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15 Cards in this Set
- Front
- Back
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Sedatives
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Reduce activity with little effect on motor or mental functions
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Hypnotics
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Used to facilitate the onset and maintenance of sleep
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CNS Depressants Action
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Stimulation of GABA A receptor results in influx of chloride which hyperpolarizes the cell.
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Benzodiazepine effect on ion channel
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Increase the frequency of channel opening even in the absence of GABA - can induce fatal effects
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Barbiturates effect on ion channel
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Increases the duration of channel opening
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Benzodiazepine Clinical Usage
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Seizures
Physiological Dependence to other sedatives Situational Anxiety Anxiety Disorders Insomnia |
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Barbiturates Clinical Usage
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Seizures
Intravenous Anesthetics Euthanasia CAN PRODUCE FATAL EFFECTS!! |
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Adverse Effects of Sedatives
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Withdrawl
Tolerance (esp. benzos) Side Effects: Respiratory Depression, Increased HR, Overdose, Abuse Potential |
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Alcoholics and Benzos
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Increased potential for abuse if already abusing a sedative (ie. Alcohol)
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Drug Interactions
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Any CNS Depressants
-Exhibit additive/synergistic effect with benzo/barb |
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Busiprone(Buspar)
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Relieves anxiety w/out causing sedation or euphoria
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Phenobarbital
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Long lasting barbiturate (anti-seizure)
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Methohexital
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Ultra short-acting barbiturate (anesthesia)
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Triazolam
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Short acting benzodiazepine (insomnia)
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Diazepam
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long acting benzodiazepine (anxiety, alcohol detox)
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