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8 Cards in this Set
- Front
- Back
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SE's are nephrotoxicity and acoustic nerve damage:
Major SE is cardiotoxicity: Pulmonary fibrosis: Hemorrhagic cystitis: |
Cisplatin
anthracyclines (doxorubicin) bleomycin cyclophosphamide/ifosfamide |
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Three types of vomiting associated with chemo:
Two drugs with high risk of emesis: Two drugs with high risk of cerebellar toxicity: |
Acute (within 1-2 hrs), Delayed (>24h), Anticipatory (prior to tx, conditioned response)
Cisplatin, cyclophosphamide cytarabine, high dose MTX |
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Vinca alkaloids generally have what effect on nervous sytem?
Most neurotoxic vinca alkaloid: Drug that has ocular toxicity: Ototoxicity: Major toxicity of anthracyclines: |
Peripheral neuropathy
Vincristine cytarabine cisplatin cardiotoxicity |
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What drug protects against cardiotoxicity from anthracyclines?
Pulmonary toxicity, interstitial pneumonitis, pulmonary fibrosis: High renal toxicity, renal tubular damage: How to prevent renal toxicity? |
Dexrazoxane
bleomycin Cisplatin N/S hydration, mannitol, furosemide if UO < 100 ml/hr |
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High risk for bladder toxicity:
Prophylaxis for hemorrhagic cystitis: Drug with high hepatic toxicity, Hepatic Veno-Occlusive disease: Drugs associated with acute Type I hypersensitivity reactions: |
cyclophosphamide, ifosfamide
hydration, Mesna, bladder irrigation Busulfan taxanes - paclitaxel, docetaxel |
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Monoclonal Ab drugs have what ending?
Which Mab is an Ab against the Her-2 protein, used in breast cancer? -nib drugs are what type? Mab against VEGF? |
-mab
Trastuzumab small molecule tyrosine kinase inhibitors Bevacizumab |
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Types of cancers with increased EGFR:
NSCLC is targeted by which drugs? Colon Ca is targeted by which drugs? Promotes activity of B-cells, T-cells, macrophages, dendritic cells, increases Fc receptor expression: |
solid tumors - colorectal, lung carcinoma, head/neck cancers
-nibs -mabs IFN-A |
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Two multi-target small molecule inhibitors:
Bevacizumab is approved for what cancers? Rituximab has been shown to be effective against what cancer? Targets CD33: Indicated for RCC, malignant melanoma: |
Sorafenib, Lapatinib
NSCLC, colon ca B-cell lymphomas Gemtuzumab IL-2 |
