Serology And Bb Exam 1

Front 1

the state of protection from infectious disease

Back 1

Immunity

Front 2

What are the two divisions of innate immunty and adaptive immunity

Back 2

cellular and humoral

Front 3

-non specific or natural immunity
-1st line of defense
-non-specific/ non adaptive to pathogen exposure
-External and internal defense systems
-Immeadiately available

Back 3

Innate immunity

Front 4

cellular involvement of innate immunity incolves? (4)

Back 4

nuetros, eos, baso, monos. NOT lymphs

Front 5

humoral involvement of innate immunity

Back 5

complement (alternate) pathway

Front 6

-specific or acquired immunity
-high degree of specificity
-adaptive immune response (immunologic memory)
-memory response with 2nd response being quicker and stronger
-self/ non-self recognition

Back 6

Adaptive immunity

Front 7

cellular involvement of adaptive immunity

Back 7

-lymphocytes (T memory cells)
-B cells (B- memory and plasma cells)

Front 8

humoral involvement of adaptive immunity

Back 8

- antibodies
- complement (classic) pathway

Front 9

Interactive network 1st and 2nd line of defense is which type of immunity?

Back 9

innate immunity

Front 10

3rd line of defense is which type of immunity?

Back 10

adaptive immunity

Front 11

Two types of immunity

Back 11

Innate and adaptive

Front 12

1st line of defense of defense includes what two components

Back 12

physical & biochemical component

Front 13

physical components of innate immunity include...

Back 13

intact skin, mucous membrances, cilia, cough/reflect sneeze

Front 14

biochemical components of innate immunity include...

Back 14

secretions: sweat, saliva, tears

Front 15

Innate immunity mechanisms of external defense. (1st line)

Back 15

physical components and biochemichal components

Front 16

Innate immunity mechanisms of internal defense. (2nd line)

Back 16

cellular components and humoral/biochemical components

Front 17

cellular components of innate immunity include? (7)

Back 17

nuetro, monos, tissue macrophages, dendritic cells, eos, basos, NK cells

Front 18

Humoral/biochemical components of innate INTERNAL defense includes?

Back 18

-complement (alternate) pathway
-cytokines
-acute inflammatory reactions

Front 19

signal more potent cells to site of injury or inflammationa and includes interluekins (IL) and interferons (INF)

Back 19

cytokines

Front 20

name the 5 steps of phagocytosis in innate immunty internal defense

Back 20

1. attachment of bacterium
2. ingestion
3. fusion and release of lysosomal enzymes
4. digestion
5. release of digested products

Front 21

in phagocytosis, when the some and the cell are in ingestion what are they now called?

Back 21

phagolysosome

Front 22

-predominant cell in circulation
-usually 1st phagocytic WBC at site of injury/ infection
- stimulated by presence of ab or inactivated complement components

Back 22

Neutrophils

Front 23

-can also be found in tissues as macrophages
-have digestive vacuoles
-fine granules w/ peroxidase, acid phosphotase, B- glucoronidase, lysozymes, and lipase
-predominant cell at inflimmation site in LATE stage of reaction

Back 23

monocytes

Front 24

-increased endoplasmic reticulum lysosomes
- longer life span
- tissue locations(aveolar, kuppfer cells, microglial, histocytes)

Back 24

Tissue macrophages (monocytes)

Front 25

-most potent
-highest endocytic activity

Back 25

dendritic cells

Front 26

-large granular lymphocytes
-*plays role in EARLY stages of viral infection and tumorgenisis
-INL-2--> anti cancer agent that helps to break down tumors

Back 26

NK cells

Front 27

-hypersensitivity rxn's
-have surface membrane receptor sites for Fc portion of IgE immunoglobulins
-granules: histamine chemoactiv factor, small amount of heparin

Back 27

Basophils

Front 28

-increased in severe allergic rxn's (like hay fever)
-increased in parasitic infections
-nuetralized basophil products

Back 28

eosinophils

Front 29

-APRs
- Increased synthesis after tissue injury, increased concentration at site of injury and in plasma, increased in wound healing

Back 29

innate immunity- soluble factors

Front 30

-C reactive protein
- complement
-haptoglobin
-fibrinogen (APR)
- a-1 antitrypsin
-ceruloplasmin
- serum amyloid A

Back 30

innate immunity soluble factors

Front 31

-binds to C-polysaccharide wall, found on bacteria and fungi
-increased w/in 4-6 hrs of injury, peaks at 24 hrs.
-widely used as indicator of acute inflammation( you wont see it in any chronic condition)
-activator of complement pathway

Back 31

C- reactive protein

Front 32

- risk factor for MI
-gives false negative in latex agg. test
-must used 1/5 dilution in latex agg. test

Back 32

C- reactive protein

Front 33

-group of serum proteins
-circulates inactive, turned on by specific or non- specific immunologic mechanisms
- has three different biochemical pathways

Back 33

Complement

Front 34

name the three different biochemical pathways of complement soluble factor

Back 34

1- classical (adaptive)
2. alternate (innate)
3. lectin pathway

* all lead to same result*

Front 35

adds something to bacteria that makes it more appealing to the phagocyte for phagocytosis to occur

Back 35

opsonization

Front 36

-binds irreversibly to free hgb
-increased 2-4x after injury
-will at first show a decrease, but later show an increase

Back 36

Haptoglobin

Front 37

-APR
-increases tensile strength of wound( holds it together like a web)

Back 37

Fibrinogen

Front 38

-helps clean up enzyme activity
-general plasma inhibitor of protease
-counteracts degrading enzyme activity

Back 38

a-1 antitrypsin (AAT)

Front 39

-copper transfer
-cytochrome C oxidase (phagocytosis)

Back 39

ceruloplasmin

Front 40

-traffic controller and chemical signaling
-promotes adhesion and chemotaxis of phagocytic cells and lymphocytes

Back 40

serum amyloid A