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28 Cards in this Set
- Front
- Back
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Main form of cholesterol storage
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Cholesterol esters
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Rate limiting step of cholesterol synthesis
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HMG CoA Reductase conversion of HMG to Mevalonic acid
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Chylomicron composition and apoprotein
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90% TG from diet; metabolized to remnants; B48
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Chylomicron remnant composition and apoproteins
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60% TG; 20% C and CE; B48 and E
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VLDL composition and apoproteins
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60% TG; 20% C and CE; B100 and E
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IDL composition and apoproteins
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20% TG; 40% C and CE; B100 and E
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LDL composition and apoproteins
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50% C and CE; some protein; 8% TG; B100
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HDL composition
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25% C and CE; mostly protein; 5% TG; A, C, and E
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Apoprotein that activates LPL
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ApoCII
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LPL Function
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Extracellular enzyme that delivers C, CE to tissues
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Insulin effect on HMG CoA Reductase
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High insulin = upregulates HMG CoAR
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Insulin effect on LPL
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Low insulin = downregulates LPL
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LDL Receptor targets
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ApoB00, ApoE
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Funtion of hepatic lipase
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Remves TG, PL from HDL
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B48 function
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Made in intestine; structural
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E function
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Made in liver and elsewhere; LDLR, remnant receptor ligand
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B100 function
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Made in liver; structural, LDLR ligand
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AI, AII function
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Made in liver, intestine; structural; LCAT, HL cofactor
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CII function
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Made in liver; LPL cofactor
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Chylomicron function
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From duodenum; transport exogenous TG to tissues
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VLDL function
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Made in liver; transport endogenous TG to tissues
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LDL function
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Made from IDL; transport C, CE to tissues, liver
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HDL function
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Made in liver; reverse C, CE transport to liver
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Formula to estimate LDL
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TC - (HDL+TG/5)
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Caveat on LDL formula usage
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TG < 400; best when TG < 250
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TC largely indicates _____
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LDL
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TG largely indicates ____ and ____
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CM and VLDL
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Etiology of FH
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Mutation in LDL receptor
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