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14 Cards in this Set

  • Front
  • Back
5 main events that occur in asthma
triggering
signaling
migration
cell activation
tissue stimulation and damage
triggering
antigen binds to immunoglobulin E(IgE) w/c is attached to activated mast cells
nonallergic factors
aspirin
viral infxn
early asthmatic response
30min of trigger exposure

blked by b agonist
cromolyn na
nedocromil
late asthmatic attack
2nd decline in lung fxn
4-8 hrs after initial trigger
persistent airflow obstruction and bronchial hyperresponsiveness
response is blked by adm of corticosteroids
cromolyn na
nedocromil
signaling
release chemical signals which attract addl inflam cells to the airways
signaling cells
lymphocytes
eosinophils
epithelial cells
macrophages
chemical signals
cytokines
chemokines
eicosanoids leukotrienes
migration
influx of inflam cells begins to airway, upregulation of adhesion molecules begin
adhesion molecule
affix themselves to cells in the circulation and attract these cells to the airways
cell activation
required before cells can release inflam mediators
leukotriene
impt in cell activation
devpmt of bronchoconstriction, inc mucus prodxn, inc vascular permeability
hyperresponsiveness
addl inflam mediators
eosinophil chemotactic factor
neutrophil chemotactic factor
basophil chemotactic factor
platelet activated factor
tissue stimulation and damage
occurs as a result of these inflam mediators released from activated cells