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42 Cards in this Set

  • Front
  • Back
oxidation
phase I
reduction
phase I
hydroxylation
phase I
dealkylation
phase I
deamination
phase I
desulfuration
phase I
dechlorination
phase I
hydrolysis
phase I
glucoronidation
phase II
sulfation
phase II
acetylation
phase II
glutathione conjugation
phase II
methylation
phase II
glycine conjugation
phase II
major site of drug metabolism
liver
CYP3A4 location
intestinal epithelium
alcohol dehydrogenase location
stomach
other names for CYP
mixed function oxidases (MFO)
monoxygenases
CYP450 requires...
reducing agent- NADPH
flavoprotein- NADPH CYP450 reductase
CYP
2
d
6
super family
gene family (1-12)
subfamily (a-z)
gene
parent drug binds to oxidized/reduced form of CYP450
oxidized (FE3+)
what happens to morphine when metabolized?
morphine-6-glucoronide = 100x more potent than morphine

and

morphine-3-glucoronide = inactive
what happens when minoxidil is metabolized?
minoxidil sulfate = active
phenytoin
CYP inducer
carbamazepine
cyp inducer
barbituates
cyp inducer
rifampin
cyp inducer
ethanol
cyp inducer
griseofulvin
cyp inducer
st. john's wort
cyp inducer
aromatic hydrocarbons
cyp inducer
macrolide antibiotics
cyp inhibitor
triazole antifungals
cyp inhibitor
ritonavir (HIV protease inhibitor)
cyp inhibitor
fluoxetine
cyp inhibitor
nefazodone
cyp inhibitor
cimetidine
cyp inhibitor
-dipine's
grapefruit juice
-statins
grapefruit juice
cyclosporine
grapefruit juice
carbamazepine and clomipramine
grapefruit juice
p-glycoprotein
MDR protein- export drug out of cells