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35 Cards in this Set

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  • Back
____ acts as a bridge between a specific glycoprotein on the surface of platelets (GPIb/IX) and collagen fibrils.
vWF
vWF binds to and stabilizes coagulation factor ____, and is required for normal survival of the factor in circulation.
VIII
The initial activation of platelets is induced by ____ binding to specific receptors on the surface of platelets, thereby initiating a signal transduction cascade.
thrombin
The factors involved in the intrinsic pathway are ____,____,____,____, and ___.
VIII, XII, XII, IX, X
The intrinsic pathway requires the proteins ____ and ____ secreted by the platelets along with Ca ions and phospholipids.
prekalikrein, HK
Initiation of the intrinsic pathway occurs when prekallikrein, high-molecular-weight kininogen, factor XI and factor XII are exposed to a _____ charged surface, and is termed the ____ phase.
negatively, contact
Conversion of prekallikrein to kallikrein, activates factor ____ to factor ___a.
XII
Factor XIIa activates _____ to _____ and factor ___ to factor ____a and leads to the release of bradykinin from high-molecular-weight kininogen.
prekalkrien, kalikrein, XI, XI
In the presence of Ca2+, factor XIa activates factor ___ to factor ____a.
IX, IX
Factors __, ___, ____, ____ contain vitamin K-dependent g-carboxyglutamate.
prothrombin (II), VII, IX, and X
The activation of factor ____ requires assemblage of the tenase complex on the surface of activated platelets.
Xa
The tenase complex consists of ___ and factors ___, ____, ____.
Ca2+, factors VIIIa, IXa and X
The role of factor ____ is to act as a receptor in the tenase complex.
VIII
The conversion of factor XIII to factor IIIa is activated by _____.
thrombin
In response to increased thrombin, factor VIIIa is cleaved by _____.
thrombin
Activated factor ____ is where the extrinsic and intrinsic pathways converge.
Xa
The extrinsic pathway is inititiated in the response to ____ factor.
tissue
The activation of factor VII occurs through the action of factor ____ or ___.
Xa, thrombin
____ is a cofactor in the catalyzation of factor X by factor VIIa.
TF
Factor ____, a gla residue containing serine protease, cleaves factor X in a manner identical to that of factor ___ of the intrinsic pathway.
VIIa, IXa
Factor ___ of the intrinsic pathway can also be activated by factor VIIa and TF.
IX
persons with hereditary deficiencies in the components of the ____ phase of the intrinsic pathway do not exhibit clotting problems.
contact
Persons with hereditary deficiencies in the components of the contact phase of the intrinsic pathway do not exhibit clotting problems because of _____.
factor VIIa and TF being able to activate factor IX
____ is a major extrinsic pathway inhibitor of the VIIa-TF complex.
LACI
LACI only binds to factor VIIa in the presence of factor ____.
Xa
The prothrombinase complex is formed from factors ____, ____, prothrombin and the platelet phospholipids and Ca ions.
Xa, Va
Thrombin combines with _____ present on endothelial cell surfaces forming a complex that converts protein C to protein Ca, which with cofactor protein S degrade factors ___ and ___.
thrombomodulin, Va, VIIIa
____ is the most important thrombin inhibitor and also inactivates factors IXa, Xa, XIa and XIIa.
antithrombrin III, IXa,Xa,XIa,XIIa
a2-macroglobulin, heparin cofactor II and a1-antitrypsin are inhibiitors of _____.
thrombin
Active thrombin is a serine protease that _____ fibrinogen at four arg-gly bonds between the fibrinopeptide and the a and b portions of the protein.
hydrolyses
thrombin converts activates factor ___, a highly specific transglutaminase that introduces cross-links composed of covalent bonds between the amide nitrogen of ____ and e-amino group of _____ in the fibrin monomers.
XIII, glutamines, lysines
Any free circulating plasmin is rapidly inhibited by _____.
a2-antiplasmin
Plasminogen is activated by ____, ___ and ____.
tPA, urokinase, streptokinase
Hemophilia A is an X linked disorder associated with factor ___.
VIII
Hemophilia B is associated with defective factor ___.
IX