Seizure Meds

Front 1

Partial seizure DOC (drug of choice)

Back 1

Carbamazepine, also phenytoin & phenobarbital

Front 2

Absence seizure/petit mal DOC

Back 2

ethosuximide (Zarontin), also clonazepam

Front 3

Grand mal seizure/tonic-clonic DOC

Back 3

Carbamazepina (tegretol) phenytoin, phenobarbital, also valproic acid, topiramate (topamax), adjunt Lamotrigine (lamictal). Extreme cases Felbamate

Front 4

Atonic seizure DOC

Back 4

Valproic Acid, also Clonazepam, Lamotrigine (adjunt)

Front 5

Lenox-gastuat syndrome DOC

Back 5

Valproic Acid, Clonazepam

Front 6

Lenooux-gastuat syndrome > 30 minutes TTO

Back 6

inminent CNS damage. 100 mg thiamine complex, 25 g glucosa (50 ml 50%) Diazepam IV 10-20 mg 2-5 min, Phenytoin 18 mg/kg to reach therapeutic levels, but less than 50 mg/min or cadiac risk (propylen glycol)

Front 7

Seizures drugs discontinuation

Back 7

Slow over 6 weeks to 3 month, or risk of status epilepticus

Front 8

Drugs that may cause seizures

Back 8

wellbutrim (bupropion)alcohol, cocaine, theophylline in high doses, lidocaine, meperidine(demerol), diazepam, tramadol, meropenem carbopenem, meropenem, ganziclovir, penicillin, ROH and barbituric withdrawal

Front 9

Phenytoin (Dilantin)IM?

Back 9

No, slow, erratic absortion, painful local reaction. Use cerebyx instead IM, IV.

Front 10

Cerebryx drug, via of administration, storage and type of drug

Back 10

Fosphenytoin, IV, IM, REFRIGERATE and prodrug

Front 11

Patient counceling with phenytoin and fosphenytoin

Back 11

Take it with food or milk to avoid GI symptoms, good dental care (gingival hyperplasia), do not take a discolored capsule

Front 12

DOC to prevent seizure

Back 12

Phenytoin

Front 13

Phenytoin dose, loading dose, therapeutic range, IV caution. Pharmacology

Back 13

4-6 mg/kg/day TID or Kapseals QD, 18 mk/kg, 10 - 20 mg/liter. no more that 50mg/min, only with normal saline use filter. Dose dependent First order kinetic first order to 0 order (dose dependent)

Front 14

Funnytoin Adverse effects

Back 14

gingival hyperplasia, NAGS (nistagmis, ataxia, GI, sedation, osteomalacia(vitamin D deficiency)

Front 15

Phenytoin drug interaction

Back 15

Fluconazole, omeprazole, cimetidine increase phenytoin toxicity. Disulfiram increase phenytoin effect. Phenytoin decrese contraceptive and corticosteroid (dexamethasone)effects

Front 16

Valproic Acid drug, brand name, indication

Back 16

depakene, tto absence and complex partial seizure

Front 17

Divalproex sodium brand name, indication

Back 17

Depakote EC (enteric coat), FDA approved for Mania (bipolar, and Migrain)

Front 18

Valproic Acid, Divalproex sodium side effects

Back 18

Hepatotoxicity, pancreatis,bone marrow problems(trombocitopenia, anemia, neutropenia) hair loss, weight gain

Front 19

Seizure drugs with possible hepatic complication

Back 19

valproic acid, carbamazepina, phenytoin

Front 20

Seizure drugs with possible renal complication

Back 20

Neurontin (gabapentin), Topamax (topiramate) Keppra (levetiracetam)

Front 21

drugs that will decrece valproic acid (substrate) levels

Back 21

carbamazepine, phenobarbital, phenytoin

Front 22

Depakote EC drug interactions

Back 22

Antiacids will increase stomach pH and will disolve the enteric coat faster

Front 23

Valproic acid: substrate or inducer?

