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31 Cards in this Set
- Front
- Back
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What would be considered an organ-specific autoimmune disease?
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Hashimoto's thyroiditis
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SLE can be distinguished from RA on the basis of...
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Presence of anti-ds DNA antibodies
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What does SLE stand for?
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Systematic Lupus Erythematosus
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___ appears to trigger an increase in antibodies directed against DNA and stimulate production of platelet activating factor.
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IL-10
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___ differs from the chronic form of lupus in that symptoms usually disappear once the drug is discontinues and is a milder form of the disease.
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Drug-Induced Lupus
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When SLE is suspected what is the first test done for screening?
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Antinuclear Antibodies (ANA)
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After ANA is used to screen for SLE what test is the most widely used and accepted becuase it detects a wide range of antibodies?
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Fluoescent anitnuclear antibody (FANA)
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What would support a diagnosis of drug-induced lupus?
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Antihistone Antibodies
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A homogenous pattern of staining of the nucleus on IIF may be caused by which of the following antibodies?
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Antihistone Antibody
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What are some characteristics of RA?
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Association with HLA-DR genes, Joint involvement that is symmetric, presence of antibody against IgG
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What best describes the slide agglutination test for RF?
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It is a sensistive screening tool.
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Hashimotos thyroiditis can best be differentiated from Grave's disease on the basis of which of the following?
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Decrease in thyroid hormone levels
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Is Hashimoto hyper or hypo
Is Graves hyper or hypo |
hashi = hypo
graves = hyper |
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What is considered a significant finding in Graves disease?
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Antibody to TSHR
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Destruction of the myelin sheath of axons caused by the presence of antibody is characteristic to which disease?
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MS
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Blood was drawn from a woman with suspected SLE. FANA screen was preformed, adn a speckled pattern resulted. Which actions should be taken next?
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Perform an antibody profile
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What is the major antibody in Graves disease?
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TSHRab
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___ can be characterized as a chronic, symmetric and erosive arthrisis of the peripheral joints and can also affect organs.
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Rheumatoid arthritis - RA
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Two types of tests used to test RF in RA are
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one using sheeps blood cells coated with igG, and one with latex particles
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Diabetes Mellitus is Type __
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Type 1A
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___ is an autoimmune disease that affects the nueromuscular junction and characterized by weakness and fatigability of skeletel muscles. Causes droops in eyelids and retracts corners of mouth
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Myasthenia Gravis (MG)
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___ are gram-positive spherical, ovoid, or lancet shaped organism that are catalase negative and are often seen in pairs or chains.
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Streptococci
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___ which belons to lancefild group A, is the most common ubiquitous pathogenic bacteria and cause a variety of infections.
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Stretococcus pyogenes
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The ___ protien is the major virulence factor of the Lancefeild group A.
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M Protein
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___ involves identification of M-protien antigens by precipitation with type-specific antisera
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Serotyping
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___ involves PCR amplification of a portion of the emm gene which codes for M-protein.
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Genotyping
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The ___ test is a flide agglutination screening test for the detection of antibodies to several streptococcal antigens
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Streptozyme
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___ is a gram negative, microaerophilic spiral bacterium and major cause of both gastric and duodenal ulcers
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Helicobacter Pylori
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The severity of heliocobacter pylori is related to the injection of the __ protien into the gastric epithelial cells.
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Cag A
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H. pylori produces a large amount of ___,, so a biopsy urase test may be done to detect the presence of bacteria.
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Urease
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The breath technique for h. pylori uses radioactivity; therefore serological testing is the primary screening method. The test methodology of choice is the ___.
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ELISA
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