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16 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Mechanism of action of Benzodiazepines
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Bind to GABA-A receptors(a&g subunit)--> increase affinity of rec. for GABA.
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Physiologic effect of benzos
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-increased Cl- into postsynaptic neuron which decreases action potentials
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Potentiates GABAergic neurotransmission at all levels of CNS
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Benzo receptor involved in sedation and hypnosis
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BZ 1 receptor--> alpha1-GABA-A receptors
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Benzo receptor involved in cognition and motor function
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BZ 2 receptor--> alpha2-GABA-A receptors
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Anxiolytic action of Benzos
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-w/in the Limbic System
-BZ 2 receptors mainly |
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Hypnotic action of Benzos
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-BZ 1 receptors mainly
-Decrease: -time to onset of sleep -stage 3&4 of sleep cycle -Prolong stage 1&2 |
Caution in pts. w/ COPD or obstructive sleep apnea
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What benzo is used as a spasmolytic?
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Diazepam (Valium)
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GABAa Receptor sensitizer
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What benzo is used as an anti-convulsant?
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Diazepam (Valium) IV
Lorazepam (Ativan) IM |
Immediate administration for status epilepticus.
-Lorazepam is the better benzo for this. |
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Most commonly used long-acting benzo?
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Diazepam
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Most commonly used medium-acting benzo?
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Lorazepam (Ativan)
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Most commonly used short-acting benzo?
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Alprazolam (Xanax)
Midazolam (Versed) |
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Most effective benzo for treatment of panic disorder with agoraphobia?
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Alprazolam
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Ideal benzo for conscious sedation and outpatient procedures?
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Midazolam (Versed)
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3-4x more potent than diazepam
-short-acting |
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Benzodiazepine antagonist?
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Flumazenil (Mazicon)
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-for use to reduce sedative effects after anesthesia or for an overdose.
-caution in pts with long-term benzo use-> can induce seizures |
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Non-benzo benzodiazepines?
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-Zolpidem (Ambien)
-Eszopiclone (Lunesta) |
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Treatment of insomnia?
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-Zolpidem (Ambien)
-Eszopiclone (Lunesta) |
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