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5 Cards in this Set
- Front
- Back
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What is and ITAM?
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immunoreceptor tyrosine base activation motif in cyctoplasmic domain of BCR and TCR signaling subunits
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4 steps of BCR signal initiation?
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1. ITAM phosporylation
2. recruitment of Src kinases and Syk 3. phosphorylation of adaptor proteins and scaffold proteins 4. Recruit SH2 domain signaling proteins |
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5 steps of TCR signal initiation?
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1. TCR engagement allows Fyn (Src kinase) to phosphorylate ITAMs
2. CD4/CD8 binding brings Lck, phosphorylates more ITAMs 3. ZAP-70 binds dually-phospd ITAMS 4. Lck phosphts ZAP-70 and increases it's kinase activity 5. ZAP-70 phosporylates adaptor proteins |
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How many ITAMs does BCR IgA and IgB have?
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2 total (one on each Ig)
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How many ITAMs does TCR CD3 have and Zeta chains have?
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3 on each Zeta chain. 1 on each CD3. Total of 10.
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