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32 Cards in this Set

  • Front
  • Back
lifetime prevelance of schizophrenia
1%
positive symptoms
-delusions (FIXED, false beliefs)
-hallucinations (auditory hallmark)
negative symptoms
-blunted effect
-anhedonia
-avolition
-poverty of speech
-poor hygiene
nigrostriatal dopaminergic tract function (2)
1)EPS
2)movement
mesolimbic function (4)
1)arousal
2)memory
3)stimulus processing
4)motivational behavior
mesocortical function (4)
1)cognition
2)communication
3)social function
4)stress response
tuberoinfundibular function (1)
1)regulates PL release
neurochemical alterations in the limbic system and mesocortical tract
mesolimbic system has increased DA, mesocortical tract has decreased DA
positive symptoms are thought to come from which dopaminergic tract?
2-mesolimbic
negative symptoms are thought to come from which dopaminergic tract?
3-mesocortical
dystonia definition
sustained muscle contraction
onset of dystonia
1-4d after dose administration or dose increase
dystonia risk factors
young males, high potency APs
akathisia definition
subjective feeling of motor restlessness
akathisia objective signs
-pacing
-tapping feet
-inability to sit still
akathisia onset
days to weeks
akathisia occurence
20-40% of pts treated w/ high potency agents
list the four cardinal symptoms of pseudoparkinsonism
1)akinesia, bradykinesia, bradyphrenia
2)resting tremor
3)cogwheel rigidity
4)postural abnormalities
pseudoparkinsonism onset
1-2wks after initiation of therapy or dose increase
pseudoparkinsonism risk factors
-female
-age >40
-high potency APs
tardive dyskinesia definition
abnormal involuntary movements
(chewing/lip smacking, foot tapping, toe movement, tics, grimaces, blinking, tongue thrusting)
movements tend to increase when a patient is _____ and disappear during _____
aroused; sleep
tardive dyskinesia onset
insidious, occurs w/ chronic treatment
tardive dyskniesia risk factors
-increasing age
-acute EPS
-poor AP response
-organic mental d/o
-diabetes
-mood d/o
-females
key to tardive dyskinesia
prevention since it is often irreversible
neuroleptic malignant syndrome characterization
-hyperpyrexia
-altered MS
-tachycardia
-fluctuating BP
-sweating
-urinary, fecal incontinence
-rigidity
abnormal labs that are common with neuroleptic malignant syndrome
elevated CPK, LFTs
risk factors for neuroleptic malignant syndrome
pts receiving high potency, injectible, or depot APs
neuroleptic malignant syndrome onset
ranges from initial treatment to several months after initial treatment
effect of APs on ECG
-APs can produce direct myocardial depression, and can antagonize sympathetic nervous system activity
-ECG changes include tachycardia, flattened T waves, ST segment depression, and prolongation of QT and PR intervals
normal prolactin concentration
1.4ng/mL-26.7ng/mL
elevated PL levels may lead to what? (5)
1)amenorrhea
2)galactorrhea
3)gynecomastia
4)sexual dysfunction
5)osteoporosis