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14 Cards in this Set
- Front
- Back
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Linkages between membranes and proteins
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transmembrane proteins, lipid linked (fatty acylated), thioester linked, phophatidylinositol glycan linked, protein-transmembrane protein linked
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lateral diffusion displacement equation
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2* square root(Dt); D= diffusion coefficient--> 10^-8 for lipids, 10^-10 for tethered proteins
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localization of protein to the endoplasmic reticulum
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signal recognition particle stops translation and binds to SRP receptor on surface of ER (GTP-dep. release)
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result of "stop transfer" sequence in translocation of protein into ER
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peptide is moved out of the translocation channel laterally into the membrane
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what proteins are the translocation channels in ER made of?
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Sec61p- 3-4 copies
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Describe glycosylation process in ER
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GlcNAc2Man9Glc3 carbohydrate chain but in cytosol- flipped into ER- attached to proteins
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What is the role of Rab (GTPase switch) in the transport of vesicles
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Rab regulates tethering and SNARE recruitment in vesicular transport; Rab can bind target membrane, as well
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What is the role of KDEL receptors in cis cisterna of golgi
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bind to ER proteins are transport them back to ER
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Sorting of lysosomal hydrolases
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trans-Golgi binds Man-6-P signal, Arf initiates budding, buds fuse with endosomes or lysosome, receptor recycled
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Describe endocytosis of LDL molecule
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LDL receptors bind LDL, vesicle fuses with early endosome, acidification breaks down LDL, receptor recycled
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Fate of EGF and EGF receptor
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both degraded in the lysosome to terminate signal
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lysosomal gene expression (transcription factor)
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TFEB transcription factor promotes transcription of many lysosomal proteins
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Targeting of proteins to peroxisome
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PTS1 or PTS2 targeting sequences (no Golgi processing)
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role of peroxin
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assist in translocation of proteins into the peroxisome
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