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14 Cards in this Set
- Front
- Back
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5 main events that occur in asthma
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triggering
signaling migration cell activation tissue stimulation and damage |
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triggering
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antigen binds to immunoglobulin E(IgE) w/c is attached to activated mast cells
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nonallergic factors
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aspirin
viral infxn |
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early asthmatic response
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30min of trigger exposure
blked by b agonist cromolyn na nedocromil |
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late asthmatic attack
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2nd decline in lung fxn
4-8 hrs after initial trigger persistent airflow obstruction and bronchial hyperresponsiveness response is blked by adm of corticosteroids cromolyn na nedocromil |
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signaling
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release chemical signals which attract addl inflam cells to the airways
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signaling cells
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lymphocytes
eosinophils epithelial cells macrophages |
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chemical signals
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cytokines
chemokines eicosanoids leukotrienes |
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migration
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influx of inflam cells begins to airway, upregulation of adhesion molecules begin
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adhesion molecule
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affix themselves to cells in the circulation and attract these cells to the airways
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cell activation
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required before cells can release inflam mediators
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leukotriene
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impt in cell activation
devpmt of bronchoconstriction, inc mucus prodxn, inc vascular permeability hyperresponsiveness |
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addl inflam mediators
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eosinophil chemotactic factor
neutrophil chemotactic factor basophil chemotactic factor platelet activated factor |
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tissue stimulation and damage
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occurs as a result of these inflam mediators released from activated cells
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