Back 23

Substrate

Front 24

Carbamazepine brand name, dose & pharmacology

Back 24

Tegretol, 100 -200 mg QPm blood levels fall in 2-4 weeks (autoinducer)

Front 25

Carbamazepine adverse effects

Back 25

AAAA: aplastic anemia, agranulocitosis, antiarrithmic, anticholinergic. NAGS:Nistagmis, ataxia, GI, sedation.

Front 26

Carbamazepine drug interaction

Back 26

Drugs that will increase CBZ(carbamazepine):erythromycin, clarithromycin, ketoconazole, itraconazole, diltiazem, verapamil, norvir (ritonavir). Reduce effects of contraceptives

Front 27

Seizure medication that may cause kidney stones

Back 27

Zonisamide (Zonegran) and Topiramate (Topamax)

Front 28

Seizure medication that may cause weight loss

Back 28

Topiramate (topamax)

Front 29

Seizure medication that may cause weight gain

Back 29

All but topiramate (topamax)

Front 30

Seizure medication that goes thru the liver

Back 30

All but gabapentin and levetiracetam (keppra)

Front 31

Seizure medication that goes thru kidneys

Back 31

Levetirocetam (keppra) and Gabapentin (neurotin). Renal Failure

Front 32

Felbamate indications

Back 32

ONLY ON PATIENT WITH NO RESPONSE TO OTHER THERAPIES. LIVER

Front 33

Felbamate Side effects

Back 33

Aplasic anemia and Hepatoxicity, liver failure

Front 34

Gabapentin loading dose and dose. Indication

Back 34

start with 100 mg TID increase until effects reached. 900 - 4800 mg daily. Partial seizures adjunt. RENAL

Front 35

Lamotrigine brand name and side effects

Back 35

Lamictal, rash and photosensitivity

Front 36

Lamotrigine and valproic acid

Back 36

Valproic acid is an inducer of lamotrigine, so we have to lower the dose to a 100 -200 mg qh when administer with valproic acid. LIVER

Front 37

Levetiracetam brand name, side effects

Back 37

Keppra, somnolence and psychiatric symptoms

Front 38

topiramate brand name, side effects, counceling

Back 38

Topamax, Nephrolithiasis (kidney stones), weight loss (anorexia). don't brake pill (bitter taste) drink lots of water (kidney stones)

Front 39

Carbamazepine & tricyclics antidepressants

Back 39

They are related in terms of structure, so patients allergics to tricyclics antidepressants may be allergic to carbamazepine

Front 40

If a pregnant woman in epileptic and is taking valproic , what should she use to avoid congenital malformations on her baby

Back 40

Folic acid, because anticonvulsivants normally reduces folic acid, and this is a major cause of spina bifida

Front 41

Topiramate & weight

Back 41

Topamax (topiramate) can cause significant weight loss (anorexia)

Front 42

Valproic acid & weight

Back 42

Depakene can cause significant weight gain

Front 43

Rash and Seizure medications

Back 43

All of the anticonvulsivants are assoicated with life threatening rash.

Front 44

Carbamazepine drug interactions

Back 44

Because it is an inducer it has a lot of drug-drug interactions

Front 45

Anti-seizure medications with black box warning

Back 45

carbamazepine and felbamate (aplastic anemia and hepatic failure)

Front 46

absence seizure medication for a 1 year old baby

Back 46

Ethosuximide (zarontin)

Front 47

Complex febrile seizures duration and complications

Back 47

Last for >15 min recurrent in 24 hours and do not have any consecuenses like epilepsy

Front 48

Meperidine & renal failure

Back 48

Meperidine accumulates in patients with renal failure and causes seizures

Front 49

Wich drug has Michaelis-Menten parmacokinetics

Back 49

Phenytoin, because of its dose, goes from first order kinetis to 0 order kinetics

Front 50

Drugs that decreaces phenytoin

Back 50

Antiacids, cisplatin, ritonavir(norvir), zodovudine, kava kava and valerian

Front 51

Drugs that increases phenytoin

Back 51

alcohol abuses, diaepam, estrogens, salicilates, sulfas, warfarin.

Front 52

Phenytoin and weight

Back 52

Phenytoin do not have a effect on patients weight

Front 53

Primidone is a metabolite of...?

Back 53

Phenobarbital