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24 Cards in this Set
- Front
- Back
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GnRH
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Secreted in PULSES from the hypothalamus
Stimulates release of FSH and LH |
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Leuprolide
Goserelin Nafarelin |
GnRH superagonist that desensitizes GnRH receptors on Pit.
-Prevents release of FSH and LH greatly reducing circulating testosterone levels. -Good for prostate CA chemo |
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Ganirelix
Abarelix |
GnRH antagonist.
Does the same thing as leuprolide but without the initial increase in FSH and LH |
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hCG
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Induces ovulation
Mimics the LH surge |
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Menotropins
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FSH and LH recovered from the urine of menopausal women
-Produces follicular stimulation |
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Urofollitropin
Follitropin |
menotropins
-produce follicular stimulation |
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Progesterone
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Maintain pregnancy
Suppress uterine contraction and menstration SE: cross over effect at androgen receptor |
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Medroxyprogesterone
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Slow release injected pro-progesterone
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Norethindrone
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Orally effective progesterone with longer half life
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Drospirenone
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Progestin OC
-Has anti androgenic and anti mineralocorticoid activity |
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Norgesterel
Levonorgesterel |
Plan B
High dose progestin pill May interfere w/ implantation |
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Mifpristone
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Competitive antagonist at progesterone and glucocorticoid receptors
-Abortion pill |
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Estradiol
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Steroidal estrogen that is rapidly cleared.
Not orally effective |
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Estrone
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Steroidal estrogen analog
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Mestranol
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Purified mixture of conjugated estrogen like steroids from pregnant mares
-Orally effective prodrug |
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Conjugated Estrogens
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Work as prodrugs that are orally effective
-Mestranol |
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Diethylstilbesterol (DES)
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-Nonsteroidal estrogen
Used for breast cancer before tamoxifen |
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phytoestrogens
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Non steroidal estrogen like compounds from plants
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Clomiphene
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Anti-estrogen
-Blocks negative feedback of estrogen and increases FSH and LH release -Fertility drug |
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Tamoxifen
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SERM for treatment of estrogen dependent breast cancer
*Blood clotting risk increase |
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Raloxifene
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SERM w/ no proliferative effect on the uterus
*increased incidence of thromboembolic events |
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Anastrozole
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Non-steroidal aromatase inhibitor
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Letrozole
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Non-steroidal aromatase inhibitor
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Exemestane
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Steroidal aromatase inhibitor
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