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32 Cards in this Set

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Define: part of the vascular system comprised of small arterioles, capillaries and small venules whose function is to regulate blood flow and nutrient exchange betewen blood and tissue.
Microcirculation
What is the primary function of microcirculation?
Regulate blood flow and nutrient exchange between blood and tissue
What are the three types of capillaries?
Continuous, fenestrated, and discontinuous
Name the type of capillary: characterized by endothelium in close contact and in some capillaries tight junctions bind endothelial cell together.
Continuous capillaries
How is transfer of nutrients across continuous capillaries accomplished?
diffsuion or transport processes (endocytosis) through the cell
The heart, skeletal muscle, skin and brain (blood-brain) have what type of capillaries?
Continuous
Name the type of capillary: characterized by gaps between endothelial cellswhich allo diffusion of substance including some large and charge molecule into the interstitium.
Fenestrated
The kidney and intestines have what type of capillaries?
Fenestrated
Name the type of capillary: characterized by large gaps between endothelial cells that allo free exchange of very large molecules and blood cells between the blood and tissue.
Discontinuous
The liver, spleen and bone marrow have what type of capillaries?
Discontinuous
What are the three major factors influencing diffusion through the capillary membrane?
Diffusion thickness, surface area and diffusivity
Define: an expression of how easily a substance moves through a capillary membrane.
Diffusivity.
True/False: the same rules of diffusion through a membrane are applied to the capillary membrane.
True (through 2 bilipid layers)
What are four factors which alter diffusivity?
size, solubility(hydrophobic good, hydrophilic bad), charge (bad), hormones and pharmaceutical which change membrane permeability
What are the four forces that determine fluid movement through the capillary membrane?
Capillary physical (hydrostatic) pressure, interstitial fluid hydrostatic pressure, plasma colloidal pressure, interstitial fluid colloid osmotic pressure.
Define: physical force tending to push fluid out of a capillary
Capillary physical (hydrostatic) pressure
Define: the physical pressure outside the capillary tending to push fluid back into a capillary
Intersitial fluid hydrostatic pressure
Define: Chemical force that can be expressed as a pressure which tends to push fluid back into the capillary.
Plasma colloid osmotic pressure
Define: Chemical force which tends to push fluid out of the capillary
Interstitial colloid osmotic pressure
What three things work together to push fluid into the interstitial fluid?
mean capillary pressure (17.3 mmHg), interstitial fluid pressure (-3 mmHg), and interstitial fluid colloid osmotic pressure (8 mmHg).
What one pressure works to draw fluid out of the interstitial fluid?
Capillary colloid osmotic pressure (28 mmHg)
What is the net force of fluid pushed out of the capillary into the interstitial fluid?
0.3 mmHg
At what point in the capillary is the outward pressure favoring fluid fluid from capillaries?
Arterial end
At what point in the capillary is the inward pressure favoring fluid resorption from the capillary bed?
Venous end
What are two major structures in lymphatic anatomy?
Lymphatic capillaries, and collecting lymphatics
Define: thin walled dead-end lymphatic vessels.
Lymphatic capillaries
Define: larger bor thin-walled vessels with small amounts of smooth muscle.
Collecting lymphatics
What allows large molevules and cells to enter the lymphatic capillaries?
Gaps or pores in the lymphatic capillaries
What permits the one way flow of lymph through the lymphatic system?
Vales made of endothelium flaps
List the four functions of the lymphatic system (three removes and a minimize)
1. Remove unabsorbed interstitial fluid 2. Remove interstitial protein 3. Remove cellular debris 4. Miminize interstitial pressure to prevent edema
Describe intrinsic pumping of lymph.
When the vessel becomes distended, the smooth muscle of lymph vessels contract and squeeze fluid across a valve which prohibits backflow.
List the four factors contributing to edema.
1. Increased capillary permeability 2. decrease in plasma colloid osmotic pressure 3. Elevated capillary pressure 4. Lymphatic obstruction