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90 Cards in this Set

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Melphalan
Nitrogen mustard~ alkylating agent
Chlorambucil
Nitrogen mustard~ alkylating agent
Cyclophosphamide
Nitrogen mustard~ alkylating agent
Infosfamide
Nitrogen mustard~ alkylating agent

Testicular cancer
Thiotepa
Ethylenimine ~ alkylating agent
Busulfan
Alkylsulfonate ~ alkylating agent
BCNU (carmustine)
Nitrosourea ~ alkylating agent

Malignant glioma
CCNU (lomustine)
Nitrosourea ~ alkylating agent
Methyl CCNU (semustine)
Nitrosourea ~ alkylating agent
Streptozocin
Methylnitrosourea ~ alkylating agent

Pancreatic cancer
Dacarbazine
Triazene ~ alkylating agent
Temozolamide
Triazene ~ alkylating agent

Anaplastic astrocytoma
Cisplatin
~ alkylating agent
Testicular cancer
Procarbazine
~ alkylating agent (DNA, RNA, and protein)

Hodgkin's lymphoma
Vincristine
Natural product
Vinblastine
Natural product
Vinorelbine
Synthetic derivative of vinblastine
Paclitaxel (Taxol)
Taxane ~natural product

Breast and ovarian cancer
Prevention of restenosis
Abraxane
Protein bound nonparticle formulation of Taxol
Dacetaxel (Taxotere)
Synthetic analogue of Taxol
VP-16 (etoposide)
Epipdophyllotoxin~ natural product

Hodgkin's dz, Diffuse histiocytic lymphoma, and small cell of the lung
VP-26 (teniposide)
Epipdophyllotoxin~ natural product

Hodgkin's dz, Diffuse histiocytic lymphoma, and small cell of the lung
Irinotecan
Camptothecin derivative~ natural product

Lung and metstatic colon cancer
Topotecan
Camptothecin derivative~ natural product
Dactinomycin
Antibiotic
Can cause radiation sensitivity
Daunorubicin
Anthracycline~ antibiotic

Cardiotoxicity
Doxorubicin
Anthracycline~ antibiotic

Cardiotoxicity
Epirubicin
Anthracycline~ antibiotic

Cardiotoxicity
Mitoxantrone
Anthracycline~ antibiotic

Cardiotoxicity
Dexrazoxane
Fe chelator
Given to reduce cardiotoxicity from Anthracyclines
Bleomycin
Antibiotic

DNA binding and Fe binding regions
Methotrexate
Antimetabolite- folic acid analogue

Affects S phase of DNA cycle
Leucovorin
Abborts MTX toxicity
Pemetrexed
Antimetabolite- Folate antatgonist
5-Fluorouracil
Antimetabolite- Pyrimidine Analogue
Floxuridine
Antimetabolite- Pyrimidine Analogue
Capecitabine
Antimetabolite- Pyrimidine Analogue

Metastatic breast and colon cancer
3-deazauridine
Antimetabolite- Uracil analogue
6-azauridine
Antimetabolite- Uracil analogue
Cytosine arabinoside
Antimetabolite- cytidine analogue

Hematologic malignancies
Gemcitabine
Antimetabolite- cytidine analogue

Advanced breast cancer, non small cell lung cancer, pancreatic carcinoma, ovarian cancer
5-azacytidine
Antimetabolite- pyrimidine analogue (cytidine)

Myelodysplastic syndrome
6-mercaptopurine
Antimetabolite- purine analogue
6-thioguanine
Antimetabolite- purine analogue
Pentostatin
Antimetabolite- purine analogue

Hairy cell leukemia
Clofarabine
Deoxyadenosine analogue

(-) DNA poly
Hydroxyurea
Antimetabolite
Asparaginase
Enzyme
Imatinib mesylate (Gleevec)
Biological response modifier

CML and GI stromal tumors
Erlotinib
BRM

(-) EGF receptor tyrosine kinase
Gefitinib
BRM

(-) EGF receptor tyrosine kinase
Trastuzumab (herceptin)
BRM

Her2 (+) breast cancer
Cetuximab
BRM
Bevacizumab
BRM

VEGF receptor
Rituximab
BRM

Non-Hodgkin's lymphoma
Can reactivate HBV
Ibritumomab tiuxetan (Zevalin)
BRM

Linked to yttrium-90 and indium-111
Tositumomab
BRM

Linked to iodine-131
Gemtuzumab ozogamicin (Mylotarg)
BRM

Acts at Myeloid cell surface antigen CD33
Calicheamicin
DNA cleaving Ab conjugated to Mylotarg
Levamisole
BRM
IL-2 (Aldesleukin)
BRM
Interferon alpha
BRM

Multiple Myeloma
Kaposi's sarcoma
Thalidomide
BRM

Multiple Myeloma
All-trans-retinoic acid
BRM

AML
Aresenic trioxide
BRM

Second line for AML
Bexarotene
BRM

Cutaneous T cell lymphoma
Denileukin difitox
BRM
Samarium SM 153 lexidronam
BRM

Metastatic bone lesions
Alemtuzumab
BRM

CLL
Bortezomib
BRM

Multiple myeloma
Celecoxib
BRM- COX 2 inhibitor

Prevention of cancer in familial adenomatous polyposis
Pamidronate
Bisphosphonate

Hypercalcemia, osteolytic bone lesions in MM, metastatic breast cancer, bone metastases from solid tumors
Etidronate
Bisphosphonate

Hypercalcemia, osteolytic bone lesions in MM, metastatic breast cancer, bone metastases from solid tumors
Zoledronate
Bisphosphonate

Hypercalcemia, osteolytic bone lesions in MM, metastatic breast cancer, bone metastases from solid tumors
bacillus Calmette-Guerin (BCG)
BRM

Bladder cancer
Palifermin
BRM

Treats chemo induced mucositis
Tamoxifen
Antiestrogen

Breast cancer in postmenopausal women
Raloxifene
Selective estrogen receptor modulator (SERM)
Fulvestrant (Faslodex)
True estrogen receptor antagonist
Aminoglutethimide
Aromatase inhibitor

2nd line for metstatic breast cancer
Anastrozole
Nonsteroidal Aromatase inhibitor

Alternate 1st line therapy for breast cancer
Letrozole
Nonsteroidal Aromatase inhibitor
Megestrol
Progesterone agonist

Advanced breast cancer
Anorexia/cachaexia
Prostate cancer
Medroxyprogesterone
Progesterone agonist

Advanced breast cancer
Anorexia/cachaexia
Prostate cancer
Leuprolide
Gonadotropin-releasing hormone agonist

Prostate cancer
Metstatic breast cancer in Premenopausal women
Goserelin
Gonadotropin-releasing hormone agonist

Prostate cancer
Metstatic breast cancer in Premenopausal women
Flutamide
Nonsteroidal antiandrogen

Metastatic prostate cancer
Bicalutamide
Nonsteroidal antiandrogen

Prostate cancer
Dietheylstilbesterol
Old drug for prostate cancer not used anymore
Ketoconazole
Adrenal enzyme synthesis inhibitor

2nd line for prostate cancer