in renal tub more Vit D activation less P reabsorption in renals BROWN TUMOR: hyperosteoclast activity stones, bones, moans, groans SECONDARY: renal osteodystrophy more Ca excreted with protein |
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Osteomyelitis
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infection
via bacteria (staph aureus)or TB inflammation of bone/marrow Cloaca=draining sinus sequestrum:devasc necrotic bone involcrum: abcess formation by periosteum |
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Paget's disease
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OSteitis deformans
thinkening/weakening of bone Triphasic: 1. OC, hypervasc, bone loss 2. OC+OB 3. Dense mineral bone can develop sarcoma |
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Avascular necrosis
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w/or w/out trauma
1. influx neutrophils/inflammation 2. fibrovascular tissue 3. mesenchyme-->OB 4. new bone deposition 5. necrotic bone removal Creeping substitution: replace old with new bone |
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Rickets/OSteomalacia
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acquired
bone/epiphyseal cartilage doesn't mineralize doesn't form normal CaP |
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Hyperparathyroidism
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PRIMARY: high PTH so
more resoprtion of bone resorption if Ca in renal tub more Vit D activation less P reabsorption in renals BROWN TUMOR: hyperosteoclast activity stones, bones, moans, groans SECONDARY: renal osteodystrophy more Ca excreted with protein |
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Osteomyelitis
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infection
via bacteria (staph aureus)or TB inflammation of bone/marrow Cloaca=draining sinus sequestrum:devasc necrotic bone involcrum: abcess formation by periosteum |
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Paget's disease
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OSteitis deformans
thinkening/weakening of bone Triphasic: 1. OC, hypervasc, bone loss 2. OC+OB 3. Dense mineral bone can develop sarcoma |
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Avascular necrosis
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w/or w/out trauma
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AVN w/trauma
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single event, adult, femoral head
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AVN w/out trauma
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ischemia
femoral head/hip |
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Osteoma
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benign neoplasm
solitary lesion thick heavy traberculae osteoid osteoma |
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osteoblastoma
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benign neoplasm
vertebral column backache hyperplastic OB& extensive vasc |
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osteochondroma
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exostoses
benign neoplasm cartilage cap solitary or AD |
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chondroma
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mature hyaline cartilage
Olliers:symmetric...ENDOCHONDROMA Maffucci's: random w/hemangioma |
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Giant Cell TUmor
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20% of all benign tumors
locally aggressive can metastisize if manipulated many OC-- multinucleate |
