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72 Cards in this Set
- Front
- Back
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Anti A: 4
A cell: 1 B cell: 3 |
Anti A 1
or unexp cold allo ab. |
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Anti A:mf
Anti B: 4 A cell: 3 |
A3
or transfusion (will have mf in A/C) |
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Anti A: 4
Anti B: 2 B cell: 3 |
Gut obstruction = Acquired B cell
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use group O cells to test
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Antiglobs
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Expected Ab
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if ABO is missing, pt will prod ab to react with missing
except Bombay |
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Unexpected Ab
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Ag is missing, pt wont prod ab to it
D ag |
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Solution to test for Antiglobs
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with AHG
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Check cells
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IgG coated D+ cells
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IAT screen cells
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use Gr O
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test for RBC coated with ab directly in body
use EDTA |
DAT
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with II cells
IS= 1 LISS= 2 AHG= 4 |
strength incr wth 1 cell type
unexp IgG or weak IgM |
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II cells
1+ with IS III cells 1+ with LISS, 2+ AHG |
2 diff Ig classes, react at 2 diff temps
IgG and IgM |
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with III cells
1+ for AHG |
IgG
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1+ AHG for A/C or I cells
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auto ab
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mc cause of hemolutic disease of newborn
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Rh
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DCE
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Fischer race
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Most common for whites
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DCe
dce DcE |
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mc for Blacks
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Dce
dce DCe |
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Rh- Hr
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Weiner
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DCe
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R1
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dce
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r
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DcE
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R2
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Dce
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R0
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DCE
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Rz
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dCE
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ry
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dCe
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r I
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dcE
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r II
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Rh ags are
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transmemb polypeps
transverse RBC mem 12x encoded by RHD and RHCE on chrom 1 |
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RHAG
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on chrom 6
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C and c differ by
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4 aa
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E and e differ
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by 1 aa
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strongest expr of D
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R2R2
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react only at AHG phase
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weak D
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Genetic weak D
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inherited
cant form Anti D |
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C in transposition to D
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steric position of C ag weakens expr of D
no Anti D |
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Partial D
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lacks piece (epitope)
should be transf. with Rh- donor is considered Rh+ for transf. |
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on RHD poloypep and RHCE
looks like antiD+C prod by r/r who have been exposed through transfusion |
G ag
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in 2% of whites
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Cw
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Blacks
many epitiopes |
e
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expr on RBC that have c and e in cis
have Rhce |
compound ag
(f) |
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have C and e in cis
RHCe |
RhI (Ce)
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lack all Rh ags
mild hemolytic anemia ince Hgb F decr Haptoglobin defect in RHAG have RHD and RHCE, but cant express |
Rh null
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for crossmatch
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use plasma to pevent detection of complement dep. ab and nonspecf C prime activation
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if hh
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Bombay, Oh
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have to have ___ to make H in secr
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Se
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sese H Le
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no H, A, or B in secr
Le a only |
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Le Sese H
AB |
Leb A B
(Lea H) in secr |
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Anti A: 2
B cell:3 |
possible A2
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Anti A: 3
A cell: 1 B cell: 3 IAT= pos for I/II |
Abn rxn with A
unexp ab, non RBC immune |
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activates compl
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IgG and M
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IgA
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alternate path
forms aggregates |
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stabilized by Ca
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C1qr2s2
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cleaves C4 and C2
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C1s
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cleaves C3
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cells surface
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C3 + B
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stabilized by Mg
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cleave B
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D
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stabilizes C3bBb
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properdin
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syph screening test
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RPR
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main confirm test
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FTA-ABS
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syph test for infants
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PCR
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use cardiolipin and heat
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VDRL
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use cardiolipin
add choline chloride for incr visibility for IgM and G |
RPR
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decr to neg ttier
RPR/VDRL n/p FTA-ABS 80% pos |
primary chancre
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decr titier
RPR/VDRL pos FTA ABS pos |
primary form ln
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decr titer, stays low
RPR/VDRL pos FTA-ABS pos |
2nd leision
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decr titer
RPR/VDRL p/n FTA-ABS pos |
Latent
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incr igG and H
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group O
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in rbcs
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glycolipids
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in secr
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glycoproteins
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prod fucose
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H
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prod n acetyl galactose
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A
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prod galactose
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B
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